Ficus natalensis extract alleviates Cadmium chloride-induced testicular disruptions in albino rats

Ficus natalensis extract alleviates Cadmium chloride-induced testicular disruptions in albino rats

•CdCl2 substantially decreased the serum testosterone, sperm count, and motility.•CdCl2 downregulated the mRNA expression levels of testicular 17β-HSD and StAR.•CdCl2 induced histopathological and morphometric changes in the testis of rats.•Ficus natalensis extract attenuated oxidative damage and in...

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Bibliographic Details
Published in:Journal of trace elements in medicine and biology Vol. 70; p. 126924
Main Authors: Elish, Shaimaa E.A., Sanad, Fatma A., Baky, Mostafa H., Yasin, Noha A.E., Temraz, Abeer, El-Tantawy, Walid H.
Format: Journal Article
Language:English
Published: Germany Elsevier GmbH 01-03-2022
Subjects:
Animals
Antioxidant
Antioxidants - metabolism
Cadmium - toxicity
Cadmium Chloride - toxicity
CdCl2
Ficus
Ficus natalensis extract
Histopathology
Male
Oxidative Stress
Plant Extracts - metabolism
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Sperm count
Sperm Motility
Testis
Testosterone
Testosterone
Histopathology
Sperm count
Antioxidant
CdCl2
Ficus natalensis extract
CdCl
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Summary:•CdCl2 substantially decreased the serum testosterone, sperm count, and motility.•CdCl2 downregulated the mRNA expression levels of testicular 17β-HSD and StAR.•CdCl2 induced histopathological and morphometric changes in the testis of rats.•Ficus natalensis extract attenuated oxidative damage and inflammation caused by CdCl2.•Ficus natalensis extract significantly modulated adverse effects induced by CdCl2. Cadmium is a potential environmental pollutant with worldwide health problems. Many Ficus species are reported to have an extensive diversity of traditional uses, among them the treatment of reproductive toxicity. This study set out to evaluate the effect of Ficus natalensis extract on the testicular impairments induced by cadmium chloride (CdCl2) and investigated the potential mechanisms associated with its treatment. Thus, 40 male albino rats were categorized into 4 groups (n = 10); group I (control), group II (cadmium-treated group) orally received 5 mg/kg/day CdCl2 for one month, group III (cadmium + Ficus natalensis extract) orally received 5 mg/kg/day CdCl2 for one month plus 200 mg/kg/day Ficus natalensis extract for another month, and group IV (cadmium + reference drug (mesterolone) orally received 5 mg/kg/day CdCl2 for one month plus 4.16 mg/kg/day mesterolone for another month. At the end of experiment, CdCl2 administration markedly induced histological and histo-morphometric changes with a substantial (p < 0.05) decrease in the sperm count, sperm motility, serum TAC, serum testosterone, downregulation in the mRNA expression levels of testicular 17β-HSD and StAR, in addition to a significant increase in serum TNF-α and testicular MDA level compared to the control group. Conversely, the treatment with Ficus natalensis methanolic extract as well as the reference drug significantly ameliorated the above-mentioned adverse effects induced by CdCl2. Our results suggested that Ficus natalensis extract can attenuate the CdCl2-induced testicular impairments via inhibiting the oxidative cell damage and inflammation that contributed to CdCl2 toxicity.
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ISSN:0946-672X
1878-3252
DOI:10.1016/j.jtemb.2022.126924