Search Results - "Samuels, Brian"

Acute effects of posture on intraocular pressure by Nelson, Emily S, Myers, Jr, Jerry G, Lewandowski, Beth E, Ethier, C Ross, Samuels, Brian C

“…Many experiments have documented the response of intraocular pressure (IOP) to postural change. External forces caused by gravitational orientation change…”
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Biomechanical changes of tree shrew posterior sclera during experimental myopia, after retrobulbar vehicle injections, and crosslinking using genipin by Bianco, Gianfranco, Girkin, Christopher A., Samuels, Brian C., Fazio, Massimo A., Grytz, Rafael

“…Myopia is a common ocular condition characterized by biomechanical weakening revealed by increasing creep rate, cyclic softening scleral thinning, change of…”
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The Impact of Choroidal Swelling on Optic Nerve Head Deformation by Feola, Andrew J, Nelson, Emily S, Myers, Jerry, Ethier, C Ross, Samuels, Brian C

“…Choroid geometry and swelling have been proposed to contribute to ocular pathologies. Thus, it is important to understand how the choroid may impact the optic…”
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Comparative Cost-effectiveness of Trabeculectomy versus MicroShunt in the US Medicare System by Atik, Alp, Fahy, Eamonn T, Rhodes, Lindsay A, Samuels, Brian C, Mennemeyer, Stephen T, Girkin, Christopher A

“…To assess the societal cost-utility of the MicroShunt compared with trabeculectomy for the surgical management of glaucoma in the US Medicare system…”
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Association of Long-Duration Spaceflight With Anterior and Posterior Ocular Structure Changes in Astronauts and Their Recovery by Macias, Brandon R, Patel, Nimesh B, Gibson, C Robert, Samuels, Brian C, Laurie, Steven S, Otto, Christian, Ferguson, Connor R, Lee, Stuart M C, Ploutz-Snyder, Robert, Kramer, Larry A, Mader, Thomas H, Brunstetter, Tyson, Stenger, Michael B

“…During long-duration spaceflights, nearly all astronauts exhibit some change in ocular structure within the spectrum of spaceflight-associated neuro-ocular…”
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Finite Element Modeling of Factors Influencing Optic Nerve Head Deformation Due to Intracranial Pressure by Feola, Andrew J, Myers, Jerry G, Raykin, Julia, Mulugeta, Lealem, Nelson, Emily S, Samuels, Brian C, Ethier, C Ross

“…Visual impairment and intracranial pressure (VIIP) syndrome is a health concern for long-duration spaceflight, and a proposed risk factor is elevation of…”
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Prevalence of Subretinal Drusenoid Deposits in Older Persons with and without Age-Related Macular Degeneration, by Multimodal Imaging by Zarubina, Anna V., MD, Neely, David C., MD, Clark, Mark E., BS, Huisingh, Carrie E., MPH, Samuels, Brian C., MD, PhD, Zhang, Yuhua, PhD, McGwin, Gerald, MS, PhD, Owsley, Cynthia, PhD, MSPH, Curcio, Christine A., PhD

“…Purpose To assess the prevalence of subretinal drusenoid deposits (SDD) in older adults with healthy maculas and early and intermediate age-related macular…”
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Efficacy and Safety of Trabectedin in Patients With Advanced or Metastatic Liposarcoma or Leiomyosarcoma After Failure of Prior Anthracyclines and Ifosfamide: Results of a Randomized Phase II Study of Two Different Schedules by DEMETRI, George D, CHAWLA, Sant P, LEBEDINSKY, Claudia, ELSAYED, Yusri A, IZQUIERDO, Miguel A, GOMEZ, Javier, PARK, Youn C, LE CESNE, Axel, VON MEHREN, Margaret, RITCH, Paul, BAKER, Laurence H, BLAY, Jean Y, HANDE, Kenneth R, KEOHAN, Mary L, SAMUELS, Brian L, SCHUETZE, Scott

“…To evaluate the safety and efficacy of trabectedin in a phase II, open-label, multicenter, randomized study in adult patients with unresectable/metastatic…”
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Diurnal Cycle of Translaminar Pressure in Nonhuman Primates Quantified With Continuous Wireless Telemetry by Jasien, Jessica V, Samuels, Brian C, Johnston, James M, Downs, J Crawford

“…Recent retrospective clinical studies and animal experiments have suggested that cerebrospinal fluid pressure (CSFP) is important in glaucoma pathogenesis…”
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A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy by Feola, Andrew J, Girkin, Christopher A, Ethier, C Ross, Samuels, Brian C

“…Nonarteritic anterior ischemic optic neuropathy (NAION) has been associated with a thickened choroid at the optic nerve head (ONH). Here, we use computational…”
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Results of a prospective phase 2 study of pazopanib in patients with advanced intermediate‐grade or high‐grade liposarcoma by Samuels, Brian L., Chawla, Sant P., Somaiah, Neeta, Staddon, Arthur P., Skubitz, Keith M., Milhem, Mohammed M., Kaiser, Pamela E., Portnoy, David C., Priebat, Dennis A., Walker, Mark S., Stepanski, Edward J.

“…BACKGROUND This phase 2, single‐arm, multicenter study was designed to determine the treatment activity and safety of single‐agent pazopanib in patients with…”
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Effect of Body Position on Intraocular Pressure (IOP), Intracranial Pressure (ICP), and Translaminar Pressure (TLP) Via Continuous Wireless Telemetry in Nonhuman Primates (NHPs) by Jasien, Jessica V, Samuels, Brian C, Johnston, James M, Downs, J Crawford

“…Recent retrospective clinical studies and animal experiments have suggested that cerebrospinal fluid pressure (CSFP) is important in glaucoma, acting through…”
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Dual Orexin Receptor Antagonist Attenuates Increases in IOP, ICP, and Translaminar Pressure Difference After Stimulation of the Hypothalamus in Rats by DeCarlo, Arthur A, Hammes, Nathan, Johnson, Philip L, Shekhar, Anantha, Samuels, Brian C

“…Intraocular pressure (IOP) remains the only modifiable risk factor for glaucoma progression. Our previous discovery that stimulation of nuclei within the…”
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A Novel Tree Shrew (Tupaia belangeri) Model of Glaucoma by Samuels, Brian C, Siegwart, John T, Zhan, Wenjie, Hethcox, Lisa, Chimento, Melissa, Whitley, Ryan, Downs, J Crawford, Girkin, Christopher A

“…Primates and rodents are used widely as animal models of glaucoma, but each has significant limitations. Researchers need additional animal models that closely…”
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The Magnitude and Time Course of IOP Change in Response to Body Position Change in Nonhuman Primates Measured Using Continuous IOP Telemetry by Turner, Daniel C, Samuels, Brian C, Huisingh, Carrie, Girkin, Christopher A, Downs, J Crawford

“…To study the effect and time course of body position changes on IOP in nonhuman primates. We recorded continuous bilateral IOP measurements with a wireless…”
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Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia by KhalafAllah, Mahmoud T, Fuchs, Preston A, Nugen, Fred, El Hamdaoui, Mustapha, Levy, Alexander, Redden, David T, Samuels, Brian C, Grytz, Rafael

“…To investigate the relative positional changes between the Bruch's membrane opening (BMO) and the anterior scleral canal opening (ASCO), and border tissue…”
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Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews by KhalafAllah, Mahmoud T., Fuchs, Preston A., Nugen, Fred, El Hamdaoui, Mustapha, Levy, Alexander M., Samuels, Brian C., Grytz, Rafael

“…Myopia is an independent risk factor for glaucoma, but the link between both conditions remains unknown. Both conditions induce connective tissue remodeling at…”
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Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor by Schuetze, Scott M., Bolejack, Vanessa, Choy, Edwin, Ganjoo, Kristen N., Staddon, Arthur P., Chow, Warren A., Tawbi, Hussein A., Samuels, Brian L., Patel, Shreyaskumar R., Mehren, Margaret, D'Amato, Gina, Leu, Kirsten M., Loeb, David M., Forscher, Charles A., Milhem, Mohammed M., Rushing, Daniel A., Lucas, David R., Chugh, Rashmi, Reinke, Denise K., Baker, Laurence H.

“…BACKGROUND Alveolar soft part sarcoma (ASPS), chondrosarcoma (CS), chordoma, epithelioid sarcoma, and solitary fibrous tumor (SFT) are malignant tumors that…”
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Efficacy of Imatinib in Aggressive Fibromatosis: Results of a Phase II Multicenter Sarcoma Alliance for Research through Collaboration (SARC) Trial by CHUGH, Rashmi, WATHEN, J. Kyle, BENJAMIN, Robert S, BAKER, Laurence H, PATEL, Shreyaskumar R, MAKI, Robert G, MEYERS, Paul A, SCHUETZE, Scott M, PRIEBAT, Dennis A, THOMAS, Dafydd G, JACOBSON, Jon A, SAMUELS, Brian L

“…Aggressive fibromatoses (AF; desmoid tumors) are rare clonal neoplastic proliferations of connective tissues that can be locally aggressive despite wide…”
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Detection and characterization of tree shrew retinal venous pulsations: An animal model to study human retinal venous pulsations by Dattilo, Michael, Read, A. Thomas, Samuels, Brian C., Ethier, C. Ross

“…Spontaneous retinal venous pulsations (SRVPs), pulsations of branches of the central retinal vein, are affected by intraocular pressure (IOP) and intracranial…”
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