Search Results - "San Millan, Alvaro"

The evolution of antibiotic resistance by MacLean, R Craig, San Millan, Alvaro

“…Clinically relevant evolution studies are needed to help fight the spread of antibiotic resistance For most of human history, bacterial pathogens have been a…”
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Fitness Costs of Plasmids: a Limit to Plasmid Transmission by San Millan, Alvaro, MacLean, R Craig

“…Plasmids mediate the horizontal transmission of genetic information between bacteria, facilitating their adaptation to multiple environmental conditions. An…”
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Interactions between horizontally acquired genes create a fitness cost in Pseudomonas aeruginosa by San Millan, Alvaro, Toll-Riera, Macarena, Qi, Qin, MacLean, R. Craig

“…Horizontal gene transfer (HGT) plays a key role in bacterial evolution, especially with respect to antibiotic resistance. Fitness costs associated with mobile…”
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Microbial Evolution: Towards Resolving the Plasmid Paradox by MacLean, R. Craig, San Millan, Alvaro

“…Plasmids play a key role in bacterial evolution by providing bacteria with new and important functions, such as antibiotic resistance. New research shows how…”
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Staphylococcal phages and pathogenicity islands drive plasmid evolution by Humphrey, Suzanne, San Millán, Álvaro, Toll-Riera, Macarena, Connolly, John, Flor-Duro, Alejandra, Chen, John, Ubeda, Carles, MacLean, R. Craig, Penadés, José R.

“…Conjugation has classically been considered the main mechanism driving plasmid transfer in nature. Yet bacteria frequently carry so-called non-transmissible…”
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Cooperation, competition and antibiotic resistance in bacterial colonies by Frost, Isabel, Smith, William P. J., Mitri, Sara, Millan, Alvaro San, Davit, Yohan, Osborne, James M., Pitt-Francis, Joe M., MacLean, R. Craig, Foster, Kevin R.

“…Bacteria commonly live in dense and genetically diverse communities associated with surfaces. In these communities, competition for resources and space is…”
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Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context by San Millan, Alvaro

“…Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically ill patients. The…”
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β-lactamase expression induces collateral sensitivity in Escherichia coli by Herencias, Cristina, Álvaro-Llorente, Laura, Ramiro-Martínez, Paula, Fernández-Calvet, Ariadna, Muñoz-Cazalla, Ada, DelaFuente, Javier, Graf, Fabrice E., Jaraba-Soto, Laura, Castillo-Polo, Juan Antonio, Cantón, Rafael, San Millán, Álvaro, Rodríguez-Beltrán, Jerónimo

“…Major antibiotic groups are losing effectiveness due to the uncontrollable spread of antimicrobial resistance (AMR) genes. Among these, β-lactam resistance…”
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The Genomic Basis of Evolutionary Innovation in Pseudomonas aeruginosa by Toll-Riera, Macarena, San Millan, Alvaro, Wagner, Andreas, MacLean, R Craig

“…Novel traits play a key role in evolution, but their origins remain poorly understood. Here we address this problem by using experimental evolution to study…”
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Small-plasmid-mediated antibiotic resistance is enhanced by increases in plasmid copy number and bacterial fitness by San Millan, Alvaro, Santos-Lopez, Alfonso, Ortega-Huedo, Rafael, Bernabe-Balas, Cristina, Kennedy, Sean P, Gonzalez-Zorn, Bruno

“…Plasmids play a key role in the horizontal spread of antibiotic resistance determinants among bacterial pathogens. When an antibiotic resistance plasmid…”
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PCR-Based Analysis of ColE1 Plasmids in Clinical Isolates and Metagenomic Samples Reveals Their Importance as Gene Capture Platforms by Ares-Arroyo, Manuel, Bernabe-Balas, Cristina, Santos-Lopez, Alfonso, Baquero, Maria R, Prasad, Kashi N, Cid, Dolores, Martin-Espada, Carmen, San Millan, Alvaro, Gonzalez-Zorn, Bruno

“…ColE1 plasmids are important vehicles for the spread of antibiotic resistance in the Enterobacteriaceae and Pasteurellaceae families of bacteria. Their…”
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Multiresistance in Pasteurella multocida Is Mediated by Coexistence of Small Plasmids by MILLAN, Alvaro San, ESCUDERO, Jose Antonio, GUTIERREZ, Belen, HIDALGO, Laura, GARCIA, Nerea, LLAGOSTERA, Montserrat, DOMINGUEZ, Lucas, GONZALEZ-ZORN, Bruno

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Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation by Rodriguez-Beltran, Jeronimo, Hernandez-Beltran, J. Carlos R., DelaFuente, Javier, Escudero, Jose A., Fuentes-Hernandez, Ayari, MacLean, R. Craig, Peña-Miller, Rafael, San Millan, Alvaro

“…Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes,…”
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Fitness Cost and Interference of Arm/Rmt Aminoglycoside Resistance with the RsmF Housekeeping Methyltransferases by Gutierrez, Belen, Escudero, Jose A, San Millan, Alvaro, Hidalgo, Laura, Carrilero, Laura, Ovejero, Cristina M, Santos-Lopez, Alfonso, Thomas-Lopez, Daniel, Gonzalez-Zorn, Bruno

“…Arm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that confer high-level resistance to 4,6-disubstituted aminoglycosides…”
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Fluoroquinolone Efflux in Streptococcus suis Is Mediated by SatAB and Not by SmrA by Escudero, Jose Antonio, San Millan, Alvaro, Gutierrez, Belen, Hidalgo, Laura, La Ragione, Roberto M, AbuOun, Manal, Galimand, Marc, Ferrándiz, María José, Domínguez, Lucas, de la Campa, Adela G, Gonzalez-Zorn, Bruno

“…Streptococcus suis is an emerging zoonotic pathogen. With the lack of an effective vaccine, antibiotics remain the main tool to fight infections caused by this…”
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Haemophilus influenzae Clinical Isolates with Plasmid pB1000 Bearing blaROB-1: Fitness Cost and Interspecies Dissemination by SAN MILLAN, Alvaro, GARCIA-COBOS, Silvia, ESCUDERO, Jose Antonio, HIDALGO, Laura, GUTIERREZ, Belen, CARRILERO, Laura, CAMPOS, Jose, GONZALEZ-ZORN, Bruno

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ArmA Methyltransferase in a Monophasic Salmonella enterica Isolate from Food by Granier, Sophie A, Hidalgo, Laura, San Millan, Alvaro, Escudero, Jose Antonio, Gutierrez, Belen, Brisabois, Anne, Gonzalez-Zorn, Bruno

“…The 16S rRNA methyltransferase ArmA is a worldwide emerging determinant that confers high-level resistance to most clinically relevant aminoglycosides. We…”
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Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities by Alonso-del Valle, Aida, León-Sampedro, Ricardo, Rodríguez-Beltrán, Jerónimo, DelaFuente, Javier, Hernández-García, Marta, Ruiz-Garbajosa, Patricia, Cantón, Rafael, Peña-Miller, Rafael, San Millán, Alvaro

“…Plasmid persistence in bacterial populations is strongly influenced by the fitness effects associated with plasmid carriage. However, plasmid fitness effects…”
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SatR Is a Repressor of Fluoroquinolone Efflux Pump SatAB by ESCUDERO, Jose Antonio, SAN MILLAN, Alvaro, MONTERO, Natalia, GUTIERREZ, Beien, OVEJERO, Cristina Martinez, CARRILERO, Laura, GONZALEZ-ZORN, Bruno

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VanB-Type Enterococcus faecium Clinical Isolate Successively Inducibly Resistant to, Dependent on, and Constitutively Resistant to Vancomycin by SAN MILLAN, Alvaro, DEPARDIEU, Florence, GODREUIL, Sylvain, COURVALIN, Patrice

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