Swine model of Haemophilus ducreyi infection

Haemophilus ducreyi is a strict human pathogen that causes sexually transmitted genital ulcer disease. We infected domestic swine with H. ducreyi 35000, resulting in the development of cutaneous ulcers histologically resembling human chancroid lesions. Intraepidermal lesions progressed from pustules...

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Bibliographic Details
Published in:	Infection and Immunity Vol. 63; no. 8; pp. 3094 - 3100
Main Authors:	Hobbs, M.M. (University of North Carolina School of Medicine, Chapel Hill, NC.), San Mateo, L.R, Orndorff, P.E, Almond, G, Kawula, T.H
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-08-1995
Subjects:	Animals Antibodies, Bacterial - immunology Bacterial diseases Bacterial Proteins - immunology Biological and medical sciences CERDO Chancroid - microbiology Chancroid - pathology Chancroid - physiopathology COMPORTAMIENTO SEXUAL COMPORTEMENT SEXUEL Disease Models, Animal Ear ENFERMEDADES DEL APARATO GENITAL ENFERMEDADES INFECCIOSAS Experimental bacterial diseases and models Female Haemophilus ducreyi Haemophilus ducreyi - immunology Haemophilus ducreyi - pathogenicity Infectious diseases LESION LESIONES MALADIE DE L'APPAREIL GENITAL MALADIE INFECTIEUSE Male Medical sciences MODELE MODELE ANIMAL MODELOS MODELOS ANIMALES PORCIN Swine Animal model Pathogenesis Pig Infection Pasteurellaceae Vertebrata Experimental disease Mammalia Chancroid Bacteriosis Bacteria Artiodactyla Ungulata Haemophilus ducreyi
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Summary:	Haemophilus ducreyi is a strict human pathogen that causes sexually transmitted genital ulcer disease. We infected domestic swine with H. ducreyi 35000, resulting in the development of cutaneous ulcers histologically resembling human chancroid lesions. Intraepidermal lesions progressed from pustules to ulcers containing polymorphonuclear leukocytes and were accompanied by a dermal inflammatory infiltrate containing T cells and macrophages. H. ducreyi was recovered from lesions up to 17 days after inoculation, and pigs did not develop immunity to reinfection with the challenge strain. Features of the model include inoculation through abrasions in the epidermis, ambient housing temperatures for infected pigs, the ability to deliver multiple different inocula to a single host, and the availability of monoclonal antibodies against porcine immune cells permitting immunohistochemical characterization of the host immune response to H. ducreyi infection
Bibliography:	L73 T10 9633481 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.63.8.3094-3100.1995