Search Results - "Samykutty, Abhilash"

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression by Teng, Yun, Ren, Yi, Hu, Xin, Mu, Jingyao, Samykutty, Abhilash, Zhuang, Xiaoying, Deng, Zhongbin, Kumar, Anil, Zhang, Lifeng, Merchant, Michael L., Yan, Jun, Miller, Donald M., Zhang, Huang-Ge

“…Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the…”
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Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase by Deng, Zhongbin, Rong, Yuan, Teng, Yun, Mu, Jingyao, Zhuang, Xiaoying, Tseng, Michael, Samykutty, Abhilash, Zhang, Lifeng, Yan, Jun, Miller, Donald, Suttles, Jill, Zhang, Huang-Ge

“…The intestinal immune system is continuously exposed to massive amounts of nanoparticles derived from food. Whether nanoparticles from plants we eat daily have…”
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Active Targeting Significantly Outperforms Nanoparticle Size in Facilitating Tumor-Specific Uptake in Orthotopic Pancreatic Cancer by MacCuaig, William M, Fouts, Benjamin L, McNally, Molly W, Grizzle, William E, Chuong, Phillip, Samykutty, Abhilash, Mukherjee, Priyabrata, Li, Min, Jasinski, Jacek B, Behkam, Bahareh, McNally, Lacey R

“…Nanoparticles are widely studied as theranostic vehicles for cancer; however, clinical translation has been limited due to poor tumor specificity. Features…”
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Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells by Samykutty, Abhilash, Shetty, Aditya Vittal, Dakshinamoorthy, Gajalakshmi, Bartik, Mary Margaret, Johnson, Gary Leon, Webb, Brian, Zheng, Guoxing, Chen, Aoshuang, Kalyanasundaram, Ramaswamy, Munirathinam, Gnanasekar

“…Prostate cancer is the most common solid malignancy in men, with 32,000 deaths annually. Piperine, a major alkaloid constituent of black pepper, has previously…”
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Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery by MacCuaig, William M, Samykutty, Abhilash, Foote, Jeremy, Luo, Wenyi, Filatenkov, Alexander, Li, Min, Houchen, Courtney, Grizzle, William E, McNally, Lacey R

“…Nanoparticles are popular tools utilized to selectively deliver drugs and contrast agents for identification and treatment of disease. To determine the…”
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Cathepsin B Degradable Star-Shaped Peptidic Macromolecules for Delivery of 2‑Methoxyestradiol by Shankar, Ravi, Samykutty, Abhilash, Riggin, Corinne, Kannan, Sneha, Wenzel, Ursula, Kolhatkar, Rohit

“…2-Methoxyestradiol (2ME), a natural metabolite of estradiol, has antiproliferative and antiangiogenic activity. However, its clinical success is limited due to…”
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In vivo tracking of orally-administered particles within the gastrointestinal tract of murine models using multispectral optoacoustic tomography by Bhutiani, Neal, Samykutty, Abhilash, McMasters, Kelly M., Egilmez, Nejat K., McNally, Lacey R.

“…While particle carriers have potential to revolutionize disease treatment, using these carriers requires knowledge of spatial and temporal biodistribution. The…”
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Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages by Teng, Yun, Mu, Jingyao, Hu, Xin, Samykutty, Abhilash, Zhuang, Xiaoying, Deng, Zhongbin, Zhang, Lifeng, Cao, Pengxiao, Yan, Jun, Miller, Donald, Zhang, Huang-Ge

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Applying dynamic contrast enhanced MSOT imaging to intratumoral pharmacokinetic modeling by Xiao, Ted G., Weis, Jared A., Gayzik, F. Scott, Thomas, Alexandra, Chiba, Akiko, Gurcan, Metin N., Topaloglu, Umit, Samykutty, Abhilash, McNally, Lacey R.

“…Examining the dynamics of an agent in the tumor microenvironment can offer critical insights to the influx rate and accumulation of the agent. Intratumoral…”
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Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells by Samykutty, Abhilash, Shetty, Aditya V., Dakshinamoorthy, Gajalakshmi, Kalyanasundaram, Ramaswamy, Zheng, Guoxing, Chen, Aoshuang, Bosland, Maarten C., Kajdacsy-Balla, André, Munirathinam, Gnanasekar

“…In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells. The antitumor effects of VK2 in…”
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Biochemical characterization and evaluation of a Brugia malayi small heat shock protein as a vaccine against lymphatic filariasis by Dakshinamoorthy, Gajalakshmi, Samykutty, Abhilash Kumble, Munirathinam, Gnanasekar, Shinde, Gangadhar Bhaurao, Nutman, Thomas, Reddy, Maryada Venkatarami, Kalyanasundaram, Ramaswamy

“…Filarial nematodes enjoy one of the longest life spans of any human pathogen due to effective immune evasion strategies developed by the parasite. Among the…”
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Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development by Singh, Davinder, Dheer, Divya, Samykutty, Abhilash, Shankar, Ravi

“…The antibody-drug conjugates (ADCs) are one the fastest growing biotherapeutics in oncology and are still in their infancy in gastrointestinal (GI) cancer for…”
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Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression by Zhuang, Xiaoying, Teng, Yun, Samykutty, Abhilash, Mu, Jingyao, Deng, Zhongbin, Zhang, Lifeng, Cao, Pengxiao, Rong, Yuan, Yan, Jun, Miller, Donald, Zhang, Huang-Ge

“…The lack of access to the brain is a major obstacle for central nervous system drug development. In this study, we demonstrate the capability of a…”
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Abstract 2790: Evaluation of S100A9 targeted nanoparticles containing rapamycin to treat pancreatic adenocarcinoma by Thomas, Karl, McNally, Molly, Samykutty, Abhilash, McNally, Lacey R.

“…Abstract Despite Pancreatic cancer being expected to contribute to only 3% of new cancer cases in both males and females in 2019, it is expected to cause an…”
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Abstract 1934: Development of spectrally distinct silica coated gold nanorods for detection of cancer using MSOT by Thomas, Karl N., Samykutty, Abhilash, McNally, Molly, McNally, Lacey R.

“…Abstract Traditional cancer imaging devices are limited in their ability to screen for multiple contrast agents simultaneously in real time. Multispectral…”
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Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis by Deng, Z, Rong, Y, Teng, Y, Zhuang, X, Samykutty, A, Mu, J, Zhang, L, Cao, P, Yan, J, Miller, D, Zhang, H-G

“…Acquired resistance to chemotherapy remains a major stumbling block in cancer treatment. Chronic inflammation has a crucial role in induction of…”
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Abstract 4103: Utility of multispectral optoacoustic tomography in imaging pancreatic tumors using a uPA-probe by Chiba, Akiko, Samykutty, Abhilash, Smith, Mary, McNally, Lacey

“…Abstract Background: Pancreatic cancer has the lowest 5-year survival rate of all cancer types. Current methods of pancreatic cancer screening, diagnosis and…”
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Abstract P1-01-04: Uptake of trastuzumab targeted mesoporous silica-coated chitosan capped gold nanorods in breast cancer cell lines and ex vivo patient samples by Chiba, Akiko, Thomas, Alexandra, Thomas, Karl N., Samykutty, Abhilash, McNally, Molly, McNally, Lacey

“…Abstract Background: Approximately two-thirds of operative breast cancer cases are suitable for breast conserving surgery (BCS). In order for BCS to be…”
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Abstract P3-06-04: Tumor specific cargo release in ex vivo patient samples and murine models of triple negative breast cancer by a pH-targeted nanoparticle: V3-RUBY by Thomas, Alexandra, Chiba, Akiko, Samykutty, Abhilash, McNally, Molly W., McNally, Lacey R.

“…Abstract Background: Triple negative breast cancer (TNBC), unlike other breast cancer subtypes, lacks a specific targetable receptor. As such tumor specific…”
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Abstract 1954: Tracking of orally-administered particles within the gastrointestinal tract of murine models using multispectral optoacoustic tomography by Bhutiani, Neal, Samykutty, Abhilash, McMasters, Kelly, Egilmez, Nejat, McNally, Lacey R.

“…Abstract While particle carriers have potential to revolutionize disease treatment, using these carriers requires knowledge of spatial and temporal…”
Get full text