Search Results - "Sanchez, Carissa A."

Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett's Esophagus Cohort by Gall, Alevtina, Fero, Jutta, McCoy, Connor, Claywell, Brian C, Sanchez, Carissa A, Blount, Patricia L, Li, Xiaohong, Vaughan, Thomas L, Matsen, Frederick A, Reid, Brian J, Salama, Nina R

“…The incidence of esophageal adenocarcinoma (EAC) has increased nearly five-fold over the last four decades in the United States. Barrett's esophagus, the…”
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Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels by Martinez, Pierre, Mallo, Diego, Paulson, Thomas G., Li, Xiaohong, Sanchez, Carissa A., Reid, Brian J., Graham, Trevor A., Kuhner, Mary K., Maley, Carlo C.

“…The low risk of progression of Barrett’s esophagus (BE) to esophageal adenocarcinoma can lead to over-diagnosis and over-treatment of BE patients. This may be…”
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Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression by Paulson, Thomas G., Galipeau, Patricia C., Oman, Kenji M., Sanchez, Carissa A., Kuhner, Mary K., Smith, Lucian P., Hadi, Kevin, Shah, Minita, Arora, Kanika, Shelton, Jennifer, Johnson, Molly, Corvelo, Andre, Maley, Carlo C., Yao, Xiaotong, Sanghvi, Rashesh, Venturini, Elisa, Emde, Anne-Katrin, Hubert, Benjamin, Imielinski, Marcin, Robine, Nicolas, Reid, Brian J., Li, Xiaohong

“…While the genomes of normal tissues undergo dynamic changes over time, little is understood about the temporal-spatial dynamics of genomes in premalignant…”
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Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus by XIAOHONG LI, GALIPEAU, Patricia C, MALEY, Carlo C, SELF, Steven G, VAUGHAN, Thomas L, BLOUNT, Patricia L, REID, Brian J, PAULSON, Thomas G, SANCHEZ, Carissa A, ARNAUDO, Jessica, LIU, Karen, SATHER, Cassandra L, KOSTADINOV, Rumen L, ODZE, Robert D, KUHNER, Mary K

“…All cancers are believed to arise by dynamic, stochastic somatic genomic evolution with genome instability, generation of diversity, and selection of genomic…”
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NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma by Galipeau, Patricia C, Li, Xiaohong, Blount, Patricia L, Maley, Carlo C, Sanchez, Carissa A, Odze, Robert D, Ayub, Kamran, Rabinovitch, Peter S, Vaughan, Thomas L, Reid, Brian J

“…Somatic genetic CDKN2A, TP53, and DNA content abnormalities are common in many human cancers and their precursors, including esophageal adenocarcinoma (EA) and…”
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NSAIDs modulate clonal evolution in Barrett's esophagus by Kostadinov, Rumen L, Kuhner, Mary K, Li, Xiaohong, Sanchez, Carissa A, Galipeau, Patricia C, Paulson, Thomas G, Sather, Cassandra L, Srivastava, Amitabh, Odze, Robert D, Blount, Patricia L, Vaughan, Thomas L, Reid, Brian J, Maley, Carlo C

“…Cancer is considered an outcome of decades-long clonal evolution fueled by acquisition of somatic genomic abnormalities (SGAs). Non-steroidal anti-inflammatory…”
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Within‐patient phylogenetic reconstruction reveals early events in Barrett’s Esophagus by Smith, Lucian P., Yamato, Jon A., Galipeau, Patricia C., Paulson, Thomas G., Li, Xiaohong, Sanchez, Carissa A., Reid, Brian J., Kuhner, Mary K.

“…Barrett's Esophagus is a neoplastic condition which progresses to esophageal adenocarcinoma in 5% of cases. Key events affecting the outcome likely occur…”
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Chromosomal Instability and Copy Number Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma by PAULSON, Thomas G, MALEY, Carlo C, XIAOHONG LI, HONGZHE LI, SANCHEZ, Carissa A, CHAO, Dennis L, ODZE, Robert D, VAUGHAN, Thomas L, BLOUNT, Patricia L, REID, Brian J

“…Purpose: Chromosomal instability, as assessed by many techniques, including DNA content aneuploidy, loss of heterozygosity, and comparative genomic…”
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High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett's Esophagus by Srivastava, Amitabh, Golden, Kevin L, Sanchez, Carissa A, Liu, Karen, Fong, Pui Yee, Li, Xiaohong, Cowan, David S, Rabinovitch, Peter S, Reid, Brian J, Blount, Patricia L, Odze, Robert D

“…Goblet cells may represent a potentially successful adaptive response to acid and bile by producing a thick mucous barrier that protects against cancer…”
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Warburg and Crabtree effects in premalignant Barrett's esophagus cell lines with active mitochondria by Suchorolski, Martin T, Paulson, Thomas G, Sanchez, Carissa A, Hockenbery, David, Reid, Brian J

“…Increased glycolysis is a hallmark of cancer metabolism, yet relatively little is known about this phenotype at premalignant stages of progression. Periodic…”
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Extent of Low-Grade Dysplasia Is a Risk Factor for the Development of Esophageal Adenocarcinoma in Barrett's Esophagus by SRIVASTAVA, Amitabh, HORNICK, Jason L, XIAOHONG LI, BLOUNT, Patricia L, SANCHEZ, Carissa A, COWAN, David S, AYUB, Kamran, MALEY, Carlo C, REID, Brian J, ODZE, Robert D

“…Previous studies that evaluated extent of high-grade dysplasia (HGD) as a risk factor for esophageal adenocarcinoma (EA) in Barrett's esophagus (BE) were…”
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NSAID use and somatic exomic mutations in Barrett's esophagus by Galipeau, Patricia C, Oman, Kenji M, Paulson, Thomas G, Sanchez, Carissa A, Zhang, Qing, Marty, Jerry A, Delrow, Jeffrey J, Kuhner, Mary K, Vaughan, Thomas L, Reid, Brian J, Li, Xiaohong

“…Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations…”
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The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma by MALEY, Carlo C, GALIPEAU, Patricia C, XIAOHONG LI, SANCHEZ, Carissa A, PAULSON, Thomas G, BLOUNT, Patricia L, REID, Brian J

“…There is debate in the literature over the relative importance of genetic instability and clonal expansion during progression to cancer. Barrett's esophagus is…”
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Correction to: NSAID use and somatic exomic mutations in Barrett's esophagus by Galipeau, Patricia C, Oman, Kenji M, Paulson, Thomas G, Sanchez, Carissa A, Zhang, Qing, Marty, Jerry A, Delrow, Jeffrey J, Kuhner, Mary K, Vaughan, Thomas L, Reid, Brian J, Li, Xiaohong

“…It was highlighted that in the original article [1] the Availability of data and materials section was incorrect…”
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Cell Proliferation, Cell Cycle Abnormalities, and Cancer Outcome in Patients with Barrett's Esophagus: A Long-term Prospective Study by CHAO, Dennis L, SANCHEZ, Carissa A, GALIPEAU, Patricia C, BLOUNT, Patricia L, PAULSON, Thomas G, COWAN, David S, AYUB, Kamran, ODZE, Robert D, RABINOVITCH, Peter S, REID, Brian J

“…Purpose: Elevated cellular proliferation and cell cycle abnormalities, which have been associated with premalignant lesions, may be caused by inactivation of…”
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Deletion at fragile sites is a common and early event in Barrett's esophagus by Lai, Lisa A, Kostadinov, Rumen, Barrett, Michael T, Peiffer, Daniel A, Pokholok, Dimitry, Odze, Robert, Sanchez, Carissa A, Maley, Carlo C, Reid, Brian J, Gunderson, Kevin L, Rabinovitch, Peter S

“…Barrett's esophagus (BE) is a premalignant intermediate to esophageal adenocarcinoma, which develops in the context of chronic inflammation and exposure to…”
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p16 mutation spectrum in the premalignant condition Barrett's esophagus by Paulson, Thomas G, Galipeau, Patricia C, Xu, Lianjun, Kissel, Heather D, Li, Xiaohong, Blount, Patricia L, Sanchez, Carissa A, Odze, Robert D, Reid, Brian J

“…Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of…”
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Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs by Hadi, Kevin, Yao, Xiaotong, Behr, Julie M, Deshpande, Aditya, Xanthopoulakis, Charalampos, Tian, Huasong, Kudman, Sarah, Rosiene, Joel, Darmofal, Madison, DeRose, Joseph, Mortensen, Rick, Adney, Emily M, Shaiber, Alon, Gajic, Zoran, Sigouros, Michael, Eng, Kenneth, Wala, Jeremiah A, Wrzeszczyński, Kazimierz O, Arora, Kanika, Shah, Minita, Emde, Anne-Katrin, Felice, Vanessa, Frank, Mayu O, Darnell, Robert B, Ghandi, Mahmoud, Huang, Franklin, Dewhurst, Sally, Maciejowski, John, de Lange, Titia, Setton, Jeremy, Riaz, Nadeem, Reis-Filho, Jorge S, Powell, Simon, Knowles, David A, Reznik, Ed, Mishra, Bud, Beroukhim, Rameen, Zody, Michael C, Robine, Nicolas, Oman, Kenji M, Sanchez, Carissa A, Kuhner, Mary K, Smith, Lucian P, Galipeau, Patricia C, Paulson, Thomas G, Reid, Brian J, Li, Xiaohong, Wilkes, David, Sboner, Andrea, Mosquera, Juan Miguel, Elemento, Olivier, Imielinski, Marcin

“…Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be easily classified into simple (e.g., deletion) or complex…”
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Chromosomal Instability in Barrett's Esophagus Is Related to Telomere Shortening by FINLEY, Jennifer C, REID, Brian J, ODZE, Robert D, SANCHEZ, Carissa A, GALIPEAU, Patricia, XIAOHONG LI, SELF, Steven G, GOLLAHON, Katherine A, BLOUNT, Patricia L, RABINOVITCH, Peter S

“…Barrett's esophagus is a useful model for the study of carcinogenesis, as the metaplastic columnar epithelium that replaces squamous esophageal epithelium is…”
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Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus by Luebeck, Jens, Ng, Alvin Wei Tian, Galipeau, Patricia C., Li, Xiaohong, Sanchez, Carissa A., Katz-Summercorn, Annalise C., Kim, Hoon, Jammula, Sriganesh, He, Yudou, Lippman, Scott M., Verhaak, Roel G. W., Maley, Carlo C., Alexandrov, Ludmil B., Reid, Brian J., Fitzgerald, Rebecca C., Paulson, Thomas G., Chang, Howard Y., Wu, Sihan, Bafna, Vineet, Mischel, Paul S.

“…Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor…”
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