Search Results - "Samson, Willis K"
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GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Published in The Journal of clinical investigation (01-05-2020)“…Treating neuropathic pain is challenging and novel non-opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses,…”
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Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-09-2016)“…Sexual maturation and maintenance of reproductive function are regulated by neurohormonal communication between the hypothalamus, pituitary, and gonads…”
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Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents
Published in Pain (Amsterdam) (01-01-2020)“…Chemotherapy-induced neuropathic pain (CINP) in both sexes compromises many current chemotherapeutics and lacks an FDA-approved therapy. We recently identified…”
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The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction
Published in Expert opinion on therapeutic targets (01-06-2008)“…The paraventricular nucleus of the hypothalamus (PVN) has emerged as one of the most important autonomic control centers in the brain, with neurons playing…”
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Neural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, corticotropin-releasing hormone, and oxytocin
Published in American journal of physiology. Regulatory, integrative and comparative physiology (15-05-2014)“…Nesfatin-1 is produced in the periphery and in the brain where it has been demonstrated to regulate appetite, stress hormone secretion, and cardiovascular…”
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Permeability of the blood–brain barrier to a novel satiety molecule nesfatin-1
Published in Peptides (New York, N.Y. : 1980) (01-12-2007)“…Nesfatin-1 has recently been identified as a hypothalamic and brain stem peptide that regulates feeding behavior. Here, we determined the ability of nesfatin-1…”
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Nesfatin-1 inhibits NPY neurons in the arcuate nucleus
Published in Brain research (16-09-2008)“…Abstract Although the novel satiety factor nesfatin-1 has been shown to influence feeding behavior through effects on melanocortin signaling, the specific…”
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GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia
Published in Nutrients (11-05-2023)“…The g-protein coupled receptor GPR-160, recently identified as a putative receptor for the cocaine and amphetamine-regulated transcript (CART) peptide, shows…”
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The phoenixins: From discovery of the hormone to identification of the receptor and potential physiologic actions
Published in Peptides (New York, N.Y. : 1980) (01-08-2018)“…•Phoenixin is a recently described peptide hormone that is produced by the brain and heart.•Phoenixin exerts its cellular activities via interaction with the G…”
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The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function
Published in Frontiers in neuroendocrinology (01-07-2003)“…The hypocretins/orexins are hypothalamic peptides most recognized for their significant effects on feeding and arousal. Indeed, loss of the peptides results in…”
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Cardiovascular and antidipsogenic effects of nesfatin-1
Published in Current pharmaceutical design (01-12-2013)“…Nesfatin-1, derived from the nucleobindin-2 gene product, is expressed in neurons located in brain centers known to be important in the central regulation of…”
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Adrenomedullin and the control of fluid and electrolyte homeostasis
Published in Annual review of physiology (01-01-1999)“…Two potent hypotensive peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP), are encoded by the adrenomedullin gene. AM stimulates…”
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Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions
Published in The Journal of biological chemistry (14-11-2008)“…Somatostatin is important in the regulation of diverse neuroendocrine functions. Based on bioinformatic analyses of evolutionarily conserved sequences, we…”
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Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-04-2005)“…Intermedin (IMD)/adrenomedullin-2 (AM2) is a novel peptide that was independently discovered by two groups. The 47-amino acid peptide is homologous to…”
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The 2019 New Investigator Review Awards
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-02-2019)Get more information
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The 2018 New Investigator Review Awards
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-03-2018)Get more information
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A possible relationship between brain-derived adrenomedullin and oxytocin in the regulation of sodium balance
Published in Journal of endocrinology (01-11-2009)“…Exaggerated thirst and salt appetite occurs when endogenous, brain-derived adrenomedullin (AM) production is compromised. In addition, the arginine vasopressin…”
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A primer on obesity-related cardiomyopathy
Published in Physiological reviews (01-01-2022)Get full text
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