Search Results - "Samir A. Carvalho"

Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives by Santiago, Natália N, de Alcântara, Giulianna P, da Costa, Juliana S, Carvalho, Samir A, Barbosa, Juliana M C, Salomão, Kelly, de Castro, Solange L, Pereira, Henrique M G, da Silva, Edson F

“…Approximately, 5-7 million people are infected with T. cruzi in the world, and approximately 10,000 people per year die of complications linked to this…”
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Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates by do Nascimento, Mayara S S, Câmara, Vitória R F, da Costa, Juliana S, Barbosa, Juliana M C, Lins, Alessandra S M, Salomão, Kelly, de Castro, Solange L, Carvalho, Samir A, da Silva, Edson F, Fraga, Carlos A M

“…Although several research efforts have been made worldwide to discover novel drug candidates for the treatment of Chagas disease, the nitroimidazole drug…”
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Synthesis and activity of benzimidazole N-Acylhydrazones against Trypanosoma cruzi, Leishmania amazonensis and Leishmania infantum by Ramos, Laís G., de Souza, Kátia R., Barbosa, Juliana M.C., Salomão, Kelly, Sales Junior, Policarpo A., Pereira, Valéria R.A., Murta, Silvane M.F., Ferreira, Rafaela S., Bernardes, Talita C.D., Wardell, Solange M.S.V., Wardell, James L., Boechat, Nubia, Carvalho, Samir A.

“…[Display omitted] •Planning of new Benzimidazole N-acylhydrazones with antitrypanosomal activity.•Biological evaluation of the compounds against T. cruzi…”
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Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents by Carvalho, Samir A., Feitosa, Larisse O., Soares, Márcio, Costa, Thadeu E.M.M., Henriques, Maria G., Salomão, Kelly, de Castro, Solange L., Kaiser, Marcel, Brun, Reto, Wardell, James L., Wardell, Solange M.S.V., Trossini, Gustavo H.G., Andricopulo, Adriano D., da Silva, Edson F., Fraga, Carlos A.M.

“…We report herein the synthesis and trypanocidal profile of new (E)-cinnamic N-acylhydrazones (NAHs) designed by exploiting molecular hybridization between the…”
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Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives by Carvalho, Samir A., da Silva, Edson F., de Souza, Marcus V.N., Lourenço, Maria C.S., Vicente, Felipe R.

“…The present article describes a series of ten new trans-cinnamic acid hydrazide derivatives, which were synthesized and evaluated for their in vitro…”
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Phenoxyacetohydrazones against Trypanosoma cruzi by Capelini, Camila, de Souza, Kátia R., Barbosa, Juliana M. C., Salomão, Kelly, Sales Junior, Policarpo A., Murta, Silvane M. F., Wardell, Solange M. S. V., Wardell, James L., da Silva, Edson F., Carvalho, Samir A.

“…Herein, we reported the design, synthesis, antitrypanosomal and cytotoxic evaluation of a new phenoxyacetohydrazones series. All derivatives were assayed…”
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Crystal structures and Hirshfeld surface analyses of (E)-N'-benzyl-idene-2-oxo-2H-chromene-3-carbo-hydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N'-(3,4,5-trimeth-oxybenzyl-idene)-2H-chromene-3-carbohydrazide: lattice energy and inter-molecular inter-action energy calculations for the former by Gomes, Ligia R, Low, John Nicolson, Wardell, James L, Capelini, Camiola, Câmara, Vitoria R F, da Silva, Edson F, Carvalho, Samir A

“…The crystal structures of the disordered hemi-DMSO solvate of (E)-2-oxo-N'-(3,4,5-tri-meth-oxy-benzyl-idene)-2H-chromene-3-carbohydrazide,…”
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Crystal structures and Hirshfeld surface analyses of (E)-N′-benzylidene-2-oxo-2H-chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide: lattice energy and intermolecular interaction energy calculations for the former by Ligia R. Gomes, John Nicolson Low, James L. Wardell, Camiola Capelini, Vitoria R.F. Câmara, Edson F. da Silva, Samir A. Carvalho

“…The crystal structures of the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide, C20H18N2O6·0.5C2H6OS,…”
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Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues by Carvalho, Samir A., da Silva, Edson F., Santa-Rita, Ricardo M., de Castro, Solange L., Fraga, Carlos A.M.

“…The synthesis of the new powerful trypanocidal agent brazilizone A ( 4k) (IC 50/24 h = 5.3 μM) is reported. In this work we reported the synthesis and the…”
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Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives by Carvalho, Samir A., Lopes, Francisco A.S., Salomão, Kelly, Romeiro, Nelilma C., Wardell, Solange M.S.V., de Castro, Solange L., da Silva, Edson F., Fraga, Carlos A.M.

“…We describe herein a 3D-QSAR model constructed with trypanocidal agents structurally-related to Brazilizone A ( 2) and the discovery of the…”
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Different mol-ecular conformations in the crystal structures of three 5-nitro-imidazolyl derivatives by Osorio, Luis F B, Carvalho, Samir A, da Silva, Edson F, Fraga, Carlos A M, Wardell, Solange M S V, Milne, Bruce F, Wardell, James L, Harrison, William T A

“…The crystal structures of ( )-1-methyl-5-nitro-1 -imidazole-2-carbaldehyde -benzyl-oxime, C H N O , (I), ( )-1-methyl-5-nitro-1 -imidazole-2-carb-alde-hyde…”
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Different molecular conformations in the crystal structures of three 5-nitroimidazolyl derivatives by Osorio, Luis F. B., Carvalho, Samir A., Silva, Edson F. da, Fraga, Carlos A. M., Wardell, Solange M. S. V., Milne, Bruce F., Wardell, James L., Harrison, William T. A.

“…The crystal structures of ( E )-1-methyl-5-nitro-1 H -imidazole-2-carbaldehyde O -benzyloxime, C 12 H 12 N 4 O 3 , (I), ( E )-1-methyl-5-nitro-1 H…”
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(2E)-N'-Benzoyl-3-(4-nitro-phen-yl)prop-2-enohydrazide by Carvalho, Samir A, da Silva, Edson F, de Souza, Marcus V N, Tiekink, Edward R T, Wardell, James L, Wardell, Solange M S V

“…In the title compound, C(16)H(13)N(3)O(4), the dihedral angle between the terminal benzene rings is 14.02 (7)°. The carbonyl groups are anti with respect to…”
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Crystal structures and Hirshfeld surface analyses of (E)-N′-benzylidene-2-oxo-2H-chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide: lattice energy and intermolecular interaction energy calculations for the former. Corrigendum by Ligia R. Gomes, John Nicolson Low, James L. Wardell, Camila Capelini, José Daniel Figueroa Villar, Vitoria R.F. Câmara, Edson F. da Silva, Samir A. Carvalho

“…In the paper by Gomes et al. [Acta Cryst. (2019), E75, 1403–1410], there was an error and omission in the author and affiliation list…”
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Crystal structures and Hirshfeld surface analyses of ( E )- N ′-benzylidene-2-oxo-2 H -chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of ( E )-2-oxo- N ′-(3,4,5-trimethoxybenzylidene)-2 H -chromene-3-carbohydrazide: lattice energy and intermolecular interaction energy calculations for the former. Corrigendum by Gomes, Ligia R., Low, John Nicolson, Wardell, James L., Capelini, Camila, Figueroa Villar, José Daniel, Câmara, Vitoria R.F., da Silva, Edson F., Carvalho, Samir A.

“…In the paper by Gomes et al. [ Acta Cryst. (2019), E 75 , 1403–1410], there was an error and omission in the author and affiliation list…”
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Erratum: Crystal structures and Hirshfeld surface analyses of ( E )- N '-benzyl-idene-2-oxo-2 H -chromene-3-carbo-hydrazide and the disordered hemi-DMSO solvate of ( E )-2-oxo- N '-(3,4,5-trimeth-oxybenzyl-idene)-2 H -chromene-3-carbohydrazide: lattice energy and inter-molecular inter-action energy calculations for the former. Corrigendum by Gomes, Ligia R, Low, John Nicolson, Wardell, James L, Capelini, Camila, Figueroa Villar, José Daniel, Câmara, Vitoria R F, da Silva, Edson F, Carvalho, Samir A

“…[This corrects the article DOI: 10.1107/S2056989019012015.]…”
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Erratum: Crystal structures and Hirshfeld surface analyses of (E)-N'-benzyl-idene-2-oxo-2H-chromene-3-carbo-hydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N'-(3,4,5-trimeth-oxybenzyl-idene)-2H-chromene-3-carbohydrazide: lattice energy and inter-molecular inter-action energy calculations for the former. Corrigendum by Gomes, Ligia R, Low, John Nicolson, Wardell, James L, Capelini, Camila, Figueroa Villar, José Daniel, Câmara, Vitoria R F, da Silva, Edson F, Carvalho, Samir A

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Crystal structures and Hirshfeld surface analyses of ( E )- N ′-benzylidene-2-oxo-2 H -chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of ( E )-2-oxo- N ′-(3,4,5-trimethoxybenzylidene)-2 H -chromene-3-carbohydrazide: lattice energy and intermolecular interaction energy calculations for the former by Gomes, Ligia R., Low, John Nicolson, Wardell, James L., Capelini, Camiola, Câmara, Vitoria R.F., Silva, Edson F. da, Carvalho, Samir A.

“…The crystal structures of the disordered hemi-DMSO solvate of ( E )-2-oxo- N ′-(3,4,5-trimethoxybenzylidene)-2 H -chromene-3-carbohydrazide, C 20 H 18 N 2 O 6…”
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Crystal structures and Hirshfeld surface analyses of ( E )- N '-benzyl-idene-2-oxo-2 H -chromene-3-carbo-hydrazide and the disordered hemi-DMSO solvate of ( E )-2-oxo- N '-(3,4,5-trimeth-oxybenzyl-idene)-2 H -chromene-3-carbohydrazide: lattice energy and inter-molecular inter-action energy calculations for the former by Gomes, Ligia R, Low, John Nicolson, Wardell, James L, Capelini, Camiola, Câmara, Vitoria R F, da Silva, Edson F, Carvalho, Samir A

“…The crystal structures of the disordered hemi-DMSO solvate of ( )-2-oxo- '-(3,4,5-tri-meth-oxy-benzyl-idene)-2 -chromene-3-carbohydrazide, C H N O ·0.5C H OS,…”
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Crystal structures and Hirshfeld surface analyses of (E)-N′-benzyl­idene-2-oxo-2H-chromene-3-carbo­hydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimeth­oxybenzyl­idene)-2H-chromene-3-carbohydrazide: lattice energy and inter­molecular inter­action energy calculations for the former. Corrigendum by Gomes, Ligia R., Low, John Nicolson, Wardell, James L., Capelini, Camila, Figueroa Villar, José Daniel, Câmara, Vitoria R.F., da Silva, Edson F., Carvalho, Samir A.

“…Erratum to Acta Cryst. (2019), E 75 , 1403–1410 . In the paper by Gomes et al. [ Acta Cryst. (2019), E 75 , 1403–1410 ], there was an error and omission in the…”
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