Search Results - "San Wan, Soo"

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma by Gupte, Ankita, Baker, Emma K, Wan, Soo-San, Stewart, Elizabeth, Loh, Amos, Shelat, Anang A, Gould, Cathryn M, Chalk, Alistair M, Taylor, Scott, Lackovic, Kurt, Karlström, Åsa, Mutsaers, Anthony J, Desai, Jayesh, Madhamshettiwar, Piyush B, Zannettino, Andrew C W, Burns, Chris, Huang, David C S, Dyer, Michael A, Simpson, Kaylene J, Walkley, Carl R

“…Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of…”
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Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase by Ovenden, Simon P.B., Yu, Jin, San Wan, Soo, Sberna, Gian, Murray Tait, R., Rhodes, David, Cox, Susan, Coates, Jonathan, Walsh, Neville G., Meurer-Grimes, Barbara M.

“…The cyclolignan globoidnan A, which inhibits HIV integrase, was isolated from Eucalyptus globoidea. The structure of globoidnan A was solved by 2D NMR. An HTS…”
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A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis by van Delft, Mark F., Chappaz, Stephane, Khakham, Yelena, Bui, Chinh T., Debrincat, Marlyse A., Lowes, Kym N., Brouwer, Jason M., Grohmann, Christoph, Sharp, Phillip P., Dagley, Laura F., Li, Lucy, McArthur, Kate, Luo, Meng-Xiao, Chin, Hui San, Fairlie, W. Douglas, Lee, Erinna F., Segal, David, Duflocq, Stephane, Lessene, Romina, Bernard, Sabrina, Peilleron, Laure, Nguyen, Thao, Miles, Caroline, Wan, Soo San, Lane, Rachael M., Wardak, Ahmad, Lackovic, Kurt, Colman, Peter M., Sandow, Jarrod J., Webb, Andrew I., Czabotar, Peter E., Dewson, Grant, Watson, Keith G., Huang, David C. S., Lessene, Guillaume, Kile, Benjamin T.

“…Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to…”
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A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes by Rochfort, Simone, Ford, Joanne, Ovenden, Simon, Wan, Soo San, George, Samantha, Wildman, Howard, Tait, R Murray, Meurer-Grimes, Barbara, Cox, Susan, Coates, Jonathan, Rhodes, David

“…A novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes…”
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Physaloside A, an acylated sucrose ester from Physalis viscosa by Ovenden, S.P.B, Yu, J, Bernays, J, Wan, S.S, Christophidis, L.J, Sberna, G, Tait, R.M, Wildman, H.G, Lebeller, D, Lowther, J

“…Chemical investigations of the crude MeOH extract of Physalis viscosa led to the identification of the novel acylated sucrose ester physaloside A (1). The…”
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Mechanistic insights into complement pathway inhibition by CR1 domain duplication by Wymann, Sandra, Nair, Anup G., Ewert, Svenja, Powers, Glenn A., Wan, Soo San, Pelzing, Matthias, Baz Morelli, Adriana, Rowe, Tony, Hardy, Matthew P.

“…Complement receptor 1 (CR1) is a membrane glycoprotein with a highly duplicated domain structure able to bind multiple ligands such as C3b and C4b, the…”
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Systematic Mapping of Potential Binding Sites for Shc and Grb2 SH2 Domains on Insulin Receptor Substrate-1 and the Receptors for Insulin, Epidermal Growth Factor, Platelet-derived Growth Factor, and Fibroblast Growth Factor (∗) by Ward, Colin W., Gough, Keith H, Rashke, Melisa, Wan, Soo San, Tribbick, Gordon, Wang, Jian-xin

“…Multipin peptide synthesis has been employed to produce biotinylated 11-mer phosphopeptides that account for every tyrosine residue in insulin receptor…”
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Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype by Lahoud, Mireille H, Ahmet, Fatma, Kitsoulis, Susie, Wan, Soo San, Vremec, David, Lee, Chin-Nien, Phipson, Belinda, Shi, Wei, Smyth, Gordon K, Lew, Andrew M, Kato, Yu, Mueller, Scott N, Davey, Gayle M, Heath, William R, Shortman, Ken, Caminschi, Irina

“…Three surface molecules of mouse CD8(+) dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated…”
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Trichomycins A and B:  Antibacterial Triterpenes from the New Species Tricholoma sp. AU1 by Ovenden, Simon P. B, Yu, Jin, Bernays, Jill, Wan, Soo San, Christophidis, Larissa J, Sberna, Gian, Tait, R. Murray, Wildman, Howard G, Lebeller, Dominique, Platel, Denis, May, Tom W, Meurer-Grimes, Barbara M

“…To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their…”
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The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments by Zhang, Jian-Guo, Czabotar, Peter E., Policheni, Antonia N., Caminschi, Irina, San Wan, Soo, Kitsoulis, Susie, Tullett, Kirsteen M., Robin, Adeline Y., Brammananth, Rajini, van Delft, Mark F., Lu, Jinhua, O'Reilly, Lorraine A., Josefsson, Emma C., Kile, Benjamin T., Chin, Wei Jin, Mintern, Justine D., Olshina, Maya A., Wong, Wilson, Baum, Jake, Wright, Mark D., Huang, David C.S., Mohandas, Narla, Coppel, Ross L., Colman, Peter M., Nicola, Nicos A., Shortman, Ken, Lahoud, Mireille H.

“…The immune system must distinguish viable cells from cells damaged by physical and infective processes. The damaged cell-recognition molecule Clec9A is…”
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Exploiting the Biginelli reaction: nitrogen-rich pyrimidine-based tercyclic α-helix mimetics by Lim, Zelong, Duggan, Peter J., Wan, Soo San, Lessene, Guillaume, Meyer, Adam G., Tuck, Kellie L.

“…Several rationally designed pyrimidine-based scaffolds intended to mimic the spatial projection of the i, i+3, and i+7 residues of an α-helix and also possess…”
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Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9 by Phillipson, Louisa J., Segal, David H., Nero, Tracy L., Parker, Michael W., Wan, Soo San, de Silva, Melanie, Guthridge, Mark A., Wei, Andrew H., Burns, Christopher J.

“…[Display omitted] The serine–threonine kinase CDK9 is a target of emerging interest for the development of anti-cancer drugs. There are multiple lines of…”
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Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS by Burns, Christopher J., Harte, Michael F., Bu, Xianyong, Fantino, Emmanuelle, Giarrusso, Marilena, Joffe, Max, Kurek, Margarita, Legge, Fiona S., Razzino, Pasquale, Su, Stephen, Treutlein, Herbert, Wan, Soo San, Zeng, Jun, Wilks, Andrew F.

“…A novel series of 2-(α-methylbenzylamino) pyrazines have been synthesized and shown to be potent inhibitors of the FMS tyrosine receptor kinase. A series of…”
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Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1 by Ovenden, Simon P B, Yu, Jin, Bernays, Jill, Wan, Soo San, Christophidis, Larissa J, Sberna, Gian, Tait, R Murray, Wildman, Howard G, Lebeller, Dominique, Platel, Denis, May, Tom W, Meurer-Grimes, Barbara M

“…To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their…”
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Physaloside A, an Acylated Sucrose Ester from Physalis v iscosa by Ovenden, Simon P. B, Yu, Jin, Bernays, Jill, Wan, Soo San, Christophidis, Larissa J, Sberna, Gian, Tait, R. Murray, Wildman, Howard G, Lebeller, Dominique, Lowther, John, Walsh, Neville G, Meurer-Grimes, Barbara M

“…Chemical investigations of the crude MeOH extract of Physalis viscosa led to the identification of the novel acylated sucrose ester physaloside A (1). The…”
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Trichomycins A and B:  Antibacterial Triterpenes from the New Species Tricholoma sp. AU1 by Ovenden, Simon P. B, Yu, Jin, Bernays, Jill, Wan, Soo San, Christophidis, Larissa J, Sberna, Gian, Tait, R. Murray, Wildman, Howard G, Lebeller, Dominique, Platel, Denis, May, Tom W, Meurer-Grimes, Barbara M

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