A controlled double-blind study of femoxetine and amitriptyline in patients with endogenous depression

The new selective serotonin (5-HT)-uptake inhibitor femoxetine was compared with amitriptyline in a double-blind clinical trial comprising 77 depressed patients. The depressive symptoms were evaluated with the Hamilton rating scale, and a global clinical evaluation. Both drugs showed an antidepressi...

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Bibliographic Details
Published in:	Pharmacopsychiatria Vol. 15; no. 5; p. 164
Main Authors:	Reebye, P N, Yiptong, C, Samsoon, J, Schulsinger, F, Fabricius, J
Format:	Journal Article
Language:	English
Published:	Germany 01-09-1982
Subjects:	Amitriptyline - adverse effects Amitriptyline - therapeutic use Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Clinical Trials as Topic Depressive Disorder - drug therapy Double-Blind Method Female Humans Male Middle Aged Piperidines - adverse effects Piperidines - therapeutic use Psychiatric Status Rating Scales
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Summary:	The new selective serotonin (5-HT)-uptake inhibitor femoxetine was compared with amitriptyline in a double-blind clinical trial comprising 77 depressed patients. The depressive symptoms were evaluated with the Hamilton rating scale, and a global clinical evaluation. Both drugs showed an antidepressive effect and no significant differences were found. Femoxetine induced a significantly lower frequency of dry mouth and blurred vision; this difference is presumably due to the weak anticholinergic effect of this substance. A small but significant weight loss was observed in the femoxetine group but not in the amitriptyline group.
ISSN:	0720-4280
DOI:	10.1055/s-2007-1019531