Search Results - "Samper, Enrique"

Targeted gene therapy and cell reprogramming in Fanconi anemia by Rio, Paula, Baños, Rocio, Lombardo, Angelo, Quintana‐Bustamante, Oscar, Alvarez, Lara, Garate, Zita, Genovese, Pietro, Almarza, Elena, Valeri, Antonio, Díez, Begoña, Navarro, Susana, Torres, Yaima, Trujillo, Juan P, Murillas, Rodolfo, Segovia, Jose C, Samper, Enrique, Surralles, Jordi, Gregory, Philip D, Holmes, Michael C, Naldini, Luigi, Bueren, Juan A

“…Gene targeting is progressively becoming a realistic therapeutic alternative in clinics. It is unknown, however, whether this technology will be suitable for…”
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Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice by Xia, Xu-Gang, Zhou, Hongxia, Samper, Enrique, Melov, Simon, Xu, Zuoshang

“…RNA interference (RNAi) has been used increasingly for reverse genetics in invertebrates and mammalian cells, and has the potential to become an alternative to…”
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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang by Samper, Enrique, Goytisolo, Fermín A, Slijepcevic, Predrag, van Buul, Paul P W, Blasco, María A

“…Ku86 together with Ku70, DNA‐PKcs, XRCC4 and DNA ligase IV forms a complex involved in repairing DNA double‐strand breaks (DSB) in mammals. Yeast Ku has an…”
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Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ by Lucas, Daniel, Delgado-García, José M, Escudero, Beatriz, Albo, Carmen, Aza, Ana, Acín-Pérez, Rebeca, Torres, Yaima, Moreno, Paz, Enríquez, José Antonio, Samper, Enrique, Blanco, Luis, Fairén, Alfonso, Bernad, Antonio, Gruart, Agnès

“…A definitive consequence of the aging process is the progressive deterioration of higher cognitive functions. Defects in DNA repair mechanisms mostly result in…”
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The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang by Goytisolo, Fermı́n A., Samper, Enrique, Edmonson, Scott, Taccioli, Guillermo E., Blasco, Marı́a A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice by Hande, M. Prakash, Samper, Enrique, Lansdorp, Peter, Blasco, María A.

“…To study the effect of continued telomere shortening on chromosome stability, we have analyzed the telomere length of two individual chromosomes (chromosomes 2…”
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Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair by Lucas, Daniel, Escudero, Beatriz, Ligos, José Manuel, Segovia, Jose Carlos, Estrada, Juan Camilo, Terrados, Gloria, Blanco, Luis, Samper, Enrique, Bernad, Antonio

“…Polymerase micro (Polmicro) is an error-prone, DNA-directed DNA polymerase that participates in non-homologous end-joining (NHEJ) repair. In vivo, Polmicro…”
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Polμ deficiency increases resistance to oxidative damage and delays liver aging by Escudero, Beatriz, Lucas, Daniel, Albo, Carmen, Dhup, Suveera, Bacher, Jeff W, Sánchez-Muñoz, Aránzazu, Fernández, Margarita, Rivera-Torres, José, Carmona, Rosa M, Fuster, Encarnación, Carreiro, Candelas, Bernad, Raquel, González, Manuel A, Andrés, Vicente, Blanco, Luis, Roche, Enrique, Fabregat, Isabel, Samper, Enrique, Bernad, Antonio

“…Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ(-/-)) show altered hematopoiesis homeostasis and…”
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Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum by Mak, Tak W, de la Pompa, José Luis, Timmerman, Luika A, Takimoto, Hiroaki, Yoshida, Hiroki, Elia, Andrew J, Samper, Enrique, Potter, Julia, Wakeham, Andrew, Marengere, Luc, Langille, B. Lowell, Crabtree, Gerald R

“…In lymphocytes, the expression of early immune response genes is regulated by NF-AT transcription factors, which translocate to the nucleus after…”
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Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells by Samper, Enrique, Fernández, Piedad, Eguı́a, Raúl, Martı́n-Rivera, Luis, Bernad, Antonio, Blasco, Marı́a A., Aracil, Miguel

“…Telomere length must be tightly regulated in highly proliferative tissues, such as the lymphohematopoietic system. Under steady-state conditions, the levels…”
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Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte renewal by Lara-Astiaso, David, Izarra, Alberto, Estrada, Juan Camilo, Albo, Carmen, Moscoso, Isabel, Samper, Enrique, Moncayo, Javier, Solano, Abelardo, Bernad, Antonio, Díez-Juan, Antonio

“…Cardiac healing, which follows myocardial infarction, is a complex process guided by intricate interactions among different components. Some resident cell…”
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The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine by NIETO, Maria, SAMPER, Enrique, FRAGA, Mario F, DE BUITRAGO, Gonzalo Gonzalez, ESTELLER, Manel, SERRANO, Manuel

“…The absence of functional p53 has complex consequences on the cellular responses to cytotoxic drugs. Here, we have examined the role of p53 in the response to…”
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Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts by Prieto, Ignacio, Zambrano, Alberto, Laso, Javier, Aranda, Ana, Samper, Enrique, Monsalve, María

“…Oxidative stress is known to induce early replicative senescence. Senescence has been proposed to work as a barrier to immortalization and tumor development…”
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P-185 - Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts by Prieto, Ignacio, Zambrano, Alberto, Laso, Javier, Aranda, Ana, Samper, Enrique, Monsalve, Maria

“…Oxidative stress is known to induce early replicative senescence. Senescence has been proposed to work as a barrier to immortalization and tumor development…”
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Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts by Prieto, Ignacio, Zambrano, Alberto, Laso, Javier, Aranda, Ana, Samper, Enrique, Monsalve, Maria

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Polμ deficiency induces moderate shortening of P53−/− mouse lifespan and modifies tumor spectrum by Escudero, Beatriz, Herrero, Diego, Torres, Yaima, Cañón, Susana, Molina, Antonio, Carmona, Rosa M., Suela, Javier, Blanco, Luis, Samper, Enrique, Bernad, Antonio

“…•Polμ deficiency substantially modifies tumorigenesis in P53−/− mice.•Polμ deficiency increases sarcoma incidence in P53 deficient mice.•Polμ−/−P53−/− mice…”
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Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas by Samper, Enrique, Morgado, Lucia, Estrada, Juan C., Bernad, Antonio, Hubbard, Alan, Cadenas, Susana, Melov, Simon

“…Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are currently not well understood. To better define these…”
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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts by Campisi, Judith, Parrinello, Simona, Samper, Enrique, Krtolica, Ana, Goldstein, Joshua, Melov, Simon

“…Most mammalian cells do not divide indefinitely, owing to a process termed replicative senescence. In human cells, replicative senescence is caused by telomere…”
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Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc−/− mice with short telomeres by Samper, Enrique, Flores, Juana M, Blasco, María A

“…Reconstitution of telomerase activity is proposed as a potential gene therapy to prevent, or rescue, age‐related diseases produced by critical telomere…”
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA by Blasco, María A, Lee, Han-Woong, Hande, M.Prakash, Samper, Enrique, Lansdorp, Peter M, DePinho, Ronald A, Greider, Carol W

“…To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component ( mTR) was deleted from the mouse germline. mTR −/− mice lacked…”
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