Search Results - "Samudio, Ismael J"

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML by Zeng, Zhihong, Xi Shi, Yue, Samudio, Ismael J., Wang, Rui-Yu, Ling, Xiaoyang, Frolova, Olga, Levis, Mark, Rubin, Joshua B., Negrin, Robert R., Estey, Elihu H., Konoplev, Sergej, Andreeff, Michael, Konopleva, Marina

“…SDF-1α/CXCR4 signaling plays a key role in leukemia/bone marrow microenvironment interactions. We previously reported that bone marrow–derived stromal cells…”
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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML by Zeng, Zhihong, Sarbassov, Dos D., Samudio, Ismael J., Yee, Karen W.L., Munsell, Mark F., Ellen Jackson, C., Giles, Francis J., Sabatini, David M., Andreeff, Michael, Konopleva, Marina

“…The mTOR complex 2 (mTORC2) containing mTOR and rictor is thought to be rapamycin insensitive and was recently shown to regulate the prosurvival kinase AKT by…”
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Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias by Zeng, Zhihong, Samudio, Ismael J, Munsell, Mark, An, Jing, Huang, Ziwei, Estey, Elihu, Andreeff, Michael, Konopleva, Marina

“…The chemokine receptor CXCR4 mediates the migration of hematopoietic cells to the stroma-derived factor 1α (SDF-1α)–producing bone marrow microenvironment…”
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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy by Kojima, Kensuke, Konopleva, Marina, Samudio, Ismael J., Shikami, Masato, Cabreira-Hansen, Maria, McQueen, Teresa, Ruvolo, Vivian, Tsao, Twee, Zeng, Zhihong, Vassilev, Lyubomir T., Andreeff, Michael

“…Although TP53 mutations are rare in acute myeloid leukemia (AML), inactivation of wild-type p53 protein frequently occurs through overexpression of its…”
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Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel by Giraldo, Carlos E, López, Catalina, Álvarez, María E, Samudio, Ismael J, Prades, Marta, Carmona, Jorge U

“…There is no information on the effects of the breed, gender and age on the cellular content and growth factor (GF) release from equine pure-platelet rich…”
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Concomitant Inhibition of MDM2 and Bcl-2 Protein Function Synergistically Induce Mitochondrial Apoptosis in AML by Kojima, Kensuke, Konopleva, Marina, Samudio, Ismael J, Schober, Wendy D, Bornmann, William, Andreeff, Michael

“…Disruption of Mdm2-p53 interaction activates p53 signaling, disrupts the balance ofantiapoptotic and proapoptotic Bcl-2 family proteins and induces apoptosis…”
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Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells by KOJIMA, Kensuke, KONOPLEVA, Marina, SAMUDIO, Ismael J, RUVOLO, Vivian, ANDREEFF, Michael

“…Activation of the Raf/MEK/ERK pathway and inactivation of wild-type p53 by Mdm2 overexpression are frequent molecular events in acute myelogenous leukemia…”
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Simultaneous inhibition of PDK1/AKT and fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia by ZHIHONG ZENG, SAMUDIO, Ismael J, PENG HUANG, YILING LU, MILLS, Gordon B, ANDREEFF, Michael, KONOPLEVA, Marina, WEIGUO ZHANG, ESTROV, Zeev, PELICANO, Hélène, HARRIS, David, FROLOVA, Olga, HAIL, Numsen, WENJING CHEN, KORNBLAU, Steven M

“…Phosphoinositol-3-kinase (PI3K)/protein kinase B (AKT) and Fms-like tyrosine kinase 3 (FLT3) signaling are aberrantly activated in acute myelogenous leukemia…”
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Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide by Ríos, Diana L, López, Catalina, Álvarez, María E, Samudio, Ismael J, Carmona, Jorge U

“…Platelet-rich plasma (PRP) preparations are a common treatment in osteoarthritis (OA) and inflammatory synovitis. However, there is ambiguity regarding the…”
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A novel ring-substituted diindolylmethane, 1,1-bis[3'-(5-Methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia by CONTRACTOR, Rooha, SAMUDIO, Ismael J, ESTROV, Zeev, HARRIS, David, MCCUBREY, James A, SAFE, Stephen H, ANDREEFF, Michael, KONOPLEVA, Marina

“…We investigated the antileukemic activity and molecular mechanisms of action of a newly synthesized ring-substituted diindolylmethane derivative,…”
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Autologous Platelet Concentrates as an Adjunctive Treatment for Chronic Laminitis in a Mare with Pituitary Pars Intermedia Dysfunction by Carmona, Jorge U., López, Catalina, Samudio, Ismael J.

“…The aim of this article was to describe a case of a 7-year-old mare with chronic laminitis secondary to pituitary pars intermedia dysfunction that was…”
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Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells by Samudio, Ismael J., Duvvuri, Seshagiri, Clise-Dwyer, Karen, Watt, Julie C., Mak, Duncan, Kantarjian, Hagop, Yang, Dajun, Ruvolo, Vivian, Borthakur, Gautam

“…Non-mutational inactivation of p53 is frequent in acute myeloid leukemia (AML) via overexpression of MDM2. We report that treatment with MI-63, a novel…”
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HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML by Zhou, L, Ruvolo, V R, McQueen, T, Chen, W, Samudio, I J, Conneely, O, Konopleva, M, Andreeff, M

“…Nur77 and Nor1 are highly conserved orphan nuclear receptors. We have recently reported that nur77 −/− nor1 −/− mice rapidly develop acute myeloid leukemia…”
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Synergistic Activation of p53 Family of Proteins by the Combination of Nutlin 3a and SAHA in Acute Myelogenous Leukemia by Borthakur, Gautam, Duvvuri, Seshagiri, Samudio, Ismael J., Kojima, Kensuke, Konopleva, Marina, Andreeff, Michael

“…Abstract 1738 Poster Board I-764 Nutlin 3a binds to murine double minute 2 (MDM2) a negative regulator of p53 and potently increases p53 protein levels by…”
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Pharmacological Inhibition of Fatty Acid Oxidation as a Novel Therapeutic Concept for Acute Myeloid Leukemia by Andreeff, Michael, Fiegl, Michael, Konopleva, Marina, Korchin, Borys, Kaluarachchi, Kumar, Bornmann, William G., Guthrie, Patrick H., Harmancey, Romain, Taegtmeyer, Heinrich, Samudio, Ismael J.

“…Abstract 3779 Poster Board III-715 Otto Warburg proposed that the origin of cancer cells was closely linked to a permanent respiratory defect that bypassed the…”
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CXCR4 Expression and Biological Activity Is Dependent on Oxygen Partial Pressure in Acute Myeloid Leukemia by Fiegl, Michael, Samudio, Ismael J., Dwyer, Karen Clise, Burks, Jared, Fritsche, Herbert, Mnjoyan, Zakar H., Andreeff, Michael

“…CXCR4, the receptor for bone marrow stroma derived SDF-1, has recently been studied in normal hematopoiesis and hematologic malignancies. Increased expression…”
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Targeting Anaplerotic Pathways That Support Fatty Acid Metabolism as a Therapeutic Strategy for Hematological Malignancies: The Achilles' Heel of the Warburg Effect by Samudio, Ismael J., Fiegl, Michael, Konopleva, Marina, Kaluarachchi, Kumar, McMurray, John S., Korchin, Borys, Dwyer, Karen Clise, Harmancey, Romain, Guthrie, Patrick, Taegtmeyer, Heinrich, Andreeff, Michael

“…More than half a century ago, Otto Warburg proposed that the origin of cancer cells was closely linked to a permanent respiratory defect that bypassed the…”
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Targeting the Hypoxic Microenvironment by mTOR Inhibitors Sensitizes ALL Cells to Chemotherapy by Frolova, Olga, Samudio, Ismael J., Mnjoyan, Zakar H., Lu, Hongbo, Konoplev, Sergej, Thomas, Deborah A., Kantarjian, Hagop M., Shpall, Elizabeth J., Andreeff, Michael, Konopleva, Marina

“…The main therapeutic challenge in the treatment of Acute Lymphocytic Leukemia (ALL) is the development of strategies aimed at overcoming resistance to…”
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Apoptosis Inducing Factor Acts as a Survival Factor in Acute Myelogenous Leukemia through Mitochondrial Complex 1 by Wang, Rui-yu, Samudio, Ismael J., McQueen, Teresa, Schober, Wendy D., Ruvolo, Vivian R., Kornblau, Steven, Konopleva, Marina, Andreeff, Michael

“…Apoptosis inducing factor (AIF) is a mitochondrial flavoprotein that is released into the cytoplasm to form an active DNase and then translocates into the…”
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Activation of p53 signaling by MI-63 induces apoptosis in acute myelogenous leukemia cells by Samudio, Ismael J, Duvvuri, Seshagiri, Clise-Dwyer, Karen, Watt, Julie C, Mak, Duncan, Kantarjian, Hagop, Yang, Dajun, Ruvolo, Vivian, Borthakur, Gautam

“…Non-mutational inactivation of p53 is frequent in acute myeloid leukemia (AML) via overexpression of MDM2. We report that treatment with MI-63, a novel…”
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