Search Results - "Sampson, K J"

Molecular Pathophysiology of Congenital Long QT Syndrome by Bohnen, M S, Peng, G, Robey, S H, Terrenoire, C, Iyer, V, Sampson, K J, Kass, R S

“…Ion channels represent the molecular entities that give rise to the cardiac action potential, the fundamental cellular electrical event in the heart. The…”
Get full text

A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome by Sampson, K. J., Iyer, V., Marks, A. R., Kass, R. S.

“…Computer modelling has emerged as a particularly useful tool in understanding the physiology and pathophysiology of cardiac tissues. Models of ventricular,…”
Get full text

Simulation and prediction of functional block in the presence of structural and ionic heterogeneity by Sampson, K J, Henriquez, C S

“…Inhomogeneities in myocardial structure and action potential duration (APD) lead to dispersion of APD throughout the heart. APD gradients in the range of…”
Get more information

F plasmid conjugative DNA transfer: the TraI helicase activity is essential for DNA strand transfer by Matson, S W, Sampson, J K, Byrd, D R

“…The product of the Escherichia coli F plasmid traI gene is required for DNA transfer via bacterial conjugation. This bifunctional protein catalyzes the…”
Get full text

Structure-Function Analysis of Escherichia coli DNA Helicase I Reveals Non-overlapping Transesterase and Helicase Domains by Byrd, Devon R, Sampson, Juliana K, Ragonese, Heather M, Matson, Steven W

“…TraI (DNA helicase I) is an Escherichia coli F plasmid-encoded protein required for bacterial conjugative DNA transfer. The protein is a sequence-specific DNA…”
Get full text

Molecular basis of ranolazine block of LQT‐3 mutant sodium channels: evidence for site of action by Fredj, Sandra, Sampson, Kevin J, Liu, Huajun, Kass, Robert S

“…1 We studied the effects of ranolazine, an antianginal agent with promise as an antiarrhythmic drug, on wild‐type (WT) and long QT syndrome variant 3 (LQT‐3)…”
Get full text

Autonomic Control of Cardiac Action Potentials: Role of Potassium Channel Kinetics in Response to Sympathetic Stimulation by Terrenoire, Cecile, Clancy, Colleen E, Cormier, Joseph W, Sampson, Kevin J, Kass, Robert S

“…IKs, the slowly activating component of the delayed rectifier current, plays a major role in repolarization of the cardiac action potential (AP). Genetic…”
Get full text

Electrotonic influences on action potential duration dispersion in small hearts: a simulation study by Sampson, Kevin J, Henriquez, Craig S

“…Intrinsic spatial variations in repolarization currents in the heart can produce spatial gradients in action potential duration (APD) that serve as possible…”
Get more information

Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an IKs transgenic mouse by Sampson, Kevin J., Terrenoire, Cecile, Cervantes, Daniel O., Kaba, Riyaz A., Peters, Nicholas S., Kass, Robert S.

“…Inherited gain-of-function mutations of genes coding for subunits of the heart slow potassium (I Ks ) channel can cause familial atrial fibrillation (AF). Here…”
Get full text

A resistor interpretation of general anisotropic cardiac tissue by Shao, Hai, Sampson, Kevin J., Pormann, John B., Rose, Donald J., Henriquez, Craig S.

“…This paper describes a spatial discretization scheme for partial differential equation systems that contain anisotropic diffusion. The discretization method…”
Get full text