Search Results - "Samson, Mani"
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Identification of novel dysregulated circular RNAs in early‐stage breast cancer
Published in Journal of cellular and molecular medicine (01-04-2021)“…Breast cancer is a major cause of cancer‐related death in women worldwide. Non‐coding RNAs are a potential resource to be used as an early diagnostic biomarker…”
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Role of Circulating Cell-Free DNA in Cancers
Published in Molecular diagnosis & therapy (01-12-2015)“…Liquid biopsy is a term used to describe non-invasive tests, which provide information about disease conditions through analysis of circulating cell-free DNA…”
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Identification of lncRNAs associated with early‐stage breast cancer and their prognostic implications
Published in Molecular oncology (01-06-2019)“…Breast cancer is the most common malignancy among women, with the highest incidence rate worldwide. Dysregulation of long noncoding RNAs during the preliminary…”
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Alteration of miR-362-5p and miR-454-3p expression elicits diverse responses in breast cancer cell lines
Published in Molecular biology reports (2022)“…Background The heterogeneity of breast tumors presents a challenge in disease management, necessitating an understanding of the molecular mechanisms driving…”
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Targeting the NF-κB p65/Bcl-2 signaling pathway in hepatic cellular carcinoma using radiation assisted synthesis of zinc nanoparticles coated with naturally isolated gallic acid
Published in Biomedicine & pharmacotherapy (01-03-2024)“…Oral diethylnitrosamine (DEN) is a known hepatocarcinogen that damages the liver and causes cancer. DEN damages the liver through reactive oxygen…”
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Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway
Published in Frontiers in immunology (15-04-2024)“…Skin injuries represent a prevalent form of physical trauma, necessitating effective therapeutic strategies to expedite the wound healing process. Hesperidin,…”
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Experimental and Computational Approaches for Non-CpG Methylation Analysis
Published in Epigenomes (16-08-2022)“…Cytosine methylation adjacent to adenine, thymine, and cytosine residues but not guanine of the DNA is distinctively known as non-CpG methylation. This…”
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MicroRNA Expression Profile in Early-Stage Breast Cancers
Published in MicroRNA (Shariqah, United Arab Emirates) (01-01-2024)“…Breast cancer is one of the leading causes of cancer deaths in women. Early diagnosis offers the best hope for a cure. Ductal carcinoma in situ is considered a…”
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Identification of lnc RNA s associated with early‐stage breast cancer and their prognostic implications
Published in Molecular oncology (01-06-2019)“…Breast cancer is the most common malignancy among women, with the highest incidence rate worldwide. Dysregulation of long noncoding RNA s during the…”
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Locus-Specific Enrichment Analysis of 5-Hydroxymethylcytosine Reveals Novel Genes Associated with Breast Carcinogenesis
Published in Cells (Basel, Switzerland) (20-09-2022)“…An imbalance in DNA methylation is a hallmark epigenetic alteration in cancer. The conversion of 5-methylcytosine (5-mC) to 5-hydroxymethyl cytosine (5-hmC),…”
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Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma
Published in Tumor biology (01-04-2012)“…The Wnt pathway is a key regulator of embryonic development and stem cells, and its aberrant activation is associated with human malignancies, most notably…”
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Experience with the Use of Nilotinib in Indian Patients
Published in Indian journal of hematology & blood transfusion (01-07-2018)“…Important genetic and ethnic factors could affect the toxicity and efficacy of tyrosine kinase inhibitors. Though nilotinib has been available in India since…”
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Regulation and Functional Significance of 5-Hydroxymethylcytosine in Cancer
Published in Epigenomes (01-12-2017)“…Epigenetic modes of gene regulation are important for physiological conditions and its aberrant changes can lead to disease like cancer…”
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Comprehensive analysis of long non-coding RNAs in early stage breast cancer
Published in Canadian Journal of Biotechnology (01-10-2017)“…Abstract only…”
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DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract
Published in Epigenetics (01-03-2012)“…Cancers of the upper aerodigestive tract (UADT) are common forms of malignancy associated with tobacco and alcohol exposures, although human papillomavirus and…”
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Perspectives of long non-coding RNAs in cancer
Published in Molecular biology reports (01-04-2017)“…A recent advance in transcriptomics has spawned the ‘Decade of non-coding RNAs’ by potentiating the growing numbers of long non-coding RNA in cancer. LncRNA…”
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DNA Demethylating Agents and Epigenetic Therapy of Cancer
Published in Advances in Genetics (2010)“…Epigenetic events have been associated with virtually every step of tumor development and progression, and epigenetic alterations are believed to occur early…”
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Book Chapter Journal Article -
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Non-CpG methylation—a key epigenetic modification in cancer
Published in Briefings in functional genomics (11-09-2021)“…The methylation of cytosine residues that precede adenine/thymine or other cytosine nucleotides instead of guanine in DNA is known as non-CpG methylation. It…”
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The lncRNA MIAT is regulated by NFYA to promote glioblastoma multiforme through the miR-221-3p/SIRT1 axis
Published in Gene reports (01-03-2024)“…Glioblastoma multiforme (GBM) is an aggressive form of brain tumor that accounts for 47.7 % of all brain and central nervous system (CNS) tumor types with poor…”
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Copy Number Gains of DNA Repair Genes Along with TP53 Deletion May Result in Poor Response to Treatment in Newly Diagnosed Multiple Myeloma
Published in Transplantation and cellular therapy (01-02-2024)“…Risk stratification in multiple myeloma is done by cytogenetics and interphase FISH. Recently, a process named ‘Chromothripsis”, literally meaning “shattering…”
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