Search Results - "Sambrook Smith, Colin P."

An example of designed multiple ligands spanning protein classes: Dual MCH-1R antagonists/DPPIV inhibitors by Gattrell, William T., Sambrook Smith, Colin P., Smith, Alun J.

“…A ligand-based approach to identify potential starting points for a dual MCH-1R antagonist/DPPIV inhibitor medicinal chemistry program was undertaken…”
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Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability by Bali, Ustav, Barba, Oscar, Dawson, Graham, Gattrell, William T., Horswill, James G., Pan, David A., Procter, Martin J., Rasamison, Chrystelle M., Sambrook Smith, Colin P., Taylor-Warne, Amanda, Wong-Kai-In, Philippe

“…A series of potent carboxylic acid DGAT1 inhibitors with high permeability were developed from a virtual screening hit. Strategies were employed to reduce Pgp…”
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Tools, techniques, organisation and culture of the CADD group at Sygnature Discovery by St-Gallay, Steve A., Sambrook-Smith, Colin P.

“…Computer-aided drug design encompasses a wide variety of tools and techniques, and can be implemented with a range of organisational structures and focus in…”
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Thermogravimetry–infrared evolved gas analysis of the anomalous thermal decomposition of thiophene fulgamic acid by Price, Duncan M., Church, Stephen P., Sambrook-Smith, Colin P.

“…Thermogravimetry with evolved gas analysis by infrared spectrometry was used to study the thermal degradation of thiophene fulgamic acid in an inert…”
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