Search Results - "Sampaio Nogueira, Carlos Emidio"
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ADMET study and inhibition of Staphylococcus aureus efflux pumps by a synthetic p-aminochalcone
Published in Results in Chemistry (01-01-2024)“…[Display omitted] Bacterial resistance is a global health problem that needs to be solved through discovery of new therapeutic strategies. This study aimed to…”
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Potentiating activity of Norfloxacin by synthetic chalcones against NorA overproducing Staphylococcus aureus
Published in Microbial pathogenesis (01-06-2021)“…Staphylococcus aureus is responsible for a series of infections occurring in both human and animal hosts. S. aureus SA1199B is a strain resistant to…”
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Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L
Published in Fundamental & clinical pharmacology (01-08-2023)“…The rising of diseases caused by multidrug‐resistant bacteria has encouraged researchers to explore more antimicrobial substances, as well as chemicals capable…”
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Mechanism of the lethal effect of Riparin E against bacterial and yeast strains
Published in Microbial pathogenesis (01-08-2021)“…Riparins are alkamides naturally found in the fruits of Aniba riparia (Nees) Mez, but currently synthetic molecules as Riparin E (Rip-E) can be obtained…”
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Potentiation of antibiotic activity, and efflux pumps inhibition by (2E)‐1‐(4‐aminophenyl)‐3‐(4‐fluorophenyl)prop‐2‐en‐1‐one
Published in Fundamental & clinical pharmacology (01-12-2022)“…In recent years, bacterial resistance to traditional drugs has increased, and the need to find new effective antibiotics to treat infections caused by…”
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Synthesis, antibiotic modifying activity, ADMET study and molecular docking of chalcone (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying MepA efflux pumps
Published in Archives of microbiology (01-01-2022)“…The Staphylococcus aureus bacteria is a Gram-positive, immobile, non-spore bacterium, with catalase and positive coagulase, among other characteristics. It is…”
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Chalcones Isolated from Arrabidaea brachypoda Flowers as Inhibitors of NorA and MepA Multidrug Efflux Pumps of Staphylococcus aureus
Published in Antibiotics (Basel) (20-06-2020)“…Bacterial resistance to antibiotics has become a public health issue around the world. The present study aimed to evaluate the antibacterial activity of…”
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Structural, Vibrational and Electrochemical Analysis and Antibacterial Potential of Isomeric Chalcones Derived from Natural Acetophenone
Published in Applied sciences (01-07-2020)“…Background: Chalcones are part of a family of small phenolic compounds that are being extensively studied for presenting a diversity of molecular structures…”
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Aminophenyl chalcones potentiating antibiotic activity and inhibiting bacterial efflux pump
Published in European journal of pharmaceutical sciences (01-03-2021)“…•The APCHAL chalcone presented a synergistic effect with gentamicin.•When a chlorine radical was added to this structure (ACLOPHENYL), the synergistic effect…”
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Anxiolytic-like effect of chalcone N-{4’[(2E)-3-(3-nitrophenyl)-1-(phenyl)prop-2-en-1-one]} acetamide on adult zebrafish (Danio rerio): Involvement of the 5-HT system
Published in Biochemical and biophysical research communications (28-05-2020)“…The action of anxiolytic compounds that act on selective serotonin receptors (SSRIs) have been scarcely evaluated. Serotonergic drugs have been shown to be…”
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Structural characterization, electronic properties, and anxiolytic-like effect in adult zebrafish (Danio rerio) of cinnamaldehyde chalcone
Published in Journal of molecular structure (15-12-2020)“…•Chalcone (2E, 4E) −1- (2‑hydroxy-3,4,6-trimethoxyphenyl)−5-phenylpenta-2,4‑dien‑1-one, was synthesized from natural products…”
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Structural characterization, DFT calculations, ADMET studies, antibiotic potentiating activity, evaluation of efflux pump inhibition and molecular docking of chalcone (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
Published in Journal of molecular structure (05-03-2021)“…•A chalcone was synthesized by Claisen-Schmidt condensation reaction.•Structural, electronic and reactivity properties were obtained using DFT.•ADMET studies…”
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Antibacterial and antibiotic modifying activity, ADMET study and molecular docking of synthetic chalcone (E)-1-(2-hydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying NorA and MepA efflux pumps
Published in Biomedicine & pharmacotherapy (01-08-2021)“…A large number of infections are caused by multi-resistant bacteria worldwide, adding up to a figure of around 700,000 deaths per year. Because of that many…”
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Riparin-B as a Potential Inhibitor of AdeABC Efflux System from Acinetobacter baumannii
Published in Evidence-based complementary and alternative medicine (2023)“…Acinetobacter baumannii is an important opportunistic pathogen that causes serious health-related infections, especially in intensive care units. The present…”
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Modulatory Effect of Croton heliotropiifolius Kunth Ethanolic Extract on Norfloxacin Resistance in Staphylococcus aureus
Published in Drugs and drug candidates (22-12-2023)“…The high frequency of infectious diseases has spurred research into effective tactics to combat microorganisms that are resistant to several drugs. The…”
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Inhibition of NorA efflux pump of Staphylococcusaureus by anacardic acids isolated from the cashew nutshell liquid of Anacardiumoccidentale L
Published in Fundamental & clinical pharmacology (01-08-2023)“…The rising of diseases caused by multidrug‐resistant bacteria has encouraged researchers to explore more antimicrobial substances, as well as chemicals capable…”
Get full text
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