Search Results - "Sancineto, Luca"

Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation by Santi, Claudio, Scimmi, Cecilia, Sancineto, Luca

“…Ebselen is the leader of selenorganic compounds, and starting from its identification as mimetic of the key antioxidant enzyme glutathione peroxidase, several…”
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New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use by Benedetto Tiz, Davide, Bagnoli, Luana, Rosati, Ornelio, Marini, Francesca, Sancineto, Luca, Santi, Claudio

“…This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at least one halogen atom (covalently bound)…”
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Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds by Santi, Micol, Sancineto, Luca, Nascimento, Vanessa, Braun Azeredo, Juliano, Orozco, Erika V M, Andrade, Leandro H, Gröger, Harald, Santi, Claudio

“…Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts in both industry and academia. In the last two decades, the…”
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New Insights into Green Protocols for Oxidative Depolymerization of Lignin and Lignin Model Compounds by Scimmi, Cecilia, Sancineto, Luca, Drabowicz, Jozef, Santi, Claudio

“…Oxidative depolymerization of lignin is a hot topic in the field of biomass valorization. The most recent and green procedures have been herein detailed…”
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Continuous Bioinspired Oxidation of Sulfides by Mangiavacchi, Francesca, Crociani, Letizia, Sancineto, Luca, Marini, Francesca, Santi, Claudio

“…A simple, efficient, and selective oxidation under flow conditions of sulfides into their corresponding sulfoxides and sulfones is reported herein, using as a…”
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"Green Is the Color": An Update on Ecofriendly Aspects of Organoselenium Chemistry by Azeredo, Juliano B, Penteado, Filipe, Nascimento, Vanessa, Sancineto, Luca, Braga, Antonio L, Lenardao, Eder João, Santi, Claudio

“…Organoselenium compounds have been successfully applied in biological, medicinal and material sciences, as well as a powerful tool for modern organic…”
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Synthesis of Spirooxindole Oxetanes Through a Domino Reaction of 3‐Hydroxyoxindoles and Phenyl Vinyl Selenone by Palomba, Martina, Scarcella, Elisabetta, Sancineto, Luca, Bagnoli, Luana, Santi, Claudio, Marini, Francesca

“…An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl selenone with 3‐hydroxyoxindoles under aqueous basic conditions at room…”
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Selenium Catalyzed Oxidation of Aldehydes: Green Synthesis of Carboxylic Acids and Esters by Sancineto, Luca, Tidei, Caterina, Bagnoli, Luana, Marini, Francesca, Lenardão, Eder J, Santi, Claudio

“…The stoichiometric use of hydrogen peroxide in the presence of a selenium-containing catalyst in water is here reported as a new ecofriendly protocol for the…”
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FDA-Approved Small Molecules in 2022: Clinical Uses and Their Synthesis by Benedetto Tiz, Davide, Bagnoli, Luana, Rosati, Ornelio, Marini, Francesca, Santi, Claudio, Sancineto, Luca

“…This review describes the recently FDA-approved drugs (in the year 2022). Many of these products contain active moieties that FDA had not previously approved,…”
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Organic Diselenides: Versatile Reagents, Precursors, and Intriguing Biologically Active Compounds by Claudio Santi, Cristina Tomassini, Luca Sancineto

“…In this account, we describe how some organic diselenides were successfully used in the past as reagents for asymmetric stereoselective synthesis and more…”
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Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors by Krasowska, Dorota, Iraci, Nunzio, Santi, Claudio, Drabowicz, Józef, Cieslak, Marcin, Kaźmierczak-Barańska, Julia, Palomba, Martina, Królewska-Golińska, Karolina, Magiera, Jakub, Sancineto, Luca

“…A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the…”
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Top Selling (2026) Small Molecule Orphan Drugs: A Journey into Their Chemistry by Benedetto Tiz, Davide, Bagnoli, Luana, Rosati, Ornelio, Marini, Francesca, Sancineto, Luca, Santi, Claudio

“…This review describes, from a chemical point of view, the top "blockbuster" small molecule orphan drugs according to their forecasted sales in 2026. Orphan…”
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Simple Zn-Mediated Seleno- and Thio-Functionalization of Steroids at C-1 Position by Grześ, Paweł A, Monti, Bonifacio, Wawrusiewicz-Kurylonek, Natalia, Bagnoli, Luana, Sancineto, Luca, Jastrzebska, Izabella, Santi, Claudio

“…Here we report the reaction in the biphasic system of the in situ prepared selenols and thiols with 1,4-androstadiene-3,17-dione ( ) or prednisone acetate ( )…”
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Chalcogenium-AZT Derivatives: A Plausible Strategy To Tackle The RT-Inhibitors-Related Oxidative Stress While Maintaining Their Anti- HIV Properties by Sarturi, Joelma M, Dornelles, Luciano, Segatto, Natalia V, Collares, Tiago, Seixas, Fabiana K, Piccoli, Bruna Candia, da Silva, Fernanda D'Avila, Omage, Folorunsho Bright, da Rocha, João Batista Teixeira, Balaguez, Renata A, Alves, Diego, Lenardão, Eder J, Lopes, Eric F, Kula-Pacurar, Anna, Pyrc, Krzysztof, Sancineto, Luca, Rodrigues, Oscar E D

“…This study presents the synthesis and multi-target behavior of the new 5'-hydroxy-3-(chalcogenyl-triazoyl)-thymidine and the biological evaluation of these…”
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New insights in the mechanism of the SARS-CoV-2 Mpro inhibition by benzisoselenazolones and diselenides by Sancineto, Luca, Mangiavacchi, Francesca, Dabrowska, Agnieszka, Pacuła-Miszewska, Agata J., Obieziurska-Fabisiak, Magdalena, Scimmi, Cecilia, Ceccucci, Veronica, Kong, Juan, Zhao, Yao, Ciancaleoni, Gianluca, Nascimento, Vanessa, Rizzuti, Bruno, Bortoli, Marco, Orian, Laura, Kula-Pacurar, Anna, Yang, Haitao, Ścianowski, Jacek, Lei, Ying, Pyrc, Krzysztof, Santi, Claudio

“…Although global vaccination campaigns alleviated the SARS-CoV-2 pandemic in terms of morbidity and mortality, the ability of the virus to originate mutants may…”
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Synthesis and biological evaluation of new nitrogen-containing diselenides by Nascimento, Vanessa, Ferreira, Natasha L., Canto, Rômulo F.S., Schott, Karen L., Waczuk, Emily P., Sancineto, Luca, Santi, Claudio, Rocha, João B.T., Braga, Antonio L.

“…The antioxidant properties of organoselenium compounds have been extensively investigated with the aim of developing new drugs, since oxidative stress is…”
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Water and Aqueous Mixtures as Convenient Alternative Media for Organoselenium Chemistry by Santi, Claudio, Jacob, Raquel G, Monti, Bonifacio, Bagnoli, Luana, Sancineto, Luca, Lenardão, Eder J

“…Even if water is the natural environment for bioorganic reactions, its use in organic chemistry is often severely limited by the high insolubility of the…”
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Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives by Mangiavacchi, Francesca, Coelho Dias, Italo Franco, Di Lorenzo, Irene, Grzes, Pawel, Palomba, Martina, Rosati, Ornelio, Bagnoli, Luana, Marini, Francesca, Santi, Claudio, Lenardao, Eder Joao, Sancineto, Luca

“…In the last decades, organoselenium compounds gained interest due to their important biological features. However, the lack of solubility, which characterizes…”
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l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells by Sancineto, Luca, Ostacolo, Carmine, Ortega-Alarcon, David, Jimenez-Alesanco, Ana, Ceballos-Laita, Laura, Vega, Sonia, Abian, Olga, Velazquez-Campoy, Adrian, Moretti, Silvia, Dabrowska, Agnieszka, Botwina, Pawel, Synowiec, Aleksandra, Kula-Pacurar, Anna, Pyrc, Krzysztof, Iraci, Nunzio, Santi, Claudio

“…The COVID-19 pandemic outbreak prompts an urgent need for efficient therapeutics, and repurposing of known drugs has been extensively used in an attempt to get…”
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Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly by Massari, Serena, Nannetti, Giulio, Goracci, Laura, Sancineto, Luca, Muratore, Giulia, Sabatini, Stefano, Manfroni, Giuseppe, Mercorelli, Beatrice, Cecchetti, Violetta, Facchini, Marzia, Palù, Giorgio, Cruciani, Gabriele, Loregian, Arianna, Tabarrini, Oriana

“…The limited number of drug classes licensed for treatment of influenza virus (Flu), together with the continuous emergence of viral variants and drug resistant…”
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