Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia

Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia

Abstract Five children in Pos Lenjang, Pahang, Malaysia were PCR-positive for vivax malaria and were admitted to the hospital from 5 to 26 July 2019. One of the patients experienced three episodes of recurrence of vivax malaria. Microsatellite analysis showed that reinfection is unlikely. Drug resis...

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Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 114; no. 9; pp. 700 - 703
Main Authors: Mat Salleh, Noor Hafizan, Rahman, Mohd Faizal Abdul, Samsusah, Samsiah, De Silva, Jeremy Ryan, Ng, David Chun-Ern, Ghozali, Azilawati Hanim, Tan, Jia Hui, Lai, Meng Yee, Amir, Amirah, Liew, Jonathan Wee Kent, Lau, Yee Ling
Format: Journal Article
Language:English
Published: England Oxford University Press 01-09-2020
Subjects:
mutation
drug resistance
CYP2D6
recurrent
Plasmodium vivax
Online Access:Get full text
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Summary:Abstract Five children in Pos Lenjang, Pahang, Malaysia were PCR-positive for vivax malaria and were admitted to the hospital from 5 to 26 July 2019. One of the patients experienced three episodes of recurrence of vivax malaria. Microsatellite analysis showed that reinfection is unlikely. Drug resistance analysis indicated that Riamet (artemether–lumefantrine) is effective. Cytochrome P450 2D6 (CYP2D6) testing showed that this patient has defective CYP2D6 function. Primaquine failure to clear the Plasmodium vivax hypnozoites may be the cause of recurring infections in this patient. This report highlights the need for the development of liver-stage curative antimalarials that do not require metabolism by the CYP2D6 enzyme.
Bibliography:ObjectType-Case Study-2
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ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/traa042