Search Results - "Samson, Maria Elena S"

Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers by Sun, Kaiming, Atoyan, Ruzanna, Borek, Mylissa A, Dellarocca, Steven, Samson, Maria Elena S, Ma, Anna W, Xu, Guang-Xin, Patterson, Troy, Tuck, David P, Viner, Jaye L, Fattaey, Ali, Wang, Jing

“…Upregulation of MYC is a common driver event in human cancers, and some tumors depend on MYC to maintain transcriptional programs that promote cell growth and…”
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Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells by Beier, Kevin T., Samson, Maria Elena S., Matsuda, Takahiko, Cepko, Constance L.

“…An understanding of the number and types of progeny produced by progenitor cells during development provides a foundation for studies of when and where cell…”
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Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion by Wang, Jing, Pursell, Natalie W, Samson, Maria Elena S, Atoyan, Ruzanna, Ma, Anna W, Selmi, Abdelkader, Xu, Wanlu, Cai, Xiong, Voi, Maurizio, Savagner, Pierre, Lai, Cheng-Jung

“…CUDC-101 is a novel, small-molecule, anticancer agent targeting histone deacetylase (HDAC), EGF receptor (EGFR), and HER2. It is currently in phase I clinical…”
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Production and Design of More Effective Avian Replication-Incompetent Retroviral Vectors by Chen, C.-M.Amy, Smith, Devyn M., Peters, Maureen A., Samson, Maria Elena S., Zitz, Julie, Tabin, Clifford J., Cepko, Constance L.

“…Retroviral vectors have been invaluable tools for studies of development in vertebrates. Their use has been somewhat constrained, however, by the low viral…”
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Combination of IRAK4 Inhibitor CA-4948 with BCL2 Inhibitor Venetoclax Induces Tumor Regression in an ABC-DLBCL Xenograft Model by Booher, Robert, Dellarocca, Steven, Atoyan, Ruzanna, Borek, Mylissa, Samson, Maria Elena S., Tuck, David

“…IRAK4 kinase activity is required for toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling in a variety of myeloid and lymphoid cell types…”
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Preclinical Activity of IRAK4 Kinase Inhibitor CA-4948 Alone or in Combination with Targeted Therapies and Preliminary Phase 1 Clinical Results in Non-Hodgkin Lymphoma by Booher, Robert N, Nowakowski, Grzegorz S., Patel, Krish, Lunning, Matthew A., Samson, Maria Elena S., Atoyan, Ruzanna, Ma, Anna W, Xu, Guang-Xin, Dellarocca, Steven, Modafferi, Holly, Borek, Mylissa, Zhang, Zhidong, Parker, Jefferson, Whitney, Duncan, Wang, Hongwei, Tuck, David P, Younes, Anas

“…Background: IRAK4 kinase activity is required for toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling in a variety of myeloid and lymphoid…”
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Abstract 127: Efficacy of novel IRAK4 inhibitor CA4948 in AML and MDS by Choudhary, Gaurav S., Bhagat, Tushar D., Samson, Maria Elena S., Gordon, Shanisha, Ahrens, Dagny Von, Pradhan, Kith, Shastri, Aditi, Pellagatti, Andrea, Boutlwood, Jacqueline, Booher, Robert N., Steidl, Ulrich, Verma, Amit

“…Abstract Myelodysplastic syndrome (MDS) & Acute Myeloid Leukemia (AML) are hematologic malignancies that arise from a population of aberrant hematopoietic stem…”
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Abstract 917: Post-treatment changes in levels of TNF family ligands and XIAP may predict sensitivity to IAP antagonist CUDC-427 by Atoyan, Ruzanna, Samson, Maria Elena S., Hantzis, Brianne, Ma, Anna W., Yin, Ling, Borek, Mylissa, Dellarocca, Steven, Zifcak, Brian, Xu, Guangxin, Wang, Jing

“…Abstract Inhibitors of apoptosis (IAP) proteins are a novel target for cancer therapy. Antagonists of IAP proteins have been shown to synergize with TNF…”
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Abstract 1879: Dual function HDAC and PI3K inhibitor, CUDC-907 affects cancer cells and the tumor microenvironment in hematological malignancies by Ma, Anna W., Atoyan, Ruzanna, Younes, Anas, Flinn, Ian W., Oki, Yasuhiro, Copeland, Amanda, Berdeja, Jesus G., Laliberte, Robert, Viner, Jaye, Samson, Maria Elena S., Dellarocca, Steven, Yi, Ling, Borek, Mylissa, Zifcak, Brian, Xu, Guangxin, Wang, Jing

“…Abstract Histone deacetylases (HDACs) and the phosphatidylinositol 3-kinase (PI3K)/AKT pathway are promising therapeutic targets in hematologic cancers and…”
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