Exploring Mitochondrial Interactions with Pulsed Electromagnetic Fields: An Insightful Inquiry into Strategies for Addressing Neuroinflammation and Oxidative Stress in Diabetic Neuropathy

Exploring Mitochondrial Interactions with Pulsed Electromagnetic Fields: An Insightful Inquiry into Strategies for Addressing Neuroinflammation and Oxidative Stress in Diabetic Neuropathy

Pulsed electromagnetic fields (PEMFs) are recognized for their potential in regenerative medicine, offering a non-invasive avenue for tissue rejuvenation. While prior research has mainly focused on their effects on bone and dermo-epidermal tissues, the impact of PEMFs on nervous tissue, particularly...

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Published in:International journal of molecular sciences Vol. 25; no. 14; p. 7783
Main Authors: Chianese, Diego, Bonora, Massimo, Sambataro, Maria, Sambato, Luisa, Paola, Luca Dalla, Tremoli, Elena, Cappucci, Ilenia Pia, Scatto, Marco, Pinton, Paolo, Picari, Massimo, Ferroni, Letizia, Zavan, Barbara
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 16-07-2024
Subjects:
Antioxidants
Apoptosis
Biosynthesis
Cell cycle
Chemokines
complex magnetic fields
Cytokines
Diabetes
diabetic foot
Diabetic neuropathy
Electromagnetism
Homeostasis
Hyperglycemia
Hypoxia
Inflammation
Kinases
Magnetic fields
MicroRNAs
Nervous system
Nitric oxide
Oxidative stress
Proteins
pulsed electromagnetic fields
reactive oxygen species
Tumor necrosis factor-TNF
wound healing
wound healing
cytokines
pulsed electromagnetic fields
diabetic foot
reactive oxygen species
complex magnetic fields
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Summary:Pulsed electromagnetic fields (PEMFs) are recognized for their potential in regenerative medicine, offering a non-invasive avenue for tissue rejuvenation. While prior research has mainly focused on their effects on bone and dermo-epidermal tissues, the impact of PEMFs on nervous tissue, particularly in the context of neuropathy associated with the diabetic foot, remains relatively unexplored. Addressing this gap, our preliminary in vitro study investigates the effects of complex magnetic fields (CMFs) on glial-like cells derived from mesenchymal cell differentiation, serving as a model for neuropathy of the diabetic foot. Through assessments of cellular proliferation, hemocompatibility, mutagenicity, and mitochondrial membrane potential, we have established the safety profile of the system. Furthermore, the analysis of microRNAs (miRNAs) suggests that CMFs may exert beneficial effects on cell cycle regulation, as evidenced by the upregulation of the miRNAs within the 121, 127, and 142 families, which are known to be associated with mitochondrial function and cell cycle control. This exploration holds promise for potential applications in mitigating neuropathic complications in diabetic foot conditions.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25147783