Search Results - "San Tan, Gek"

Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer by Lai, Gillianne G Y, Lim, Tse Hui, Lim, John, Liew, Perry J R, Kwang, Xue Lin, Nahar, Rahul, Aung, Zaw Win, Takano, Angela, Lee, Yin Yeng, Lau, Dawn P X, Tan, Gek San, Tan, Sze Huey, Tan, Wan Ling, Ang, Mei-Kim, Toh, Chee Keong, Tan, Bien Soo, Devanand, Anantham, Too, Chow Wei, Gogna, Apoorva, Ong, Boon Hean, Koh, Tina P T, Kanesvaran, Ravindran, Ng, Quan Sing, Jain, Amit, Rajasekaran, Tanujaa, Yuan, Ju, Lim, Tony Kiat Hon, Lim, Alvin S T, Hillmer, Axel M, Lim, Wan Teck, Iyer, N Gopalakrishna, Tam, Wai Leong, Zhai, Weiwei, Tan, Eng-Huat, Tan, Daniel S W

“…Mesenchymal epithelial transition factor ( MET) activation has been implicated as an oncogenic driver in epidermal growth factor receptor ( EGFR)-mutant…”
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Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer by Seeber, Andreas, Battaglin, Francesca, Zimmer, Kai, Kocher, Florian, Baca, Yasmine, Xiu, Joanne, Spizzo, Gilbert, Novotny-Diermayr, Veronica, Rieder, Dietmar, Puccini, Alberto, Swensen, Jeff, Ellis, Michelle, Goldberg, Richard M, Grothey, Axel, Shields, Anthony F, Marshall, John L, Weinberg, Benjamin A, Sackstein, Paul E, Lim, Kiat Hon, Tan, Gek San, Nabhan, Chadi, Korn, W Michael, Amann, Arno, Trajanoski, Zlatko, Berger, Martin D, Lou, Emil, Wolf, Dominik, Lenz, Heinz-Josef

“…Gene fusions involving R-spondin (RSPOfp) and RNF43 mutations have been shown to drive Wnt-dependent tumor initiation in colorectal cancer. Herein, we aimed to…”
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Comparison of tissue and molecular yield between fine-needle biopsy (FNB) and fine-needle aspiration (FNA): a randomized study by Asokkumar, Ravishankar, Yung Ka, Chin, Loh, Tracy, Kah Ling, Lim, Gek San, Tan, Ying, Hao, Tan, Damien, Khor, Christopher, Lim, Tony, Soetikno, Roy

“…Abstract Background and study aims Recently, a new Franseen design endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) needle was developed with the goal…”
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Ciliated muconodular papillary tumor: a solitary peripheral lung nodule in a teenage girl by Lau, Kah Weng, MBBS, DPhil (Oxon), Aubry, Marie-Christine, MD, Tan, Gek San, MSc, Lim, Chong Hee, MBBS, FRCSEd, Takano, Angela Maria, MD

“…Summary Papillary tumors of the peripheral lung containing ciliated cells and extracellular mucin include solitary peripheral ciliated glandular papilloma,…”
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Brief Report: Droplet Digital Polymerase Chain Reaction Versus Plasma Next-Generation Sequencing in Detecting Clearance of Plasma EGFR Mutations and Carcinoembryonic Antigen Levels as a Surrogate Measure by Saw, Stephanie P L, Tan, Gek San, Tan, Wei Chong, Tan, Aaron C, Lai, Gillianne G Y, Lim, Darren W T, Kanesvaran, Ravindran, Tan, Wan Ling, Tan, Sze Huey, Lim, Kiat Hon, Skanderup, Anders J, Tan, Daniel S W

“…To compare the performance of droplet digital polymerase chain reaction (ddPCR) and plasma next-generation sequencing (NGS) in detecting clearance of plasma…”
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Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition by Whiteman, Matthew, Rose, Peter, Siau, Jia Ling, Cheung, Nam Sang, Tan, Gek San, Halliwell, Barry, Armstrong, Jeffrey S.

“…Liver cirrhosis is often preceded by overt signs of hepatitis, including parenchymal cell inflammation and infiltration of polymorphonuclear (PMN) leukocytes…”
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Novel Therapies for Metastatic Non-Small Cell Lung Cancer with MET Exon 14 Alterations: A Spotlight on Capmatinib by Tan, Aaron C, Loh, Tracy J, Kwang, Xue Lin, Tan, Gek San, Lim, Kiat Hon, Tan, Daniel S W

“…MET exon 14 (METex14) alterations are now an established therapeutically tractable target in non-small cell lung cancer (NSCLC). Recently reported trials of…”
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2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver carcinogenesis by Zubaidah, Ramdzan M, Tan, Gek San, Tan, Sandra B.E, Lim, Seng Gee, Lin, Qingsong, Chung, Maxey C.M

“…Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide and is often characterized by aggressive tumour behaviour and poor prognosis. One of the…”
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Individualized Molecular Profiling for Allocation to Clinical Trials Singapore Study-An Asian Tertiary Cancer Center Experience by Seet, Amanda O L, Tan, Aaron C, Tan, Tira J, Ng, Matthew C H, Tai, David W M, Lam, Justina Y C, Tan, Gek San, Gogna, Apoorva, Too, Chow Wei, Tan, Bien Soo, Takano, Angela, Lim, Alvin, Lim, Tse Hui, Lim, Soon Thye, Dent, Rebecca Alexandra, Ang, Mei Kim, Yap, Yoon-Sim, Tan, Iain B H, Choo, Su Pin, Toh, Chee Keong, Lim, Elaine H, Farid, Mohamad, Skanderup, Anders Jacobsen, Iyer, N Gopalakrishna, Lim, Wan Teck, Tan, Eng Huat, Lim, Tony K H, Tan, Daniel S W

“…Precision oncology has transformed the management of advanced cancers through implementation of advanced molecular profiling technologies to identify…”
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Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma by Tan, Daniel S W, Chong, Fui Teen, Leong, Hui Sun, Toh, Shen Yon, Lau, Dawn P, Kwang, Xue Lin, Zhang, Xiaoqian, Sundaram, Gopinath M, Tan, Gek San, Chang, Mei Mei, Chua, Boon Tin, Lim, Wan Teck, Tan, Eng Huat, Ang, Mei Kim, Lim, Tony K H, Sampath, Prabha, Chowbay, Balram, Skanderup, Anders J, DasGupta, Ramanuj, Iyer, N Gopalakrishna

“…A silent single-nucleotide variant (SNV) affecting the transcription of a long noncoding RNA (lncRNA EGFR-AS1) within the EGFR coding region alters the EGFR…”
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Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis by Tan, Aaron C., Lai, Gillianne G.Y., Tan, Gek San, Poon, Shou Yu, Doble, Brett, Lim, Tse Hui, Aung, Zaw Win, Takano, Angela, Tan, Wan Ling, Ang, Mei-Kim, Tan, Bien Soo, Devanand, Anantham, Too, Chow Wei, Gogna, Apoorva, Ong, Boon-Hean, Koh, Tina P.T., Kanesvaran, Ravindran, Ng, Quan Sing, Jain, Amit, Rajasekaran, Tanujaa, Lim, Alvin S.T., Lim, Wan Teck, Toh, Chee Keong, Tan, Eng-Huat, Lim, Tony Kiat Hon, Tan, Daniel S.W.

“…•Upfront NGS is feasible and cost-effective in an EGFR mutant predominant population.•Characterizing the wider genomic profile may yield important…”
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Microfluidic enrichment for the single cell analysis of circulating tumor cells by Yeo, Trifanny, Tan, Swee Jin, Lim, Chew Leng, Lau, Dawn Ping Xi, Chua, Yong Wei, Krisna, Sai Sakktee, Iyer, Gopal, Tan, Gek San, Lim, Tony Kiat Hon, Tan, Daniel S.W., Lim, Wan-Teck, Lim, Chwee Teck

“…Resistance to drug therapy is a major concern in cancer treatment. To probe clones resistant to chemotherapy, the current approach is to conduct pooled cell…”
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Comparison of an amplicon-based large panel next generation sequencing (NGS) assay with conventional testing methods for MET and HER2 amplification in lung and breast cancers by Tay, Timothy Kwang Yong, Tan, Gek San, Lee, Say Hwee, Sam, Xin Xiu, Lim, Tse Hui, Ng, Jeremy Wee Kiat, Tan, Daniel Shao Weng, Lim, Tony Kiat Hon

“…The frequency of MET and HER2 amplification being detected by next generation sequencing (NGS) is increasing due to NGS being increasingly adopted for…”
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Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas by Chan, Sock Hoai, Lim, Weng Khong, Ishak, Nur Diana Binte, Li, Shao-Tzu, Goh, Wei Lin, Tan, Gek San, Lim, Kiat Hon, Teo, Melissa, Young, Cedric Ng Chuan, Malik, Simeen, Tan, Mann Hong, Teh, Jonathan Yi Hui, Chin, Francis Kuok Choon, Kesavan, Sittampalam, Selvarajan, Sathiyamoorthy, Tan, Patrick, Teh, Bin Tean, Soo, Khee Chee, Farid, Mohamad, Quek, Richard, Ngeow, Joanne

“…Associations of sarcoma with inherited cancer syndromes implicate genetic predisposition in sarcoma development. However, due to the apparently sporadic nature…”
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P190: Validation of myeloid neoplasm next generation sequencing panel for acute myeloid leukemia and myeloid malignancies in Singapore by Hein, Than, Khoo, Si Jie, San Tan, Gek, Chuah, Charles, Lim, Tony, How, Gee Fung

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Gene profiling reveals hydrogen sulphide recruits death signaling via the N-methyl-D-aspartate receptor identifying commonalities with excitotoxicity by Chen, Minghui Jessica, Peng, Zhao Feng, Manikandan, Jayapal, Melendez, Alirio J., Tan, Gek San, Chung, Ching Ming, Li, Qiu-Tian, Tan, Theresa M., Deng, Lih Wen, Whiteman, Matthew, Beart, Philip M., Moore, Phillip K., Cheung, Nam Sang

“…Recently the role of hydrogen sulphide (H2S) as a gasotransmitter stimulated wide interest owing to its involvement in Alzheimer's disease and ischemic stroke…”
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Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome‐Wide Association Study in Multiple Cohorts by Guo, Yun‐Miao, Chen, Jie‐Rong, Feng, Yan‐Chun, Chua, Melvin L. K., Zeng, Yanni, Hui, Edwin Pun, Chan, Allen K. C., Tang, Lin‐Quan, Wang, Lin, Cui, Qian, Han, Hui‐Qiong, Luo, Chun‐Ling, Lin, Guo‐Wang, Liang, Yan, Liu, Yang, He, Zhong‐Lian, Liu, Yu‐Xiang, Wei, Pan‐Pan, Liu, Chu‐Jun, Peng, Wan, Han, Bo‐Wei, Zuo, Xiao‐Yu, Ong, Enya H. W., Yeo, Eugenia L. L., Low, Kar Perng, Tan, Gek San, Lim, Tony K. H., Hwang, Jacqueline S. G., Li, Bo, Feng, Qi‐Sheng, Xia, Xiaojun, Xia, Yun‐Fei, Ko, Josephine, Dai, Wei, Lung, Maria L., Chan, Anthony T. C., Lo, Dennis Y. M., Zeng, Mu‐Sheng, Mai, Hai‐Qiang, Liu, Jianjun, Zeng, Yi‐Xin, Bei, Jin‐Xin

“…Germline polymorphisms are linked with differential survival outcomes in cancers but are not well studied in nasopharyngeal carcinoma (NPC). Here, a two‐phase…”
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Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry by Liang, Cynthia R. M. Y., Leow, Chon Kar, Neo, Jason C. H., Tan, Gek San, Lo, Siaw Ling, Lim, Justin W. E., Seow, Teck Keong, Lai, Paul B. S., Chung, Maxey C. M.

“…Proteome analysis of human hepatocellular carcinoma tissues was conducted using two‐dimensional difference gel electrophoresis coupled with mass spectrometry…”
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Proteome database of hepatocellular carcinoma by Liang, Rosa C.M.Y, Neo, Jason C.H, Ling Lo, Siaw, San Tan, Gek, Keong Seow, Teck, Chung, Maxey C.M

“…Hepatocellular carcinoma (HCC or hepatoma) is the most common primary cancer of the liver. Persistent viral infection by the hepatic B or C virus is probably…”
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Molecular characterization of hepatitis B virus surface antigen mutants in Singapore patients with hepatocellular carcinoma and hepatitis B virus carriers negative for HBsAg but positive for anti-HBs and anti-HBc by OON, CHONG JIN, CHEN, WEI NING, GOH, KEE TAI, MESENAS, STEVEN, NG, HAN SEONG, CHIANG, GILBERT, TAN, CLARENCE, KOH, SHIUAN, TENG, SIAW WEI, TOH, IVY, MOH, MEI CHUNG, GOO, KIAN SIM, TAN, KAELING, LEONG, AI LIN, TAN, GEK SAN

“…Background and Aims : Mutations on the a‐determinant of hepatitis B virus surface antigen (HBsAg), capable of escaping detection and vaccination, are…”
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