Search Results - "San Mateo, Lani R."

Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice by Stowell, Nicole C, Seideman, Jonathan, Raymond, Holly A, Smalley, Karen A, Lamb, Roberta J, Egenolf, Devon D, Bugelski, Peter J, Murray, Lynne A, Marsters, Paul A, Bunting, Rachel A, Flavell, Richard A, Alexopoulou, Lena, San Mateo, Lani R, Griswold, Don E, Sarisky, Robert T, Mbow, M Lamine, Das, Anuk M

“…The immune mechanisms associated with infection-induced disease exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has an…”
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Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice by Wu, Linda H, Huang, C. Chris, Adhikarakunnathu, Sree, San Mateo, Lani R, Duffy, Karen E, Rafferty, Patricia, Bugelski, Peter, Raymond, Holly, Deutsch, Heather, Picha, Kristen, Ward, Christine K, Alexoupolou, Lena, Flavell, Richard A, Mbow, M. Lamine, Susulic, Vedrana S

“…Abstract Objective Emerging evidence suggests a link between innate immunity and development of type 2 diabetes mellitus (T2D); however, the molecular…”
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Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure by Luo, Jinquan, Obmolova, Galina, Malia, Thomas J., Wu, Sheng-Jiun, Duffy, Karen E., Marion, James D., Bell, Jessica K., Ge, Peng, Zhou, Z. Hong, Teplyakov, Alexey, Zhao, Yonghong, Lamb, Roberta J., Jordan, Jarrat L., San Mateo, Lani R., Sweet, Raymond W., Gilliland, Gary L.

“…Toll-like receptor 3 (TLR3) recognizes dsRNA and initiates an innate immune response through the formation of a signaling unit (SU) composed of one…”
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Interleukin-18 enhances Th1 immunity and tumor protection of a DNA vaccine by Marshall, Deborah J., Rudnick, Kelly A., McCarthy, Stephen G., Mateo, Lani R. San, Harris, Michael C., McCauley, Christine, Snyder, Linda A.

“…DNA vaccines show efficacy in many preclinical models, but these results have not yet translated to consistent clinical efficacy. Co-administration of…”
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A pathway analysis of poly(I:C)-induced global gene expression change in human peripheral blood mononuclear cells by Huang, C. Chris, Duffy, Karen E, San Mateo, Lani R, Amegadzie, Bernard Y, Sarisky, Robert T, Mbow, M. Lamine

“…Centocor Research & Development, Incorporated, Malvern, Pennsylvania To gain global pathway perspective of ex vivo viral infection models using human…”
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A Superoxide Dismutase C Mutant of Haemophilus ducreyi Is Virulent in Human Volunteers by BONG, Cliffton T. H, FORTNEY, Kate R, KATZ, Barry P, HOOD, Antoinette F, SAN MATEO, Lani R, KAWULA, Thomas H, SPINOLA, Stanley M

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Down modulation of human TLR3 function by a monoclonal antibody by Duffy, Karen E., Lamb, Roberta J., San Mateo, Lani R., Jordan, Jarrat L., Canziani, Gabriela, Brigham-Burke, Michael, Korteweg, Jeremy, Cunningham, Mark, Beck, Heena Solanki, Carton, Jill, Giles-Komar, Jill, Duchala, Cynthia, Sarisky, Robert T., Mbow, M. Lamine

“…Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in…”
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A Humoral Immune Response Confers Protection against Haemophilus ducreyi Infection by COLE, Leah E, TOFFER, Kristen L, FULCHER, Robert A, SAN MATEO, Lani R, ORNDORFF, Paul E, KAWULA, Thomas H

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Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro by Bunting, Rachel A., Duffy, Karen E., Lamb, Roberta J., San Mateo, Lani R., Smalley, Karen, Raymond, Holly, Liu, Xuesong, Petley, Ted, Fisher, Jamie, Beck, Heena, Flavell, Richard A., Alexopoulou, Lena, Ward, Christine K.

“…Toll-like receptor 3 (TLR3) binds and signals in response to dsRNA and poly(I:C), a synthetic double stranded RNA analog. Activation of TLR3 triggers innate…”
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Perforin-Mediated CTL Cytolysis Counteracts Direct Cell-Cell Spread of Listeria monocytogenes by San Mateo, Lani R, Chua, Ming Ming, Weiss, Susan R, Shen, Hao

“…The immune system has evolved various effector cells and functions to combat diverse infectious agents equipped with different virulence strategies. CD8 T…”
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Induction of Th1-type immunity and tumor protection with a prostate-specific antigen DNA vaccine by MARSHALL, Deborah J, SAN MATEO, Lani R, RUDNICK, Kelly A, MCCARTHY, Stephen G, HARRIS, Michael C, MCCAULEY, Christine, SCHANTZ, Allen, DONG GENG, CAWOOD, Pam, SNYDER, Linda A

“…Prostate specific antigen (PSA) is a serum marker that is widely used in the detection and monitoring of prostate cancer. Though PSA is a self-antigen, T cell…”
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Activation of Antigen-Specific CD8 T Cells Results in Minimal Killing of Bystander Bacteria by Jiang, Jiu, Zenewicz, Lauren A, San Mateo, Lani R, Lau, Lisa L, Shen, Hao

“…Memory CD8 T cells play a critical role in protective immunity against intracellular pathogens. In addition to their ability to specifically recognize and lyse…”
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Neutropenia Restores Virulence to an Attenuated Cu,Zn Superoxide Dismutase-Deficient Haemophilus ducreyi Strain in the Swine Model of Chancroid by SAN MATEO, L. R, TOFFER, K. L, ORNDORFF, P. E, KAWULA, T. H

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The sodA gene of Haemophilus ducreyi encodes a hydrogen peroxide-inhibitable superoxide dismutase by San Mateo, Lani R, Toffer, Kristen L, Kawula, Thomas H

“…Haemophilus ducreyi is the etiologic agent of the sexually transmitted disease chancroid, an ulcerative condition implicated in increased HIV transmission…”
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Immune Cells Are Required for Cutaneous Ulceration in a Swine Model of Chancroid by SAN MATEO, L. R, TOFFER, K. L, ORNDORFF, P. E, KAWULA, T. H

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Intranasal administration of poly (I:C) modulates cell‐associated levels of TLR3 in the lungs of C57BL/6 mice by Bunting, Rachel A, Achuthanandam, Ram, Lamb, Roberta J, Stowell, Nicole, Yao, Zhengbin, Sarisky, Robert T, Cunningham, Mark, San Mateo, Lani R, Ward, Christine K

“…Poly (I:C) (PIC) is a synthetic dsRNA analog recognized by Toll‐like receptor 3 (TLR3). The functional significance of surface vs. intracellular TLR3 has not…”
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Periplasmic copper–zinc superoxide dismutase protects Haemophilus ducreyi from exogenous superoxide by San Mateo, Lani R., Hobbs, Marcia M., Kawula, Thomas H.

“…Haemophilus ducreyi causes chancroid, a sexually transmitted genital ulcer disease implicated in increased heterosexual transmission of HIV. As part of an…”
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