Search Results - "Samra, Elias Bou"

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS by Gratia, Matthieu, Rodero, Mathieu P, Conrad, Cécile, Bou Samra, Elias, Maurin, Mathieu, Rice, Gillian I, Duffy, Darragh, Revy, Patrick, Petit, Florence, Dale, Russell C, Crow, Yanick J, Amor-Gueret, Mounira, Manel, Nicolas

“…Cellular innate immune sensors of DNA are essential for host defense against invading pathogens. However, the presence of self-DNA inside cells poses a risk of…”
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A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival by Bou Samra, Elias, Buhagiar-Labarchède, Géraldine, Machon, Christelle, Guitton, Jérôme, Onclercq-Delic, Rosine, Green, Michael R., Alibert, Olivier, Gazin, Claude, Veaute, Xavier, Amor-Guéret, Mounira

“…Cells from Bloom’s syndrome patients display genome instability due to a defective BLM and the downregulation of cytidine deaminase. Here, we use a genome-wide…”
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A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD by Silveira, Sandra Cunha, Buhagiar-Labarchède, Géraldine, Onclercq-Delic, Rosine, Gemble, Simon, Bou Samra, Elias, Mameri, Hamza, Duchambon, Patricia, Machon, Christelle, Guitton, Jérôme, Amor-Guéret, Mounira

“…Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from CDA…”
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Identification of a 20-Gene Expression-Based Risk Score as a Predictor of Clinical Outcome in Chronic Lymphocytic Leukemia Patients by Bou Samra, Elias, Klein, Bernard, Commes, Thérèse, Moreaux, Jérôme

“…Despite the improvement in treatment options, chronic lymphocytic leukemia (CLL) remains an incurable disease and patients show a heterogeneous clinical course…”
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New chimeric RNAs in acute myeloid leukemia [version 2; peer review: 2 approved] by Rufflé, Florence, Audoux, Jerome, Boureux, Anthony, Beaumeunier, Sacha, Gaillard, Jean-Baptiste, Bou Samra, Elias, Megarbane, Andre, Cassinat, Bruno, Chomienne, Christine, Alves, Ronnie, Riquier, Sebastien, Gilbert, Nicolas, Lemaitre, Jean-Marc, Bacq-Daian, Delphine, Bougé, Anne Laure, Philippe, Nicolas, Commes, Therese

“…Background: High-throughput next generation sequencing (NGS) technologies enable the detection of biomarkers used for tumor classification, disease monitoring…”
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Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients by Bou Samra, Elias, Klein, Bernard, Commes, Thérèse, Moreaux, Jérôme

“…Patients with normal karyotype represent the single largest cytogenetic group of acute myeloid leukemia (AML), with highly heterogeneous clinical and molecular…”
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New prognostic markers, determined using gene expression analyses, reveal two distinct subtypes of chronic myelomonocytic leukaemia patients by Bou Samra, Elias, Moreaux, Jérôme, Vacheret, Fabienne, Mills, Ken, Rufflé, Florence, Chiesa, Jean, Piquemal, David, Boureux, Anthony, Lavabre-Bertrand, Thierry, Jourdan, Eric, Commes, Thérèse

“…Summary Chronic myelomonocytic leukaemia (CMML) is a heterogeneous haematopoietic disorder characterized by myeloproliferative or myelodysplastic features. At…”
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Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks by Samra, Elias Bou, Mahé, Yann Franck, Le Balch, Mickael, Cavusoglu, Nükhet, Bouhanna, Pierre, Bakkar, Khalid

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Age-associated thin hair displays molecular, structural and mechanical characteristic changes by Baltenneck, Frédéric, Genty, Gaianne, Samra, Elias Bou, Richena, Marina, Harland, Duane P., Clerens, Stefan, Leccia, Emilie, Le Balch, Mickael, Doucet, Jean, Michelet, Jean-François, Commo, Stéphane

“…[Display omitted] •Age-associated thin hairs exhibit imbalanced hair keratins and KAPs expressions and changes in cortex organization.•In hair thinning, hair…”
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A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD by Silveira, Sandra Cunha, Buhagiar-Labarchède, Géraldine, Onclercq-Delic, Rosine, Gemble, Simon, Bou Samra, Elias, Mameri, Hamza, Duchambon, Patricia, Machon, Christelle, Guitton, Jérôme, Amor-Guéret, Mounira

“…Abstract Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from…”
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Combining DGE and RNA-sequencing data to identify new polyA+ non-coding transcripts in the human genome by Philippe, Nicolas, Bou Samra, Elias, Boureux, Anthony, Mancheron, Alban, Rufflé, Florence, Bai, Qiang, De Vos, John, Rivals, Eric, Commes, Thérèse

“…Recent sequencing technologies that allow massive parallel production of short reads are the method of choice for transcriptome analysis. Particularly, digital…”
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New prognostic markers, determined using gene expression analyses, reveal two distinct subtypes of chronic myelomonocytic leukaemia patients: Molecular prognostic markers in CMML by Bou Samra, Elias, Moreaux, Jérôme, Vacheret, Fabienne, Mills, Ken, Rufflé, Florence, Chiesa, Jean, Piquemal, David, Boureux, Anthony, Lavabre-Bertrand, Thierry, Jourdan, Eric, Commes, Thérèse

“…Chronic myelomonocytic leukaemia (CMML) is a heterogeneous haematopoietic disorder characterized by myeloproliferative or myelodysplastic features. At present,…”
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New chimeric RNAs in acute myeloid leukemia [version 1; peer review: 1 approved, 1 approved with reservations] by Rufflé, Florence, Audoux, Jerome, Boureux, Anthony, Beaumeunier, Sacha, Gaillard, Jean-Baptiste, Bou Samra, Elias, Megarbane, Andre, Cassinat, Bruno, Chomienne, Christine, Alves, Ronnie, Riquier, Sebastien, Gilbert, Nicolas, Lemaitre, Jean-Marc, Bacq-Daian, Delphine, Bougé, Anne Laure, Philippe, Nicolas, Commes, Therese

“…Background: High-throughput next generation sequencing (NGS) technologies enable the detection of biomarkers used for tumor classification, disease monitoring…”
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