Search Results - "Sampson, S. N."

Clodronate improves lameness in horses without changing bone turnover markers by Mitchell, A., Wright, G., Sampson, S. N., Martin, M., Cummings, K., Gaddy, D., Watts, A. E.

“…Summary Background Clodronate is prescribed to performance horses with lameness. Despite its clinical popularity, little research has been done to understand…”
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Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase by Kursula, I., Salin, M., Sun, J., Norledge, B.V., Haapalainen, A.M., Sampson, N.S., Wierenga, R.K.

“…The conformational switch from open to closed of the flexible loop 6 of triosephosphate isomerase (TIM) is essential for the catalytic properties of TIM. Using…”
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Standardised exercise testing in 17 reining horses: Musculoskeletal, respiratory, cardiac and clinicopathological findings by Navas de Solis, C., Sampson, S. N., McKay, T., Whitfield‐Cargile, C.

“…Summary Exercise testing can be useful to evaluate poor performance, as a preventative medicine tool, and in the assessment of training progression. A…”
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The Presence of a Hydrogen Bond between Asparagine 485 and the π System of FAD Modulates the Redox Potential in the Reaction Catalyzed by Cholesterol Oxidase by Yin, Ye, Sampson, Nicole S, Vrielink, Alice, Lario, Paula I

“…Cholesterol oxidase catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. An asparagine residue (Asn485) at the active site is…”
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Dissection of a flavoenzyme active site: the reaction catalyzed by cholesterol oxidase by Sampson, N S

“…Cholesterol oxidase is a member of the glucose-methanol-choline (GMC) oxidoreductase family that is characterized by a conserved topology. We review our…”
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The equine cervical spine: comparing MRI and contrast-enhanced CT images with anatomic slices in the sagittal, dorsal, and transverse plane by Sleutjens, J., Cooley, A.J., Sampson, S.N., Wijnberg, I.D., Back, W., van der Kolk, J.H., Swiderski, C.E.

“…Background: The impact of cervical pathology on performance is of great importance to the horse industry. Accurate diagnosis of cervical disease with imaging…”
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Use of the Parallax-Quench Method to Determine the Position of the Active-Site Loop of Cholesterol Oxidase in Lipid Bilayers by Chen, Xiaoyu, Wolfgang, David E, Sampson, Nicole S

“…To elucidate the cholesterol oxidase−membrane bilayer interaction, a cysteine was introduced into the active site lid at position-81 using the Brevibacterium…”
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Segmental motion in catalysis: investigation of a hydrogen bond critical for loop closure in the reaction of triosephosphate isomerase by Sampson, Nicole S, Knowles, Jeremy R

“…A residue essential for proper closure of the active-site loop in the reaction catalyzed by triosephosphate isomerase is tyrosine-208, the hydroxyl group of…”
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Determination of the amino acid requirements for a protein hinge in triosephosphate isomerase by Sun, Jeonghoon, Sampson, Nicole S.

“…We have determined the sequence requirements for a protein hinge in triosephosphate isomerase. The codons encoding the hinge at the C‐terminus of the…”
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Segmental movement: definition of the structural requirements for loop closure in catalysis by triosephosphate isomerase by Sampson, Nicole S, Knowles, Jeremy R

“…To determine what drives the closure of the active-site loop in the reaction catalyzed by triosephosphate isomerase, several residues involved in hydrogen…”
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Characterization of fertilinβ-disintegrin binding specificity in sperm-egg adhesion by GUPTA, S, HAISHAN LI, SAMPSON, N. S

“…An essential step leading to fertilization is the binding of a sperm to the egg plasma membrane. Fertilin beta, a membrane bound protein on the extracellular…”
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Crystal structures of .alpha.-lytic protease complexes with irreversibly bound phosphonate esters by Bone, Roger, Sampson, Nicole S, Bartlett, Paul A, Agard, David A

“…The structures of the complexes with alpha-lytic protease of both phosphorus stereoisomers of…”
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Library screening studies to investigate substrate specificity in the reaction catalyzed by cholesterol oxidase by Xiang, J., Sampson, N.S.

“…We tested whether it is possible to alter the substrate specificity of cholesterol oxidase for similarly sized sterols, i.e. cholesterol, β-sitosterol and…”
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Crystal Structure Determination of Cholesterol Oxidase from Streptomyces and Structural Characterization of Key Active Site Mutants by Yue, Q. Kimberley, Kass, Ignatius J, Sampson, Nicole S, Vrielink, Alice

“…Cholesterol oxidase is a monomeric flavoenzyme which catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. The enzyme interacts with…”
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Surface Molecular Recognition by Sampson, Nicole S., Mrksich, Milan, Bertozzi, Carolyn R.

“…The spatial display of cellular ligands and receptors is important for cell adhesion and communication. Two approaches that emphasize developing selective…”
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Understanding Protein Lids:  Kinetic Analysis of Active Hinge Mutants in Triosephosphate Isomerase by Sun, Jeonghoon, Sampson, Nicole S

“…In previous work we tested what three amino acid sequences could serve as a protein hinge in triosephosphate isomerase [Sun, J., and Sampson, N. S. (1998)…”
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The importance of hinge sequence for loop function and catalytic activity in the reaction catalyzed by triosephosphate isomerase by Xiang, J, Sun, J, Sampson, N S

“…We have determined the sequence requirements for the N-terminal protein hinge of the active-site lid of triosephosphate isomerase. The codons for the hinge…”
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Targeting Multiple Binding Sites on Cholera Toxin B with Glycomimetic Polymers Promotes the Formation of Protein–Polymer Aggregates by Youn, Gyusaang, Cervin, Jakob, Yu, Xiaoxi, Bhatia, Surita R, Yrlid, Ulf, Sampson, Nicole S

“…The canonical binding site on the B subunit of cholera toxin (CTB) binds to GM1 gangliosides on host cells. However, the recently discovered noncanonical…”
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Dimyristoylated Peptides Incorporated into Liposomes Are Polyvalent Fertilin β Mimics by Gupta, Suparna, Sampson, Nicole S

“…Fertilin β is an integral membrane sperm protein that is involved in sperm binding to the egg plasma membrane. We synthesized a dimyristoylated fertilin β…”
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Construction of a catalytically inactive cholesterol oxidase mutant: investigation of the interplay between active site-residues glutamate 361 and histidine 447 by Yin, Ye, Liu, Pingsheng, Anderson, Richard G.W, Sampson, Nicole S

“…Cholesterol oxidase catalyzes the oxidation of cholesterol to cholest-5-en-3-one and its subsequent isomerization into cholest-4-en-3-one. Two active-site…”
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