Search Results - "Samuel, Stephen P"

Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes by Lewin, Matthew R, Carter, Rebecca W, Matteo, Isabel A, Samuel, Stephen P, Rao, Sunita, Fry, Bryan G, Bickler, Philip E

“…The availability of effective, reliably accessible, and affordable treatments for snakebite envenoming is a critical and long unmet medical need. Recently,…”
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Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom by Lewin, Matthew R, Gilliam, Lyndi L, Gilliam, John, Samuel, Stephen P, Bulfone, Tommaso C, Bickler, Philip E, Gutiérrez, José María

“…There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be given rapidly after the time of…”
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Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite by Lewin, Matthew R., Bickler, Philip E., Samuel, Stephen P., Bulfone, Tommaso C.

“…The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of…”
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The BRAVO Clinical Study Protocol: Oral Varespladib for Inhibition of Secretory Phospholipase A2 in the Treatment of Snakebite Envenoming by Carter, Rebecca W, Gerardo, Charles J, Samuel, Stephen P, Kumar, Surendra, Kotehal, Suneetha D, Mukherjee, Partha P, Shirazi, Farshad M, Akpunonu, Peter D, Bammigatti, Chanaveerappa, Bhalla, Ashish, Manikath, Neeraj, Platts-Mills, Timothy F, Lewin, Matthew R

“…Snakebite is an urgent, unmet global medical need causing significant morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory…”
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Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom by Lewin, Matthew R, Gutiérrez, José María, Samuel, Stephen P, Herrera, María, Bryan-Quirós, Wendy, Lomonte, Bruno, Bickler, Philip E, Bulfone, Tommaso C, Williams, David J

“…There is an unmet need for economical snakebite therapies with long shelf lives that are effective even with delays in treatment. The orally bioavailable,…”
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Some concerns on 'clinico-epidemiological profile and outcome of snakebite patients presented to a teaching institute - A descriptive retrospective review' by Mohanty, Chitta R, Barik, Amiya K, Radhakrishnan, Rakesh V, Samuel, Stephen P

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Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan Oxyuranus scutellatus Venoms by Gilliam, Lyndi L, Gilliam, John, Samuel, Stephen P, Carter, Rebecca W, Ritchey, Jerry, Bulfone, Tommaso, Gutiérrez, José María, Williams, David J, Durkin, Daniela M, Stephens, Sally I, Lewin, Matthew R

“…Antivenom is currently the standard-of-care treatment for snakebite envenoming, but its efficacy is limited by treatment delays, availability, and in many…”
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State-of-the-art review - A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis? by Kalita, Bhargab, Saviola, Anthony J., Samuel, Stephen P., Mukherjee, Ashis K.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent responsible for the Coronavirus Disease-2019 (COVID-19) pandemic, has…”
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In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib by Chowdhury, Abhinandan, Fry, Bryan G., Samuel, Stephen P., Bhalla, Ashish, Vaiyapuri, Sakthi, Bhargava, Parul, Carter, Rebecca W., Lewin, Matthew R.

“…Bungarus (krait) envenomings are well-known for their life-threatening neurotoxic effects. However, their impact on coagulation remains largely unexplored…”
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Early Treatment with Intranasal Neostigmine Reduces Mortality in a Mouse Model of ＂Naja Naja＂ (Indian Cobra) Envenomation by Vaiyapuri, Sakthivel, Bickler, Philip, Wexler, David S., Samuel, Stephen P., Lewin, Matthew R., Mensh, Brett D.

“…Objective. Most snakebite deaths occur prior to hospital arrival; yet inexpensive, effective, and easy to administer out-of-hospital treatments do not exist…”
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Snakebite: An Exploratory Cost-Effectiveness Analysis of Adjunct Treatment Strategies by Herzel, Benjamin J, Samuel, Stephen P, Bulfone, Tommaso C, Raj, C Soundara, Lewin, Matthew, Kahn, James G

“…The cost-effectiveness of the standard of care for snakebite treatment, antivenom, and supportive care has been established in various settings. In this study,…”
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CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility by Samuel, Stephen P, Santos-Martinez, Maria J, Medina, Carlos, Jain, Namrata, Radomski, Marek W, Prina-Mello, Adriele, Volkov, Yuri

“…New nanomaterials intended for systemic administration have raised concerns regarding their biocompatibility and hemocompatibility. Quantum dots (QD)…”
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Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial by Gerardo, Charles J, Carter, Rebecca W, Kumar, Surendra, Shirazi, Farshad M, Kotehal, Suneetha D, Akpunonu, Peter D, Bhalla, Ashish, Schwartz, Richard B, Bammigatti, Chanaveerappa, Manikath, Neeraj, Mukherjee, Partha P, Arnold, Thomas C, Wolk, Brian J, S Sheikh, Sophia, Sollee, Dawn R, Vearrier, David J, Francis, Samuel J, Aizenberg, Adiel, Kumar, Harish, Ravikumar, Madhu K, Sarkar, Sujoy, Haston, Taylor, Micciche, Andrew, Oomman, Suraj C, Owen, Jeffery L, Ritter, Brandi A, Samuel, Stephen P, Lewin, Matthew R, Platts-Mills, Timothy F

“…Snakebite envenoming (SBE) results in over 500 000 deaths or disabling injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2,…”
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Parotid swelling after Russell's viper envenomation: an unusual and poor prognostic sign by Sasidaran, Maanoj N., Samuel, Stephen P., ChinnaRaju, Soundararaj, Antonysamy, Michael, Bulfone, Tommaso C., Lewin, Matthew R.

“…Key Clinical Message Parotid swelling, an unusual and poorly understood sign, is associated with poor prognosis in the setting of Russell's viper envenomation…”
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Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan IOxyuranus scutellatus/I Venoms by Gilliam, Lyndi L, Gilliam, John, Samuel, Stephen P, Carter, Rebecca W, Ritchey, Jerry, Bulfone, Tommaso, Gutiérrez, José María, Williams, David J, Durkin, Daniela M, Stephens, Sally I, Lewin, Matthew R

“…Antivenom is currently the standard-of-care treatment for snakebite envenoming, but its efficacy is limited by treatment delays, availability, and in many…”
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Early treatment with intranasal neostigmine reduces mortality in a mouse model of Naja naja by Lewin, Matthew R, Wexler, David S, Vaiyapuri, Sakthivel, Bickler, Philip, Mensh, Brett D, Samuel, Stephen P

“…Objective. Most snakebite deaths occur prior to hospital arrival; yet inexpensive, effective, and easy to administer out-of-hospital treatments do not exist…”
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Parotid swelling after Russell's viper envenomation: an unusual and poor prognostic sign by Sasidaran, Maanoj N, Samuel, Stephen P, ChinnaRaju, Soundararaj, Antonysamy, Michael, Bulfone, Tommaso C, Lewin, Matthew R

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