Search Results - "Sanchez, Washington"

Support for the Safe Use of Zinc Oxide Nanoparticle Sunscreens: Lack of Skin Penetration or Cellular Toxicity after Repeated Application in Volunteers by Mohammed, Yousuf H., Holmes, Amy, Haridass, Isha N., Sanchez, Washington Y., Studier, Hauke, Grice, Jeffrey E., Benson, Heather A.E., Roberts, Michael S.

“…Zinc oxide is a widely used broad-spectrum sunscreen, but concerns have been raised about the safety of its nanoparticle (NP) form. We studied the safety of…”
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The effect of formulation on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo by Leite-Silva, Vânia R., Lamer, Marina Le, Sanchez, Washington Y., Liu, David C., Sanchez, Washington H., Morrow, Isabel, Martin, Darren, Silva, Heron D.T., Prow, Tarl W., Grice, Jeffrey E., Roberts, Michael S.

“…The use of nanoparticulate zinc oxide (ZnO-NP) in sunscreens and other cosmetic products has raised public health concerns. The two key issues are the extent…”
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Analysis of the metabolic deterioration of ex vivo skin from ischemic necrosis through the imaging of intracellular NAD(P)H by multiphoton tomography and fluorescence lifetime imaging microscopy by Sanchez, Washington Y, Prow, Tarl W, Sanchez, Washington H, Grice, Jeffrey, Roberts, Michael S

“…Ex vivo human skin has been used extensively for cosmeceutical and drug delivery studies, transplantable skin allografts, or skin flaps. However, it has a…”
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Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo by Zvyagin, Andrei V, Zhao, Xin, Gierden, Audrey, Sanchez, Washington, Ross, Justin A, Roberts, Michael S

“…Zinc oxide (ZnO-nano) and titanium dioxide nanoparticles (20 to 30 nm) are widely used in several topical skin care products, such as sunscreens. However,…”
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N-acetyl-cysteine increases cellular dysfunction in progressive chronic kidney damage after acute kidney injury by dampening endogenous antioxidant responses by Small, David M, Sanchez, Washington Y, Roy, Sandrine F, Morais, Christudas, Brooks, Heddwen L, Coombes, Jeff S, Johnson, David W, Gobe, Glenda C

“…Oxidative stress and mitochondrial dysfunction exacerbate acute kidney injury (AKI), but their role in any associated progress to chronic kidney disease (CKD)…”
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Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles by Leite-Silva, Vânia R, Liu, David C, Sanchez, Washington Y, Studier, Hauke, Mohammed, Yousuf H, Holmes, Amy, Becker, Wolfgang, Grice, Jeffrey E, Benson, Heather Ae, Roberts, Michael S

“…We assessed the effects of flexing and massage on human skin penetration and toxicity of topically applied coated and uncoated zinc oxide nanoparticles (˜75…”
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Space- and time-resolved investigation on diffusion kinetics of human skin following macromolecule delivery by microneedle arrays by Wei, Jonathan C. J., Haridass, Isha N., Crichton, Michael L., Mohammed, Yousuf H., Meliga, Stefano C., Sanchez, Washington Y., Grice, Jeffrey E., Benson, Heather A. E., Roberts, Michael S., Kendall, Mark A. F.

“…Microscale medical devices are being developed for targeted skin delivery of vaccines and the extraction of biomarkers, with the potential to revolutionise…”
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Are commercially available nanoparticles safe when applied to the skin? by Robertson, Thomas A, Sanchez, Washington Y, Roberts, Michael S

“…There are a growing number of commercial uses of nanoparticles which involve direct people contact with the potential for absorption through the skin…”
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Cellular metabolism and pore lifetime of human skin following microprojection array mediation by Haridass, Isha N., Wei, Jonathan C.J., Mohammed, Yousuf H., Crichton, Michael L., Anderson, Christopher D., Henricson, Joakim, Sanchez, Washington Y., Meliga, Stefano C., Grice, Jeffrey E., Benson, Heather A.E., Kendall, Mark A.F., Roberts, Michael S.

“…Skin-targeting microscale medical devices are becoming popular for therapeutic delivery and diagnosis. We used cryo-SEM, fluorescence lifetime imaging…”
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Intravital Multiphoton Imaging of the Kidney: Tubular Structure and Metabolism by Small, David M, Sanchez, Washington Y, Gobe, Glenda C

“…Multiphoton microscopy (MPM) allows the visualization of dynamic pathophysiological events in real time in live animals. Intravital imaging can be applied to…”
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Intravital Multiphoton Imaging of the Selective Uptake of Water-Dispersible Quantum Dots into Sinusoidal Liver Cells by Liang, Xiaowen, Grice, Jeffrey E., Zhu, Yian, Liu, David, Sanchez, Washington Y., Li, Zhen, Crawford, Darrell H. G., Le Couteur, David G., Cogger, Victoria C., Liu, Xin, Xu, Zhi Ping, Roberts, Michael S.

“…Although many studies reporting the organ‐level biodistribution of nanoparticles (NPs) in animals, very few have addressed the fate of NPs in organs at the…”
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Characterization of optical properties of ZnO nanoparticles for quantitative imaging of transdermal transport by Song, Zhen, Kelf, Timothy A, Sanchez, Washington H, Roberts, Michael S, Rička, Jaro, Frenz, Martin, Zvyagin, Andrei V

“…Widespread applications of ZnO nanoparticles (NP) in sun-blocking cosmetic products have raised safety concerns related to their potential transdermal…”
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Multiphoton fluorescence microscopy of the live kidney in health and disease by Small, David M, Sanchez, Washington Y, Roy, Sandrine, Hickey, Michael J, Gobe, Glenda C

“…The structural and functional heterogeneity of the kidney ensures a diversity of response in health and disease. Multiphoton microscopy has improved our…”
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Flexible Nanosomes (SECosomes) Enable Efficient siRNA Delivery in Cultured Primary Skin Cells and in the Viable Epidermis of Ex Vivo Human Skin by Geusens, Barbara, Van Gele, Mireille, Braat, Sien, De Smedt, Stefaan C., Stuart, Marc C. A., Prow, Tarl W., Sanchez, Washington, Roberts, Michael S., Sanders, Niek N., Lambert, Jo

“…The extent to which nanoscale‐engineered systems cross intact human skin and can exert pharmacological effects in viable epidermis is controversial. This…”
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Changes in the redox state and endogenous fluorescence of in vivo human skin due to intrinsic and photo-aging, measured by multiphoton tomography with fluorescence lifetime imaging by Sanchez, Washington Y, Obispo, Clara, Ryan, Elizabeth, Grice, Jeffrey E, Roberts, Michael S

“…Ultraviolet radiation from solar exposure is a key extrinsic factor responsible for premature skin aging (i.e., photo-aging). Recent advances using in vivo…”
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Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury by Thorling, Camilla A, Liu, Xin, Burczynski, Frank J, Fletcher, Linda M, Roberts, Michael S, Sanchez, Washington Y

“…The liver is important in the biotransformation of various drugs, where hepatic transporters facilitate uptake and excretion. Ischemia-reperfusion (I/R) injury…”
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Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles by Chandrasekaran, Navin Chandrakanth, Sanchez, Washington Y, Mohammed, Yousuf H, Grice, Jeffrey E, Roberts, Michael S, Barnard, Ross T

“…Magnesium is an important micronutrient essential for various biological processes and its deficiency has been linked to several inflammatory disorders in…”
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Quantum dot penetration into viable human skin by Prow, Tarl W., Monteiro-Riviere, Nancy A., Inman, Alfred O., Grice, Jeffrey E., Chen, Xianfeng, Zhao, Xin, Sanchez, Washington H., Gierden, Audrey, Kendall, Mark A. F., Zvyagin, Andrei V., Erdmann, Detlev, Riviere, Jim E., Roberts, Michael S.

“…Abstract Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine. In…”
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Defaunation increases the spatial clustering of lowland Western Amazonian tree communities by Bagchi, Robert, Swamy, Varun, Farfan, Jean-Paul Latorre, Terborgh, John, Vela, César I. A., Pitman, Nigel C. A., Sanchez, Washington Galiano

“…1. Declines of large vertebrates in tropical forests may reduce dispersal of tree species that rely on them, and the resulting undispersed seedlings might…”
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Selective Cleavage of Human Sex Hormone-Binding Globulin by Kallikrein-Related Peptidases and Effects on Androgen Action in LNCaP Prostate Cancer Cells by Sanchez, Washington Y, de Veer, Simon J, Swedberg, Joakim E, Hong, Eui-Ju, Reid, Janet C, Walsh, Terry P, Hooper, John D, Hammond, Geoffrey L, Clements, Judith A, Harris, Jonathan M

“…Stimulation of the androgen receptor via bioavailable androgens, including testosterone and testosterone metabolites, is a key driver of prostate development…”
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