Search Results - "Samovich, Svetlana N."

15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation by Nagasaki, Tadao, Schuyler, Alexander J, Zhao, Jinming, Samovich, Svetlana N, Yamada, Kazuhiro, Deng, Yanhan, Ginebaugh, Scott P, Christenson, Stephanie A, Woodruff, Prescott G, Fahy, John V, Trudeau, John B, Stoyanovsky, Detcho, Ray, Anuradha, Tyurina, Yulia Y, Kagan, Valerian E, Wenzel, Sally E

“…Altered redox biology challenges all cells, with compensatory responses often determining a cell's fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing…”
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Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure by Vats, Kavita, Kruglov, Oleg, Mizes, Alicia, Samovich, Svetlana N., Amoscato, Andrew A., Tyurin, Vladimir A., Tyurina, Yulia Y., Kagan, Valerian E., Bunimovich, Yuri L.

“…The ultraviolet B radiation (UVB) causes skin inflammation, which contributes to the causality and the exacerbation of a number of cutaneous diseases. However,…”
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Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators by Dar, Haider H, Mikulska-Ruminska, Karolina, Tyurina, Yulia Y, Luci, Diane K, Yasgar, Adam, Samovich, Svetlana N, Kapralov, Alexander A, Souryavong, Austin B, Tyurin, Vladimir A, Amoscato, Andrew A, Epperly, Michael W, Shurin, Galina V, Standley, Melissa, Holman, Theodore R, St Croix, Claudette M, Watkins, Simon C, VanDemark, Andrew P, Rana, Sandeep, Zakharov, Alexey V, Simeonov, Anton, Marugan, Juan, Mallampalli, Rama K, Wenzel, Sally E, Greenberger, Joel S, Rai, Ganesha, Bayir, Hülya, Bahar, Ivet, Kagan, Valerian E

“…Programmed ferroptotic death eliminates cells in all major organs and tissues with imbalanced redox metabolism due to overwhelming iron-catalyzed lipid…”
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P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis by Dar, Haider H, Epperly, Michael W, Tyurin, Vladimir A, Amoscato, Andrew A, Anthonymuthu, Tamil S, Souryavong, Austin B, Kapralov, Alexander A, Shurin, Galina V, Samovich, Svetlana N, St Croix, Claudette M, Watkins, Simon C, Wenzel, Sally E, Mallampalli, Rama K, Greenberger, Joel S, Bayır, Hülya, Kagan, Valerian E, Tyurina, Yulia Y

“…Total body irradiation (TBI) targets sensitive bone marrow hematopoietic cells and gut epithelial cells, causing their death and inducing a state of…”
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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression by Yang, Xin, Wang, Zhe, Samovich, Svetlana N, Kapralov, Alexander A, Amoscato, Andrew A, Tyurin, Vladimir A, Dar, Haider H, Li, Zhiming, Duan, Shoufu, Kon, Ning, Chen, Delin, Tycko, Benjamin, Zhang, Zhiguo, Jiang, Xuejun, Bayir, Hülya, Stockwell, Brent R, Kagan, Valerian E, Gu, Wei

“…Although the role of ferroptosis in killing tumor cells is well established, recent studies indicate that ferroptosis inducers also sabotage anti-tumor…”
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Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling by BEDNASH, JOSEPH S., KAGAN, VALERIAN E., ENGLERT, JOSHUA A., FARKAS, DANIELA, TYURINA, YULIA Y., TYURIN, VLADIMIR A., SAMOVICH, SVETLANA N., FARKAS, LASZLO, ELHANCE, AJIT, JOHNS, FINNY, LEE, HYUNWOOK, CHENG, LIJUN, MAJUMDAR, ABHISHEK, JONES, DANIEL, MEJIA, OSCAR ROSAS, RUANE-FOSTER, MARISA, LONDINO, JAMES D., MALLAMPALLI, RAMA K., ROBINSON, RICHARD T.

“…The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute…”
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Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs by Manivarma, Thiliban, Kapralov, Aleksandr A., Samovich, Svetlana N., Tyurina, Yulia Y., Tyurin, Vladimir A., VanDemark, Andrew P., Nowak, Wieslaw, Bayır, Hülya, Bahar, Ivet, Kagan, Valerian E., Mikulska-Ruminska, Karolina

“…Ferroptosis is a regulated form of cell death, the mechanism of which is still to be understood. 15-lipoxygenase (15LOX) complex with phosphatidylethanolamine…”
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Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death by Samovich, Svetlana N., Mikulska‐Ruminska, Karolina, Dar, Haider H., Tyurina, Yulia Y., Tyurin, Vladimir A., Souryavong, Austin B., Kapralov, Alexander A., Amoscato, Andrew A., Beharier, Ofer, Karumanchi, S. Ananth, St Croix, Claudette M., Yang, Xin, Holman, Theodore R., VanDemark, Andrew P., Sadovsky, Yoel, Mallampalli, Rama K., Wenzel, Sally E., Gu, Wei, Bunimovich, Yuri L., Bahar, Ivet, Kagan, Valerian E., Bayir, Hülya

“…The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached…”
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Effects of quinones and nitroazoles on free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol by Samovich, Svetlana N., Sladkova, Anastasia A., Sverdlov, Roman L., Edimecheva, Irina P., Shadyro, Oleg I.

“…[Display omitted] •Quinones, including doxorubicin, and nitroazoles effectively inhibit free-radical dephosphorylation of glycerol-1-phosphate.•The test…”
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Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death by Samovich, Svetlana N., Mikulska‐Ruminska, Karolina, Dar, Haider H., Tyurina, Yulia Y., Tyurin, Vladimir A., Souryavong, Austin B., Kapralov, Alexander A., Amoscato, Andrew A., Beharier, Ofer, Karumanchi, S. Ananth, St Croix, Claudette M., Yang, Xin, Holman, Theodore R., VanDemark, Andrew P., Sadovsky, Yoel, Mallampalli, Rama K., Wenzel, Sally E., Gu, Wei, Bunimovich, Yuri L., Bahar, Ivet, Kagan, Valerian E., Bayir, Hülya

“…The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached…”
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Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome by Kagan, Valerian E., Tyurina, Yulia Y., Mikulska-Ruminska, Karolina, Damschroder, Deena, Vieira Neto, Eduardo, Lasorsa, Alessia, Kapralov, Alexander A., Tyurin, Vladimir A., Amoscato, Andrew A., Samovich, Svetlana N., Souryavong, Austin B., Dar, Haider H., Ramim, Abu, Liang, Zhuqing, Lazcano, Pablo, Ji, Jiajia, Schmidtke, Michael W., Kiselyov, Kirill, Korkmaz, Aybike, Vladimirov, Georgy K., Artyukhova, Margarita A., Rampratap, Pushpa, Cole, Laura K., Niyatie, Ammanamanchi, Baker, Emma-Kate, Peterson, Jim, Hatch, Grant M., Atkinson, Jeffrey, Vockley, Jerry, Kühn, Bernhard, Wessells, Robert, van der Wel, Patrick C. A., Bahar, Ivet, Bayir, Hülya, Greenberg, Miriam L.

“…Barth syndrome (BTHS) is a life-threatening genetic disorder with unknown pathogenicity caused by mutations in TAFAZZIN ( TAZ ) that affect remodeling of…”
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15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation by Nagasaki, Tadao, Schuyler, Alexander J, Zhao, Jinming, Samovich, Svetlana N, Yamada, Kazuhiro, Deng, Yanhan, Ginebaugh, Scott P, Christenson, Stephanie A, Woodruff, Prescott G, Fahy, John V, Trudeau, John B, Stoyanovsky, Detcho, Ray, Anuradha, Tyurina, Yulia Y, Kagan, Valerian E, Wenzel, Sally E

“…Altered redox biology challenges all cells, with compensatory responses often determining a cell's fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing…”
Get full text