Maternal lipids are associated with newborn adiposity, independent of GDM status, obesity and insulin resistance: a prospective observational cohort study

Objective To determine the association between maternal lipaemia and neonatal anthropometrics in Malaysian mother–offspring pairs. Design Prospective observational cohort study. Setting Single tertiary multidisciplinary antenatal clinic in Malaysia. Population A total of 507 mothers: 145 with gestat...

Full description

Saved in:

Bibliographic Details
Published in:	BJOG : an international journal of obstetrics and gynaecology Vol. 127; no. 4; pp. 490 - 499
Main Authors:	Samsuddin, S, Arumugam, PA, Md. Amin, Md.S, Yahya, A, Musa, N, Lim, L‐L, Paramasivam, SS, Ratnasingam, J, Ibrahim, L, Chooi, KC, Tan, ATB, Tan, PC, Omar, SZ, Samingan, N, Ahmad Kamar, A, Anuar Zaini, A, Jalaluddin, MY, Vethakkan, SR
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-03-2020
Subjects:	Adipose tissue Adult Asian Asian Continental Ancestry Group Birth Weight Body fat Body Mass Index Body weight gain Case-Control Studies Cohort analysis Diabetes mellitus Fasting Female Fetal Macrosomia - blood Fetal Macrosomia - epidemiology Gestation Gestational diabetes gestational weight gain Glucose Glucose tolerance Health risk assessment Humans Hyperlipidemias - blood Hyperlipidemias - complications Infant, Newborn Insulin Insulin resistance Laboratory testing Lipid metabolism Malaysia - epidemiology Male maternal triglyceride neonatal adiposity Neonates Newborn babies Obesity Obesity - epidemiology Observational studies Offspring Pregnancy pre‐gravid BMI Prospective Studies Skinfold thickness Surveys and Questionnaires Triglycerides - blood Malaysia neonatal adiposity gestational weight gain pre-gravid BMI Asian maternal triglyceride
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objective To determine the association between maternal lipaemia and neonatal anthropometrics in Malaysian mother–offspring pairs. Design Prospective observational cohort study. Setting Single tertiary multidisciplinary antenatal clinic in Malaysia. Population A total of 507 mothers: 145 with gestational diabetes mellitus (GDM); 94 who were obese with normal glucose tolerance (NGT) (pre‐gravid body mass index, BMI ≥ 27.5 kg/m2), and 268 who were not obese with NGT. Methods Maternal demographic, anthropometric, and clinical data were collected during an interview/examination using a structured questionnaire. Blood was drawn for insulin, C‐peptide, triglyceride (Tg), and non‐esterified fatty acid (NEFA) during the 75‐g 2‐hour oral glucose tolerance test (OGTT) screening, and again at 36 weeks of gestation. At birth, neonatal anthropometrics were assessed and data such as gestational weight gain (GWG) were extracted from the records. Main outcome measures Macrosomia, large‐for‐gestational‐age (LGA) status, cohort‐specific birthweight (BW), neonatal fat mass (NFM), and sum of skinfold thickness (SSFT) > 90th centile. Results Fasting Tg > 95th centile (3.6 mmol/L) at screening for OGTT was independently associated with LGA (adjusted odds ratio, aOR 10.82, 95% CI 1.26–93.37) after adjustment for maternal glucose, pre‐gravid BMI, and insulin sensitivity. Fasting glucose was independently associated with a birthweight ratio (BWR) of >90th centile (aOR 2.06, 95% CI 1.17–3.64), but not with LGA status, in this well‐treated GDM cohort with pre‐delivery HbA1c of 5.27%. In all, 45% of mothers had a pre‐gravid BMI of <23 kg/m2 and 61% had a pre‐gravid BMI of ≤ 25 kg/m2, yet a GWG of >10 kg was associated with a 4.25‐fold risk (95% CI 1.71–10.53) of BWR > 90th centile. Conclusion Maternal lipaemia and GWG at a low threshold (>10 kg) adversely impact neonatal adiposity in Asian offspring, independent of glucose, insulin resistance and pre‐gravid BMI. These may therefore be important modifiable metabolic targets in pregnancy. Tweetable Maternal lipids are associated with adiposity in Asian babies independently of pre‐gravid BMI, GDM status, and insulin resistance. Tweetable Maternal lipids are associated with adiposity in Asian babies independently of pre‐gravid BMI, GDM status, and insulin resistance.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1470-0328 1471-0528
DOI:	10.1111/1471-0528.16031