Search Results - "Samuels, L"

Droplet microfluidic technology for single-cell high-throughput screening by Brouzes, Eric, Medkova, Martina, Savenelli, Neal, Marran, Dave, Twardowski, Mariusz, Hutchison, J. Brian, Rothberg, Jonathan M, Link, Darren R, Perrimon, Norbert, Samuels, Michael L

“…We present a droplet-based microfluidic technology that enables high-throughput screening of single mammalian cells. This integrated platform allows for the…”
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The GFDL Global Ocean and Sea Ice Model OM4.0: Model Description and Simulation Features by Adcroft, Alistair, Anderson, Whit, Balaji, V., Blanton, Chris, Bushuk, Mitchell, Dufour, Carolina O., Dunne, John P., Griffies, Stephen M., Hallberg, Robert, Harrison, Matthew J., Held, Isaac M., Jansen, Malte F., John, Jasmin G., Krasting, John P., Langenhorst, Amy R., Legg, Sonya, Liang, Zhi, McHugh, Colleen, Radhakrishnan, Aparna, Reichl, Brandon G., Rosati, Tony, Samuels, Bonita L., Shao, Andrew, Stouffer, Ronald, Winton, Michael, Wittenberg, Andrew T., Xiang, Baoqiang, Zadeh, Niki, Zhang, Rong

“…We document the configuration and emergent simulation features from the Geophysical Fluid Dynamics Laboratory (GFDL) OM4.0 ocean/sea ice model. OM4 serves as…”
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Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity by Baret, Jean-Christophe, Miller, Oliver J, Taly, Valerie, Ryckelynck, Michaël, El-Harrak, Abdeslam, Frenz, Lucas, Rick, Christian, Samuels, Michael L, Hutchison, J Brian, Agresti, Jeremy J, Link, Darren R, Weitz, David A, Griffiths, Andrew D

“…We describe a highly efficient microfluidic fluorescence-activated droplet sorter (FADS) combining many of the advantages of microtitre-plate screening and…”
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The Protease Inhibitor Amprenavir Protects against Pepsin-Induced Esophageal Epithelial Barrier Disruption and Cancer-Associated Changes by Blaine-Sauer, Simon, Samuels, Tina L, Yan, Ke, Johnston, Nikki

“…Gastroesophageal reflux disease (GERD) significantly impacts patient quality of life and is a major risk factor for the development of Barrett's esophagus (BE)…”
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GFDL’s ESM2 Global Coupled Climate–Carbon Earth System Models. Part I: Physical Formulation and Baseline Simulation Characteristics by Dunne, John P., John, Jasmin G., Adcroft, Alistair J., Griffies, Stephen M., Hallberg, Robert W., Shevliakova, Elena, Stouffer, Ronald J., Cooke, William, Dunne, Krista A., Harrison, Matthew J., Krasting, John P., Malyshev, Sergey L., Milly, P. C. D., Phillipps, Peter J., Sentman, Lori T., Samuels, Bonita L., Spelman, Michael J., Winton, Michael, Wittenberg, Andrew T., Zadeh, Niki

“…The physical climate formulation and simulation characteristics of two new global coupled carbon–climate Earth System Models, ESM2M and ESM2G, are described…”
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The South African universal preschool year: a case study of policy development and implementation by Richter, L., Samuels, M.‐L.

“…Background South Africa is the first sub‐Saharan African country to legislate, fund and implement free preschool education. Human rights and restitution were…”
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Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation by Abdel-Mohsen, Mohamed, Chavez, Leonard, Tandon, Ravi, Chew, Glen M, Deng, Xutao, Danesh, Ali, Keating, Sheila, Lanteri, Marion, Samuels, Michael L, Hoh, Rebecca, Sacha, Jonah B, Norris, Philip J, Niki, Toshiro, Shikuma, Cecilia M, Hirashima, Mitsuomi, Deeks, Steven G, Ndhlovu, Lishomwa C, Pillai, Satish K

“…Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent…”
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Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease by Ergun, Pelin, Samuels, Tina L, Mathison, Angela J, Plehhova, Kate, Coyle, Cathal, Horvath, Lizzie, Johnston, Nikki

“…Breakthrough symptoms are thought to occur in roughly half of all gastroesophageal reflux disease (GERD) patients despite maximal acid suppression (proton pump…”
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High-resolution dose—response screening using droplet-based microfluidics by Miller, Oliver J., Harrak, Abdeslam El, Mangeat, Thomas, Baret, Jean-Christophe, Frenz, Lucas, Debs, Bachir El, Mayot, Estelle, Samuels, Michael L., Rooney, Eamonn K., Dieu, Pierre, Galvan, Martin, Link, Darren R., Griffiths, Andrew D.

“…A critical early step in drug discovery is the screening of a chemical library. Typically, promising compounds are identified in a primary screen and then more…”
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The GFDL CM3 Coupled Climate Model: Characteristics of the Ocean and Sea Ice Simulations by Griffies, Stephen M., Winton, Michael, Donner, Leo J., Horowitz, Larry W., Downes, Stephanie M., Farneti, Riccardo, Gnanadesikan, Anand, Hurlin, William J., Lee, Hyun-Chul, Liang, Zhi, Palter, Jaime B., Samuels, Bonita L., Wittenberg, Andrew T., Wyman, Bruce L., Yin, Jianjun, Zadeh, Niki

“…This paper documents time mean simulation characteristics from the ocean and sea ice components in a new coupled climate model developed at the NOAA…”
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Topical Alginate Protection against Pepsin-Mediated Esophageal Damage: E-Cadherin Proteolysis and Matrix Metalloproteinase Induction by Samuels, Tina L, Blaine-Sauer, Simon, Yan, Ke, Plehhova, Kate, Coyle, Cathal, Johnston, Nikki

“…Epithelial barrier dysfunction is a hallmark of gastroesophageal reflux disease (GERD) related to symptom origination, inflammatory remodeling and…”
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Efficacy and Safety of Trabectedin in Patients With Advanced or Metastatic Liposarcoma or Leiomyosarcoma After Failure of Prior Anthracyclines and Ifosfamide: Results of a Randomized Phase II Study of Two Different Schedules by DEMETRI, George D, CHAWLA, Sant P, LEBEDINSKY, Claudia, ELSAYED, Yusri A, IZQUIERDO, Miguel A, GOMEZ, Javier, PARK, Youn C, LE CESNE, Axel, VON MEHREN, Margaret, RITCH, Paul, BAKER, Laurence H, BLAY, Jean Y, HANDE, Kenneth R, KEOHAN, Mary L, SAMUELS, Brian L, SCHUETZE, Scott

“…To evaluate the safety and efficacy of trabectedin in a phase II, open-label, multicenter, randomized study in adult patients with unresectable/metastatic…”
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BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles by Chen, Walter W, Balaj, Leonora, Liau, Linda M, Samuels, Michael L, Kotsopoulos, Steve K, Maguire, Casey A, LoGuidice, Lori, Soto, Horacio, Garrett, Matthew, Zhu, Lin Dan, Sivaraman, Sarada, Chen, Clark, Wong, Eric T, Carter, Bob S, Hochberg, Fred H, Breakefield, Xandra O, Skog, Johan

“…Development of biofluid-based molecular diagnostic tests for cancer is an important step towards tumor characterization and real-time monitoring in a minimally…”
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Efficacy of Imatinib in Aggressive Fibromatosis: Results of a Phase II Multicenter Sarcoma Alliance for Research through Collaboration (SARC) Trial by CHUGH, Rashmi, WATHEN, J. Kyle, BENJAMIN, Robert S, BAKER, Laurence H, PATEL, Shreyaskumar R, MAKI, Robert G, MEYERS, Paul A, SCHUETZE, Scott M, PRIEBAT, Dennis A, THOMAS, Dafydd G, JACOBSON, Jon A, SAMUELS, Brian L

“…Aggressive fibromatoses (AF; desmoid tumors) are rare clonal neoplastic proliferations of connective tissues that can be locally aggressive despite wide…”
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Detection and Analysis of Low-Abundance Cell-Surface Biomarkers Using Enzymatic Amplification in Microfluidic Droplets by Joensson, Haakan N, Samuels, Michael L, Brouzes, Eric R, Medkova, Martina, Uhlén, Mathias, Link, Darren R, Andersson-Svahn, Helene

“…Finding the few: Cell-surface proteins are useful disease biomarkers, but current high-throughput methods are limited to detecting cells expressing more than…”
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Clinical outcomes and safety with trabectedin therapy in patients with advanced soft tissue sarcomas following failure of prior chemotherapy: results of a worldwide expanded access program study by Samuels, B.L., Chawla, S., Patel, S., von Mehren, M., Hamm, J., Kaiser, P.E., Schuetze, S., Li, J., Aymes, A., Demetri, G.D.

“…This expanded access program (EAP) was designed to provide trabectedin access for patients with incurable soft tissue sarcoma (STS) following progression of…”
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Emerging technologies in extracellular vesicle-based molecular diagnostics by Jia, Shidong, Zocco, Davide, Samuels, Michael L, Chou, Michael F, Chammas, Roger, Skog, Johan, Zarovni, Natasa, Momen-Heravi, Fatemeh, Kuo, Winston Patrick

“…Extracellular vesicles (EVs), including exosomes and microvesicles, have been shown to carry a variety of biomacromolecules including mRNA, microRNA and other…”
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Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types by Onuchic, Vitor, Hartmaier, Ryan J., Boone, David N., Samuels, Michael L., Patel, Ronak Y., White, Wendy M., Garovic, Vesna D., Oesterreich, Steffi, Roth, Matt E., Lee, Adrian V., Milosavljevic, Aleksandar

“…Cancer progression depends on both cell-intrinsic processes and interactions between different cell types. However, large-scale assessment of cell type…”
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Visualization of cellulose synthases in Arabidopsis secondary cell walls by Watanabe, Y., Meents, M. J., McDonnell, L. M., Barkwill, S., Sampathkumar, A., Cartwright, H. N., Demura, T., Ehrhardt, D. W., Samuels, A. L., Mansfield, S. D.

“…Cellulose biosynthesis in plant secondary cell walls forms the basis of vascular development in land plants, with xylem tissues constituting the vast majority…”
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ABC transporters coordinately expressed during lignification of Arabidopsis stems include a set of ABCBs associated with auxin transport by Kaneda, M., Schuetz, M., Lin, B.S.P., Chanis, C., Hamberger, B., Western, T.L., Ehlting, J., Samuels, A.L.

“…The primary inflorescence stem of Arabidopsis thaliana is rich in lignified cell walls, in both vascular bundles and interfascicular fibres. Previous gene…”
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