Search Results - "Sanchez, Helmuth A"

Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity by Waissbluth, Sofia, Maass, Juan Cristóbal, Sanchez, Helmuth A, Martínez, Agustín D

“…Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of…”
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The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions by Sanchez, Helmuth A, Villone, Krista, Srinivas, Miduturu, Verselis, Vytas K

“…Mutations in the GJB2 gene, which encodes Cx26, are the most common cause of sensorineural deafness. In syndromic cases, such as keratitis-ichthyosis-deafness…”
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Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling by Flores-Muñoz, Carolina, Maripillán, Jaime, Vásquez-Navarrete, Jacqueline, Novoa-Molina, Joel, Ceriani, Ricardo, Sánchez, Helmuth A, Abbott, Ana C, Weinstein-Oppenheimer, Caroline, Brown, Donald I, Cárdenas, Ana María, García, Isaac E, Martínez, Agustín D

“…Wound healing is a dynamic process required to maintain skin integrity and which relies on the precise migration of different cell types. A key molecule that…”
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An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy by González-Casanova, Jorge, Schmachtenberg, Oliver, Martínez, Agustín D, Sanchez, Helmuth A, Harcha, Paloma A, Rojas-Gomez, Diana

“…Diabetic retinopathy (DR) is one of the main causes of vision loss in the working age population. It is characterized by a progressive deterioration of the…”
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Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions by Orellana, Juan A, Figueroa, Xavier F, Sánchez, Helmuth A, Contreras-Duarte, Susana, Velarde, Victoria, Sáez, Juan C

“…In the normal brain, cellular types that compose the neurovascular unit, including neurons, astrocytes and endothelial cells express pannexins and connexins,…”
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Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti by Abbott, Ana C, García, Isaac E, Villanelo, Felipe, Flores-Muñoz, Carolina, Ceriani, Ricardo, Maripillán, Jaime, Novoa-Molina, Joel, Figueroa-Cares, Cindel, Pérez-Acle, Tomas, Sáez, Juan C, Sánchez, Helmuth A, Martínez, Agustín D

“…Some mutations in gap junction protein Connexin 26 (Cx26) lead to syndromic deafness, where hearing impairment is associated with skin disease, like in…”
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A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function by Sanchez, Helmuth A, Kraujaliene, Lina, Verselis, Vytas K

“…Connexins (Cxs) function as gap junction (GJ) channels and hemichannels that mediate intercellular and transmembrane signaling, respectively. Here, we…”
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Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue by Contreras, Jorge E., Sánchez, Helmuth A., Véliz, Loreto P., Bukauskas, Feliksas F., Bennett, Michael V.L., Sáez, Juan C.

“…Gap junction channels and hemichannels formed of connexin subunits are found in most cell types in vertebrates. Gap junctions connect cells via channels not…”
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Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro by Eugenin, E A, Gonzalez, HE, Sanchez, HA, Branes, M C, Saez, J C

“…Connexin43 (Cx43), a gap junction protein subunit, has been previously detected in Kupffer cells (KCs) during liver inflammation, however, KCs phagocytose cell…”
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Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels by Sanchez, Helmuth A, Slavi, Nefeli, Srinivas, Miduturu, Verselis, Vytas K

“…Connexin 26 (Cx26) is a transmembrane protein that forms hexameric hemichannels that can function when unopposed or dock to form intercellular gap junction…”
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Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization by Schalper, Kurt A, Sánchez, Helmuth A, Lee, Sung C, Altenberg, Guillermo A, Nathanson, Michael H, Sáez, Juan C

“…Although alkaline pH is known to trigger Ca(2+) influx in diverse cells, no pH-sensitive Ca(2+) channel has been identified. Here, we report that extracellular…”
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Altered Inhibition of Cx26 Hemichannels by pH and Zn2+ in the A40V Mutation Associated with Keratitis-Ichthyosis-Deafness Syndrome by Sanchez, Helmuth A., Bienkowski, Rick, Slavi, Nefeli, Srinivas, Miduturu, Verselis, Vytas K.

“…Excessive opening of undocked Cx26 hemichannels in the plasma membrane is associated with disease pathogenesis in keratitis-ichthyosis-deafness (KID) syndrome…”
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Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss by Sanchez, Helmuth A, Verselis, Vytas K

“…Mutation of the GJB2 gene, which encodes the connexin 26 (Cx26) gap junction (GJ) protein, is the most common cause of hereditary, sensorineural hearing loss…”
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Redox-mediated regulation of connexin proteins; focus on nitric oxide by García, Isaac E., Sánchez, Helmuth A., Martínez, Agustín D., Retamal, Mauricio A.

“…Connexins are membrane proteins that form hemichannels and gap junction channels at the plasma membrane. Through these channels connexins participate in…”
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MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity by Waissbluth, Sofia, Martínez, Agustín D., Figueroa-Cares, Cindel, Sánchez, Helmuth A., Maass, Juan C.

“…Cisplatin appears to enter the cochlear cells through the organic cation transporter 2 (OCT2). There is recent evidence that multidrug and toxin extrusion…”
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Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells by Sánchez, Helmuth A, Orellana, Juan A, Verselis, Vytas K, Sáez, Juan C

“…Numerous cell types express functional connexin (Cx) hemichannels (HCs), and membrane depolarization and/or exposure to a divalent cation-free bathing solution…”
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Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium by Rubinos, Clio, Sánchez, Helmuth A, Verselis, Vytas K, Srinivas, Miduturu

“…The anti-malarial drug quinine and its quaternary derivative N-benzylquininium (BQ(+)) have been shown to inhibit gap junction (GJ) channels with specificity…”
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Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels by Orellana, Juan A, Sánchez, Helmuth A, Schalper, Kurt A, Figueroa, Vania, Sáez, Juan C

“…The synchronization of numerous cellular events requires complex electric and metabolic cell-cell interactions. Connexins are a family of membrane proteins…”
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Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome by Sánchez, Helmuth A, Mese, Gülistan, Srinivas, Miduturu, White, Thomas W, Verselis, Vytas K

“…Mutations in GJB2, which encodes Cx26, are one of the most common causes of inherited deafness in humans. More than 100 mutations have been identified…”
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Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium by Rubinos, Clio, Sanchez, Helmuth A, Verselis, Vytas K, Srinivas, Miduturu

“…The anti-malarial drug quinine and its quaternary derivative N-benzylquininium (BQ+) have been shown to inhibit gap junction (GJ) channels with specificity for…”
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