Search Results - "Samorì, Bruno"
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1
Single-Molecule Studies of Intrinsically Disordered Proteins
Published in Chemical reviews (26-03-2014)Get full text
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Conformational equilibria in monomeric alpha-synuclein at the single-molecule level
Published in PLoS biology (01-01-2008)“…Human alpha-Synuclein (alphaSyn) is a natively unfolded protein whose aggregation into amyloid fibrils is involved in the pathology of Parkinson disease. A…”
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Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy
Published in Biology (Basel, Switzerland) (16-09-2022)“…Prion diseases are neurodegenerative disorders characterized by the presence of oligomers and amyloid fibrils. These are the result of protein aggregation…”
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Probing Italy: A Scanning Probe Microscopy Storyline
Published in Micro (01-06-2023)“…Starting from the late 1980’s, scanning probe microscopy has progressively diffused in Italy until today. In this paper, we provide a brief account of the main…”
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Observing the osmophobic effect in action at the single molecule level
Published in Proteins, structure, function, and bioinformatics (01-07-2011)“…Protecting osmolytes are widespread small organic molecules able to stabilize the folded state of most proteins against various denaturing stresses in vivo…”
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DNA Codes for Nanoscience
Published in Angewandte Chemie International Edition (11-02-2005)“…The nanometer scale is a special place where all sciences meet and develop a particularly strong interdisciplinarity. While biology is a source of inspiration…”
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Mastering the complexity of DNA nanostructures
Published in Trends in biotechnology (Regular ed.) (01-05-2006)“…The self-assembly of oligodeoxynucleotides is a versatile and powerful tool for the construction of objects in the nanoscale. The strictly information-driven…”
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Single-Molecule-Level Evidence for the Osmophobic Effect
Published in Angewandte Chemie International Edition (02-05-2011)Get full text
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The State of the Art of Chemical Biology
Published in Chembiochem : a European journal of chemical biology (05-01-2009)Get full text
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How Strong Is the Coordination Bond between a Histidine Tag and Ni - Nitrilotriacetate? An Experiment of Mechanochemistry on Single Molecules
Published in Angewandte Chemie International Edition (03-01-2000)“…Isolation of a His‐tagged protein by means of a Ni – nitrilotriacetate‐functionalized chromatographic matrix or biosensor was simulated in a single‐molecule…”
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Mapping the Intrinsic Curvature and Flexibility along the DNA Chain
Published in Proceedings of the National Academy of Sciences - PNAS (13-03-2001)“…The energy of DNA deformation plays a crucial and active role in its packaging and its function in the cell. Considerable effort has gone into developing…”
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The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease
Published in The Journal of biological chemistry (13-06-2008)“…Oxidative stress appears to be directly involved in the pathogenesis of Parkinson disease. Several different pathways have been identified for the production…”
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Chip cleaning and regeneration for electrochemical sensor arrays
Published in Thin solid films (02-04-2010)“…Sensing systems based on electrochemical detection have generated great interest because electronic readout may replace conventional optical readout in…”
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14
Recognition of the DNA Sequence by an Inorganic Crystal Surface
Published in Proceedings of the National Academy of Sciences - PNAS (15-10-2002)“…The sequence-dependent curvature is generally recognized as an important and biologically relevant property of DNA because it is involved in the formation and…”
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Screen-printed electrodes based on carbon nanotubes and cytochrome P450scc for highly sensitive cholesterol biosensors
Published in Biosensors & bioelectronics (15-09-2008)“…This paper is concerned with an investigation of electron transfer between cytochrome P450scc (CYP11A1) immobilized on nanostructured rhodium–graphite…”
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Pathogenic Mutations Shift the Equilibria of α-Synuclein Single Molecules towards Structured Conformers
Published in Chembiochem : a European journal of chemical biology (05-01-2009)“…α-synuclein (α-Syn) is an abundant brain protein whose mutations have been linked to early-onset Parkinson's disease (PD). We recently demonstrated, by means…”
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CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement
Published in IEEE journal of solid-state circuits (01-12-2006)“…This paper presents a fully electronic label-free DNA chip in 0.5-mum CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated…”
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Harald Fuchs, Bharat Bhushan (Eds.): Biosystems investigated by scanning-probe microscopy
Published in Analytical and bioanalytical chemistry (2011)Get full text
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Worm-Like Ising Model for Protein Mechanical Unfolding under the Effect of Osmolytes
Published in Biophysical journal (18-01-2012)“…We show via single-molecule mechanical unfolding experiments that the osmolyte glycerol stabilizes the native state of the human cardiac I27 titin module…”
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Open source platform for the execution and analysis of mechanical refolding experiments
Published in Bioinformatics (01-02-2011)“…Single-molecule force spectroscopy has facilitated the experimental investigation of biomolecular force-coupled kinetics, from which the kinetics at zero force…”
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