Search Results - "Samudrala, Gourinath"

The actin cytoskeleton orchestra in Entamoeba histolytica by Rath, Pragyan Parimita, Gourinath, Samudrala

“…Years of evolution have kept actin conserved throughout various clades of life. It is an essential protein starring in many cellular processes. In a primitive…”
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Functional implications of residues of the B′ motif of geminivirus replication initiator protein in its helicase activity by Ruhel, Rajrani, Mazumder, Mohit, Gnanasekaran, Prabu, Kumar, Manish, Gourinath, Samudrala, Chakraborty, Supriya

“…Geminivirus replication initiator protein (Rep) is a multifunctional viral protein required for replication. During the process of viral replication, Rep acts…”
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Calcium‐binding protein EhCaBP3 is recruited to the phagocytic complex of Entamoeba histolytica by interacting with Arp2/3 complex subunit 2 by Babuta, Mrigya, Kumar, Sanjeev, Gourinath, Samudrala, Bhattacharya, Sudha, Bhattacharya, Alok

“…Phagocytosis is involved in invasive disease of the parasite Entamoeba histolytica. Upon binding of red blood cells, there is a sequential recruitment of…”
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Deep Insight into the Phosphatomes of Parasitic Protozoa and a Web Resource ProtozPhosDB by Anwar, Tamanna, Gourinath, Samudrala

“…Phosphorylation dynamically regulates the function of proteins by maintaining a balance between protein kinase and phosphatase activity. A comprehensive…”
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Redox homeostasis in Mycobacterium tuberculosis is modulated by a novel actinomycete‐specific transcription factor by Khan, Mehak Zahoor, Singha, Biplab, Ali, Mohammad Farhan, Taunk, Khushman, Rapole, Srikanth, Gourinath, Samudrala, Nandicoori, Vinay Kumar

“…Mycobacterium tuberculosis ( Mtb ) has evolved diverse cellular processes in response to the multiple stresses it encounters within the infected host. We…”
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Virtual screening, identification and in vitro testing of novel inhibitors of O-acetyl-L-serine sulfhydrylase of Entamoeba histolytica by Nagpal, Isha, Raj, Isha, Subbarao, Naidu, Gourinath, Samudrala

“…The explosive epidemicity of amoebiasis caused by the facultative gastrointestinal protozoan parasite Entamoeba histolytica is a major public health problem in…”
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Structure-based mutational studies of O -acetylserine sulfhydrylase reveal the reason for the loss of cysteine synthase complex formation in Brucella abortus by Dharavath, Sudhaker, Raj, Isha, Gourinath, Samudrala

“…Cysteine biosynthesis takes place via a two-step pathway in bacteria, fungi, plants and protozoan parasites, but not in humans, and hence, the machinery of…”
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Structure-Based Design of Inhibitors of the Crucial Cysteine Biosynthetic Pathway Enzyme O-Acetyl Serine Sulfhydrylase by Mazumder, Mohit, Gourinath, Samudrala

“…The cysteine biosynthetic pathway is of fundamental importance for the growth, survival, and pathogenicity of the many pathogens. This pathway is present in…”
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EhFP10: A FYVE family GEF interacts with myosin IB to regulate cytoskeletal dynamics during endocytosis in Entamoeba histolytica by Gautam, Gunjan, Ali, Mohammad Sabir, Bhattacharya, Alok, Gourinath, Samudrala

“…Motility and phagocytosis are key processes that are involved in invasive amoebiasis disease caused by intestinal parasite Entamoeba histolytica. Previous…”
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Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations by Singh, Rohit Kumar, Kumar, Devbrat, Gourinath, Samudrala

“…Serine is ubiquitously synthesized in all living organisms from the glycolysis intermediate 3-phosphoglycerate (PGA) by phosphoserine biosynthetic pathway,…”
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Cdc42/Rac Interactive Binding Containing Effector Proteins in Unicellular Protozoans With Reference to Human Host: Locks of the Rho Signaling by Umarao, Preeti, Rath, Pragyan Parimita, Gourinath, Samudrala

“…Small GTPases are the key to actin cytoskeleton signaling, which opens the lock of effector proteins to forward the signal downstream in several cellular…”
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Role of kinases in virulence and pathogenesis of protozoan parasite E. Histolytica by Ahmad, Azhar, Mishra, Shalini, Som Lata, Gourinath, Samudrala

“…Protein kinases are known to regulate several cellular processes like metabolism, motility and endocytosis through phosphorylation of specific target proteins…”
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Accelerated identification of serine racemase inhibitor from Centella asiatica by Rani, Komal, Tyagi, Mitali, Mazumder, Mohit, Singh, Akanksha, Shanmugam, Annaian, Dalal, Krishna, Pillai, Manoj, Samudrala, Gourinath, Kumar, Saroj, Srinivasan, Alagiri

“…Serine racemase (SR) converts the free form of L-serine into D-serine (DS) in the mammalian brain. The DS functions as a co-agonist of N-methyl D-aspartate…”
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Identification and characterization of Helicobacter pylori O‐acetylserine‐dependent cystathionine β‐synthase, a distinct member of the PLP‐II family by Devi, Suneeta, Tarique, Khaja Faisal, Ali, Mohammad Farhan, Abdul Rehman, Syed Arif, Gourinath, Samudrala

“…Summary O‐acetylserine sulfhydrylase (OASS) and cystathionine β‐synthase (CBS) are members of the PLP‐II family, and involved in L‐cysteine production. OASS…”
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Structural characterization and functional analysis of cystathionine β‐synthase: an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis by Devi, Suneeta, Abdul Rehman, Syed A., Tarique, Khaja F., Gourinath, Samudrala

“…The reverse transsulfuration pathway has been reported to produce cysteine from homocysteine in eukaryotes ranging from protozoans to mammals while bacteria…”
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SDS can be utilized as an amyloid inducer: a case study on diverse proteins by Khan, Javed Masood, Qadeer, Atiyatul, Chaturvedi, Sumit Kumar, Ahmad, Ejaz, Rehman, Syed Arif Abdul, Gourinath, Samudrala, Khan, Rizwan Hasan

“…Sodium dodecyl sulphate (SDS), an anionic surfactant that mimics some characteristics of biological membrane has also been found to induce aggregation in…”
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Analysis of the Protein phosphotome of Entamoeba histolytica reveals an intricate phosphorylation network by Anwar, Tamanna, Gourinath, Samudrala

“…Phosphorylation is the most common mechanism for the propagation of intracellular signals. Protein phosphatases and protein kinases play a dynamic antagonistic…”
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EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica by Agarwal, Shalini, Anand, Gaurav, Sharma, Shalini, Parimita Rath, Pragyan, Gourinath, Samudrala, Bhattacharya, Alok

“…The highly conserved proteins of the 14-3-3 family are universal adaptors known to regulate an enormous range of cellular processes in eukaryotes. However,…”
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Identification of Small Molecule Inhibitors Targeting Phosphoserine Phosphatase: A Novel Target for the Development of Antiamoebic Drugs by Kumari, Poonam, Agrawal, Prakhar, Umarao, Preeti, Ramachandran, Vijayan, Gourinath, Samudrala

“…Amoebiasis, a widespread disease caused by the protozoan parasite Entamoeba histolytica, poses challenges due to the adverse effects of existing antiamoebic…”
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Structure-based inhibitor screening of natural products against NSP15 of SARS-CoV-2 revealed thymopentin and oleuropein as potent inhibitors by Vijayan, Ramachandran, Gourinath, Samudrala

“…Coronaviruses are enveloped, non-segmented positive-sense RNA viruses with the largest genome among RNA viruses. Their genome contains a large replicase ORF…”
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