Search Results - "Samoylenko, Igor"

Pinpointing the tumor-specific T cells via TCR clusters by Goncharov, Mikhail M, Bryushkova, Ekaterina A, Sharaev, Nikita I, Skatova, Valeria D, Baryshnikova, Anastasiya M, Sharonov, George V, Karnaukhov, Vadim, Vakhitova, Maria T, Samoylenko, Igor V, Demidov, Lev V, Lukyanov, Sergey, Chudakov, Dmitriy M, Serebrovskaya, Ekaterina O

“…Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell…”
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Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB–IVM1c melanoma by Malvehy, Josep, Samoylenko, Igor, Schadendorf, Dirk, Gutzmer, Ralf, Grob, Jean-Jacques, Sacco, Joseph J, Gorski, Kevin S, Anderson, Abraham, Pickett, Cheryl A, Liu, Kate, Gogas, Helen

“…BackgroundTalimogene laherparepvec (T-VEC), an oncolytic virus, was designed to selectively replicate in and lyse tumor cells, releasing tumor-derived antigen…”
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Measuring Intratumoral Heterogeneity of Immune Repertoires by Yuzhakova, Diana Vladimirovna, Volchkova, Lilia N, Pogorelyy, Mikhail Valerievich, Serebrovskaya, Ekaterina O, Shagina, Irina A, Bryushkova, Ekaterina A, Nakonechnaya, Tatiana O, Izosimova, Anna V, Zavyalova, Daria S, Karabut, Maria M, Izraelson, Mark, Samoylenko, Igor V, Zagainov, Vladimir E, Chudakov, Dmitriy M, Zagaynova, Elena V, Sharonov, George Vladimirovich

“…There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid…”
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Immune Pathogenesis of COVID-19 Intoxication: Storm or Silence? by Kiselevskiy, Mikhail, Shubina, Irina, Chikileva, Irina, Sitdikova, Suria, Samoylenko, Igor, Anisimova, Natalia, Kirgizov, Kirill, Suleimanova, Amina, Gorbunova, Tatyana, Varfolomeeva, Svetlana

“…Dysregulation of the immune system undoubtedly plays an important and, perhaps, determining role in the COVID-19 pathogenesis. While the main treatment of the…”
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Real-World Experience with Targeted Therapy in BRAF Mutant Advanced Melanoma Patients: Results from a Multicenter Retrospective Observational Study Advanced Melanoma in Russia (Experience) (ADMIRE) by Orlova, Kristina V., Ledin, Evgeniy V., Zhukova, Natalia V., Orlova, Rashida V., Karabina, Elena V., Volkonskiy, Mikhail V., Stroyakovskiy, Daniil L., Yurchenkov, Aleksandr N., Protsenko, Svetlana A., Novik, Alexey V., Vorotilina, Ludmila V., Moiseenko, Fedor V., Chang, Victor L., Kazmin, Aleksandr I., Tkachenko, Svetlana A., Gamaunov, Sergey V., Naskhletashvili, David R., Samoylenko, Igor V., Vikhrova, Anastasia S., Utyashev, Igor A., Kharkevich, Galina Yu, Petenko, Natalia N., Shubina, Irina Zh, Demidov, Lev V.

“…Clinical trials of targeted therapy (TT) and immunotherapy (IT) for highly aggressive advanced melanoma have shown marked improvements in response and survival…”
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Screening for Melanoma and Other Skin Cancer Shows a Higher Early Melanoma Incidence: Social Educational Program "Life Fear-Free" by Demidov, Lev, Samoylenko, Igor, Vand, Nina, Utyashev, Igor, Shubina, Irina, Sinelnikov, Igor

“…The screening program Life Fear-Free (LFF) aimed at early diagnosis of cutaneous melanoma (CM) was introduced in Samara, Chelyabinsk, Yekaterinburg, and…”
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Membrane (CD8⁺PD-1⁺ and CD4+PD-1⁺) and soluble (sPD-1 and sPD-L1) forms of immune checkpoints in melanoma, breast cancer, and oral mucosal cancer patients: A observational study by Zabotina, Tatiana N., Chertkova, Antonina I., Borunova, Anna A., Kushlinskii, Nikolay E., Gershtein, Elena S., Zakharova, Elena N., Shoua, Esma K., Tsiklauri, Vasily T., Samoylenko, Igor V., Khoroshilov, Maxim V., Kadagidze, Zaira G.

“…Background. The PD-1/PD-L1 pathway plays an important role in tumor evasion from immunological surveillance. In addition to the membrane forms of PD-1 and…”
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Efficacy and safety of nurulimab+prolgolimab with continued prolgolimab therapy compared to prolgolimab alone as first-line therapy in patients with unresectable or metastatic melanoma: final results of the phase II OBERTON clinical study by Samoylenko, Igor V., Demidov, Lev V., Moiseenko, Fedor V., Dvorkin, Mikhail V., Demidova, Svetlana A., Protsenko, Svetlana A., Stroyakovskiy, Daniil L., Kozlov, Vadim V., Odintsova, Svetlana V., Kirtbaya, Dmitry V., Tantsyrev, Denis A., Mochalova, Anastasia S., Orlova, Rashida V., Mukhametshina, Guzel Z., Fadeeva, Natalia V., Fomin, Evgeny A., Chapko, Yana S., Tarasova, Anna V., Ermakov, Nikolay B., Shemerovskiy, Alexander K., Vaschenko, Vera A., Chistyakov, Valery M., Zinkina-Orikhan, Arina V., Lin'kova, Yulia N., Kryukov, Fedor B., Sorokina, Irina V., Siliutina, Anna A.

“…Background. In an era of breakthroughs in cancer immunotherapy, CheckMate 067 studies declared the combination of PD-1 and CTLA-4 inhibitors a new standard of…”
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Comparison of adjuvant targeted and anti-PD1 immunotherapy in BRAF-mutated stage III cutaneous melanoma: Retrospective, single center cohort study by Akhmetianova, Angelina, Orlova, Kristina V., Nazarova, Valery V., Baryshnikov, Kirill A., Samoylenko, Igor, Ivanilov, Kirill, Demidov, Lev V.

“…e21558 Background: Targeted therapy (TT) and anti-PD1 immunotherapy (IT) are standard of adjuvant stage III melanoma treatment. However, no comparative…”
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Evaluation of treatment patterns in patients with BRAF-mutant cutaneous melanoma in adjuvant setting in real practice by Samoylenko, Igor, Stroganova, Anna, Shakhray, Ekaterina, Orlova, Kristina V., Akhmetianova, Angelina, Demidov, Lev V.

“…e21573 Background: Mutation in BRAF is a crucial biomarker for treatment choice in patient with locally advanced or metastatic melanoma. In patient with BRAF…”
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Mucosal melanoma treatment patterns and outcomes in real clinical practice: Single institution experience by Samoylenko, Igor, Stroganova, Anna, Orlova, Kristina V., Kuzmenko, Angelina, Martynova, Margarita, Kogai, Ekaterina, Nazarova, Valery V., Petenko, Natalia N., Demidov, Lev V.

“…e21571 Background: Mucosal melanoma (MM) is a challenging malignancy to diagnose and treat, even with the advent of modern drug therapies. There is a lack of…”
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Intralesional anti-PD1 treatment in patients with metastatic melanoma: The pilot study by Samoylenko, Igor, Korotkova, Olga V., Zabotina, Tatiana, Demidov, Lev V.

“…Abstract only 188 Background: Systemic anti-PD1 treatment is major advantage for metastatic melanoma patients over the last five years. Nevertheless up to the…”
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Multicenter clinical trial of DNA markers for non-invasive differential diagnosis of benign and malignant melanocytic lesions by Samoylenko, Igor, Zaretsky, Andrew R., Chudakova, Lidia V., Drozd, Oleg V., Garanina, Oksana E., Shlivko, Irena L., Yargunin, Sergey A., Zinovev, Grigory, Baryshnikov, Kirill A., Sinelnikov, Igor, Mikhaylova, Irina N., Vishnevskaya, Yana, Orlova, Kristina V., Demidov, Lev V.

“…e21550 Background: The differentiation between benign melanocytic neoplasms (nevi) and malignant melanocytic neoplasms (melanoma) presents a significant…”
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Preoperative conventional axillary ultrasound (AUS) and sonoelastography (SE) for predicting axillary lymph node metastasis in breast cancer patients by Petrovsky, Alexander, Khakurinova, Nafset, Sholokhov, Vladimir, Valiev, Ramiz, Berdnikov, Sergey, Samoylenko, Igor, Amosova, Victoria, Nechushkin, Mikhail

“…Abstract only e12074 Background: Patients with operable breast cancer (BC) and clinically negative lymph nodes (CNLN) usually undergo sentinel lymph node…”
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Multicenter prospective clinical trial of molecular genetic markers for non-invasive differential diagnosis of benign and malignant melanocytic skin lesions by Samoylenko, Igor, Zaretsky, Andrew R, Chudakova, Lidia V, Drozd, Oleg V, Garanina, Oksana E, Shlivko, Irena L, Zinovev, Grigory, Baryshnikov, Kirill A, Orlova, Kristina V., Maximova, Tatiana, Sinelnikov, Igor, Kim, Anna, Mikhaylova, Irina N., Demidov, Lev V.

“…e21581 Background: Improving the accuracy of non-invasive diagnosis of skin tumors is becoming an urgent problem, given the clear increase in the incidence of…”
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Recurrence-free survival (RFS) and objective response rate (ORR) phase 1/2 study of intralesional (IL) neoadjuvant (neo) anti-PD1 agents (aPD1) for stage IIIB-IV melanoma (MEL) by Samoylenko, Igor, Korotkova, Olga V., Shakhray, Ekaterina, Zabotina, Tatiana, Berdnikov, Sergey, Tabakov, Dmitry, Zakharova, Elena, Petenko, Natalia N., Demidov, Lev V.

“…Abstract only e14171 Background: We previously reported that aPD1 agents could be safely administered IL in patients (pts) with metastatic MEL with superficial…”
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Molecular mechanisms and time-dependent dynamics of hormesis, antagonism and radioprotective effects at combined ionizing irradiation of biological systems by Vysotskii, Vladimir I, Pinchuk, Anatolii A, Kornilova, Alla A, Samoylenko, Igor I

“…We study the time-dependent dynamics of formation, relaxation and self-reparation of DNA double-strand breaks at combined irradiation and the nonradiation…”
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Do we have early detection of cutaneous melanoma in Russia? Single-institution observational study by Samoylenko, Igor, Kharkevich, Galina, Utyashev, Igor A, Vishnevskaya, Yana V, Orlova, Kristina Vyacheslavovna, Demidov, Lev V.

“…Abstract only…”
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Paclitaxel and carboplatin chemotherapy in patients with metaststic melanoma refractory to BRAF/MEK inhibitors by Samoylenko, Igor, Kharkevich, Galina, Petenko, Natalia N., Orlova, Kristina V., Sinelnikov, Igor, Utyashev, Igor A, Vikhrova, Anastasia, Markina, Irina, Demidov, Lev V.

“…Abstract only…”
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Biomarkers in metastatic melanoma of the skin: can we more accurately choose the tactics of treating our patients? by Zaretsky, A. R., Demidov, L. V., Samoylenko, I. V.

“…With an increasing number of alternative effective therapies available for patients, there is an increasing need for a more accurate selection for therapy…”
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