Search Results - "Sana, D"

Radioimmunotherapy for the treatment of head and neck cancer by Karam, Sana D, MD, Raben, David, MD

“…SummaryEvidence to date shows that immune checkpoint inhibitors have little benefit in most patients with head and neck squamous cell carcinoma (HNSCC)…”
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Overcoming Resistance to Combination Radiation-Immunotherapy: A Focus on Contributing Pathways Within the Tumor Microenvironment by Darragh, Laurel B, Oweida, Ayman J, Karam, Sana D

“…Radiation therapy has been used for many years to treat tumors based on its DNA-damage-mediated ability to kill cells. More recently, RT has been shown to…”
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Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study by O'Sullivan, Brian, Prof, Huang, Shao Hui, MD, Su, Jie, MSc, Garden, Adam S, Prof, Sturgis, Erich M, Prof, Dahlstrom, Kristina, PhD, Lee, Nancy, Prof, Riaz, Nadeem, MD, Pei, Xin, PhD, Koyfman, Shlomo A, MD, Adelstein, David, Prof, Burkey, Brian B, Prof, Friborg, Jeppe, MD, Kristensen, Claus A, MD, Gothelf, Anita B, MD, Hoebers, Frank, MD, Kremer, Bernd, MD, Speel, Ernst-Jan, Prof, Bowles, Daniel W, MD, Raben, David, Prof, Karam, Sana D, MD, Yu, Eugene, MD, Xu, Wei, PhD

“…Summary Background Human papillomavirus-related (HPV+) oropharyngeal cancer is a rapidly emerging disease with generally good prognosis. Many prognostic…”
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Advances in the management of pancreatic cancer by Del Chiaro, Marco, Sugawara, Toshitaka, Karam, Sana D, Messersmith, Wells A

“…Pancreatic cancer remains among the malignancies with the worst outcomes. Survival has been improving, but at a slower rate than other cancers. Multimodal…”
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A comprehensive comparative analysis of treatment modalities for sinonasal malignancies by Robin, Tyler P., Jones, Bernard L., Gordon, Oren M., Phan, Andy, Abbott, Diana, McDermott, Jessica D., Goddard, Julie A., Raben, David, Lanning, Ryan M., Karam, Sana D.

“…BACKGROUND Sinonasal malignancies are a rare and heterogeneous group of tumors for which there is a paucity of robust data with which to guide management…”
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Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors by Darragh, Laurel B., Gadwa, Jacob, Pham, Tiffany T., Van Court, Benjamin, Neupert, Brooke, Olimpo, Nicholas A., Nguyen, Khoa, Nguyen, Diemmy, Knitz, Michael W., Hoen, Maureen, Corbo, Sophia, Joshi, Molishree, Zhuang, Yonghua, Amann, Maria, Wang, Xiao-Jing, Dow, Steven, Kedl, Ross M., Samedi, Von, Boss, Mary-Keara, Karam, Sana D.

“…In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective…”
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Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer by Gadwa, Jacob, Karam, Sana D.

“…The complement system consists of a collection of serum proteins that act as the main frontline effector arm of the innate immune system. Activation of…”
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The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy by Piper, Miles, Mueller, Adam C., Karam, Sana D.

“…Fibroblasts are a key component of the tumor microenvironment (TME) that can serve as a scaffold for tumor cell migration and augment the tumor's ability to…”
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Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration by Oweida, Ayman, Hararah, Mohammad K, Phan, Andy, Binder, David, Bhatia, Shilpa, Lennon, Shelby, Bukkapatnam, Sanjana, Van Court, Benjamin, Uyanga, Nomin, Darragh, Laurel, Kim, Hyun Min, Raben, David, Tan, Aik Choon, Heasley, Lynn, Clambey, Eric, Nemenoff, Raphael, Karam, Sana D

“…Radiotherapy (RT) can transform the immune landscape and render poorly immunogenic tumors sensitive to PD-L1 inhibition. Here, we established that the response…”
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Ethnic Disparities in Imaging Utilization at Diagnosis of Non-Small Cell Lung Cancer by Morgan, Rustain L, Karam, Sana D, Bradley, Cathy J

“…Abstract Background Prior research demonstrated statistically significant racial disparities related to lung cancer treatment and outcomes. We examined…”
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Amateur antigen‐presenting cells in the tumor microenvironment by Darragh, Laurel B., Karam, Sana D.

“…Presentation of tumor antigens is a critical step in producing a robust antitumor immune response. Classically tumor antigens are thought to be presented to…”
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Tuberculosis-Cancer Parallels in Immune Response Regulation by Bickett, Thomas E, Karam, Sana D

“…and cancer are two diseases with proclivity for the development of resistance to the host immune system. Mechanisms behind resistance can be host derived or…”
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STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer by Oweida, Ayman J, Darragh, Laurel, Phan, Andy, Binder, David, Bhatia, Shilpa, Mueller, Adam, Court, Benjamin Van, Milner, Dallin, Raben, David, Woessner, Richard, Heasley, Lynn, Nemenoff, Raphael, Clambey, Eric, Karam, Sana D

“…Abstract Background Radioresistance represents a major problem in the treatment of head and neck cancer (HNC) patients. To improve response, understanding…”
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Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer by Ding, Ding, Stokes, William, Eguchi, Megan, Hararah, Mohammad, Sumner, Whitney, Amini, Arya, Goddard, Julie, Somerset, Hilary, Bradley, Cathy, McDermott, Jessica, Raben, David, Karam, Sana D

“…Oral cavity squamous cell carcinoma (OCSCC) is associated with often-delayed clinical diagnosis, poor prognosis, and expensive therapeutic approaches…”
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Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer using the National Cancer Data Base by Amini, Arya, Jasem, Jagar, Jones, Bernard L, Robin, Tyler P, McDermott, Jessica D, Bhatia, Shilpa, Raben, David, Jimeno, Antonio, Bowles, Daniel W, Karam, Sana D

“…Highlights • Multimodality treatment improves OS in HPV-positive stage III–IVB disease. • AJCC stage was poorly associated with survival in HPV-positive…”
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Durvalumab in combination with chemoradiotherapy in patients with head and neck squamous cell carcinoma: Results from the Phase 1 CLOVER study by Bauman, Julie E., Karam, Sana D., O'Brien, Cathy, Mak, Gabriel, Cho, Byoung Chul

“…Background The Phase 1 CLOVER study (NCT03509012) assessed durvalumab in combination with concurrent chemoradiotherapy (cCRT) in patients with advanced solid…”
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Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma by Oweida, Ayman, Lennon, Shelby, Calame, Dylan, Korpela, Sean, Bhatia, Shilpa, Sharma, Jaspreet, Graham, Caleb, Binder, David, Serkova, Natalie, Raben, David, Heasley, Lynn, Clambey, Eric, Nemenoff, Raphael, Karam, Sana D.

“…Immunotherapy clinical trials targeting the programmed-death ligand axis (PD-1/PD-L1) show that most head and neck squamous cell carcinoma (HNSCC) patients are…”
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Measurement of mouse head and neck tumors by automated analysis of CBCT images by Van Court, Benjamin, Neupert, Brooke, Nguyen, Diemmy, Ross, Richard, Knitz, Michael W., Karam, Sana D.

“…Animal experiments are often used to determine effects of drugs and other biological conditions on cancer progression, but poor accuracy and reproducibility of…”
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The dichotomy of regulatory B cells in cancer versus allergic disease by Dang, Melissa, Yu, Justin, Galant‐Swafford, Jessica, Karam, Sana D.

“…Regulatory B cells (Bregs) are an immunosuppressive cell phenotype that affects the immune system by limiting the inflammatory cascade. Dysregulation of Bregs…”
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Vasculitis, CA19-9, and Perineural Invasion Differentially Predict Response and Surgical Outcome in Pancreatic Ductal Adenocarcinoma by Piper, Miles, Ross, Richard Blake, Hu, Junxiao, Watanabe, Shuichi, Knitz, Michael, Mehrotra, Sanjana, Shulick, Richard, Chiaro, Marco Del, Karam, Sana D.

“…Curative intent treatment of pancreatic adenocarcinoma (PDAC) relies on surgical resection. Modern treatment protocols focus on optimizing neoadjuvant therapy…”
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