Search Results - "San Millán, José L."

The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome by Escobar-Morreale, Héctor F, Luque-Ramírez, Manuel, San Millán, José L

“…The genetic mechanisms underlying functional hyperandrogenism and the polycystic ovary syndrome (PCOS) remain largely unknown. Given the large number of…”
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Effects of Polycystic Ovary Syndrome (PCOS), Sex Hormones, and Obesity on Circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 Expression by Murri, Mora, Insenser, María, Fernández-Durán, Elena, San-Millán, José L, Escobar-Morreale, Héctor F

“…Context: MicroRNAs (miRNAs) are small, noncoding RNA sequences that negatively regulate gene expression at the post-transcriptional level. miRNA-21, miRNA-27b,…”
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The Polycystic Ovary Syndrome Associated with Morbid Obesity May Resolve after Weight Loss Induced by Bariatric Surgery by Escobar-Morreale, Héctor F., Botella-Carretero, José I., Álvarez-Blasco, Francisco, Sancho, José, San Millán, José L.

“…Context: The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially…”
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Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome by Cortón, Marta, Botella-Carretero, José I., Benguría, Alberto, Villuendas, Gemma, Zaballos, Angel, San Millán, José L., Escobar-Morreale, Héctor F., Peral, Belén

“…Context: The polycystic ovary syndrome (PCOS) is frequently associated with visceral obesity, suggesting that omental adipose tissue might play an important…”
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A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia among Women Presenting with Hyperandrogenic Symptoms and Signs by Escobar-Morreale, Héctor F., Sanchón, Raul, San Millán, José L.

“…Context: The diagnosis of the polycystic ovary syndrome requires the exclusion of nonclassical congenital adrenal hyperplasia (NCAH). Objective: Our objective…”
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Body Iron Stores and Glucose Intolerance in Premenopausal Women: Role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism by Martínez-García, M. Ángeles, Luque-Ramírez, Manuel, San-Millán, José L, Escobar-Morreale, Héctor F

“…OBJECTIVE: Increased serum ferritin levels and iron stores may be involved in the development of abnormal glucose tolerance in women presenting with obesity…”
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Proteomic Analysis of Plasma in the Polycystic Ovary Syndrome Identifies Novel Markers Involved in Iron Metabolism, Acute-Phase Response, and Inflammation by Insenser, María, Martínez-García, M. Ángeles, Montes, Rafael, San-Millán, José L., Escobar-Morreale, Héctor F.

“…Context: Hypothesis-free approaches such as proteomic analysis may identify novel biomarkers for disease. Objective: The objective of the study was to compare…”
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Increased Body Iron Stores of Obese Women With Polycystic Ovary Syndrome Are a Consequence of Insulin Resistance and Hyperinsulinism and Are Not a Result of Reduced Menstrual Losses by LUQUE-RAMIREZ, Manuel, SANCHON, Raul, ALVAREZ-BLASCO, Francisco, SAN MILLAN, Jose L, BOTELLA-CARRETERO, Jose I, ESCOBAR-MORREALE, Hector F

“…OBJECTIVE:--Increased serum ferritin levels, indicating increased body iron stores, have been found in overweight and obese women with polycystic ovary…”
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The role of genetic variation in peroxisome proliferator-activated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence by San-Millán, José L., Escobar-Morreale, Héctor F.

“…Summary Objective  To study the association of polymorphisms in the genes encoding peroxisome proliferator‐activated receptors (PPARs) with the polycystic…”
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Serum Interleukin-18 Concentrations Are Increased in the Polycystic Ovary Syndrome: Relationship to Insulin Resistance and to Obesity by Escobar-Morreale, Héctor F., Botella-Carretero, José I., Villuendas, Gemma, Sancho, José, San Millán, José L.

“…Low-grade chronic inflammation is involved in the pathogenesis of the metabolic syndrome and atherosclerosis, and serum levels of inflammatory cytokines are…”
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Association of the Polycystic Ovary Syndrome with Genomic Variants Related to Insulin Resistance, Type 2 Diabetes Mellitus, and Obesity by San Millán, José L., Cortón, Marta, Villuendas, Gemma, Sancho, José, Peral, Belén, Escobar-Morreale, Héctor F.

“…We have evaluated the possible association of polycystic ovary syndrome (PCOS) with 15 genomic variants previously described to influence insulin resistance,…”
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Abdominal adiposity and the polycystic ovary syndrome by Escobar-Morreale, Héctor F, Millán, José L. San

“…Abdominal adiposity, overweightness and obesity are frequently present in patients with polycystic ovary syndrome (PCOS). A large body of evidence suggests…”
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Non-targeted profiling of circulating microRNAs in women with polycystic ovary syndrome (PCOS): effects of obesity and sex hormones by Murri, Mora, Insenser, María, Fernández-Durán, Elena, San-Millán, José L., Luque-Ramírez, Manuel, Escobar-Morreale, Héctor F.

“…Circulating micro-ribonucleic acids (miRNAs) are small noncoding RNA molecules that influence gene transcription. We conducted the present profiling study to…”
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Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women by Alvarez-Blasco, Francisco, Martínez-García, Ma Angeles, Luque-Ramírez, Manuel, Parraza, Naiara, San Millán, José L, Escobar-Morreale, Héctor F

“…Hp(2) alleles of the haptoglobin alpha-chain polymorphism reduce the anti-oxidant properties and increase the pro-inflammatory actions of this acute-phase…”
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The Methionine 196 Arginine Polymorphism in Exon 6 of the TNF Receptor 2 Gene (TNFRSF1B) Is Associated with the Polycystic Ovary Syndrome and Hyperandrogenism by Peral, Belén, San Millán, José L., Castello, Roberto, Moghetti, Paolo, Escobar-Morreale, Héctor F.

“…Inflammatory cytokines such as TNFα may play a role in the pathogenesis of common metabolic disorders, including hyperandrogenism and the polycystic ovary…”
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Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls by Villuendas, Gemma, Botella-Carretero, José I., Roldán, Belén, Sancho, José, Escobar-Morreale, Héctor F., Millán, José L. San

“…BACKGROUND: We aimed to evaluate the influence of the Gly972Arg variant of the insulin receptor substrate-1 gene (IRS-1) and the Gly1057Asp variant in IRS-2 on…”
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Body Iron Stores Are Increased in Overweight and Obese Women With Polycystic Ovary Syndrome by Escobar-Morreale, Héctor F, Luque-Ramírez, Manuel, Álvarez-Blasco, Francisco, Botella-Carretero, José I, Sancho, José, San Millán, José L

“…Given that insulin resistance and an increased risk of type 2 diabetes are frequent in patients with polycystic ovary syndrome (PCOS), Escobar-Morreale et al…”
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A Study of the Hexose-6-Phosphate Dehydrogenase Gene R453Q and 11β-Hydroxysteroid Dehydrogenase Type 1 Gene 83557insA Polymorphisms in the Polycystic Ovary Syndrome by San Millán, José L., Botella-Carretero, José I., Álvarez-Blasco, Francisco, Luque-Ramírez, Manuel, Sancho, José, Moghetti, Paolo, Escobar-Morreale, Héctor F.

“…Context: The R453Q variant in the hexose-6-phosphate dehydrogenase gene (H6PD) and 83557insA mutations in 11β-hydroxysteroid dehydrogenase (11βHSD) type 1 gene…”
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Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome by Esteve, Eduardo, Villuendas, Gemma, Mallolas, Judith, Vendrell, Joan, López-Bermejo, Abel, Rodríguez, Matilde, Recasens, Mónica, Ricart, Wifredo, San Millán, José L., Escobar-Morreale, Héctor, Richart, Cristóbal, Fernández-Real, José Manuel

“…Summary Objective  Low‐grade inflammation has been related to obesity, insulin resistance and the metabolic syndrome. The Asp358Ala variant and the CA‐repeat…”
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Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women by Alvarez-Blasco, Francisco, Botella-Carretero, José I, San Millán, José L, Escobar-Morreale, Héctor F

“…Surprisingly, the prevalence of polycystic ovary syndrome (PCOS) in otherwise unselected overweight or obese women is unknown, despite obesity being frequent…”
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