Search Results - "Sambade, Maria"

MERTK receptor tyrosine kinase is a therapeutic target in melanoma by Schlegel, Jennifer, Sambade, Maria J, Sather, Susan, Moschos, Stergios J, Tan, Aik-Choon, Winges, Amanda, DeRyckere, Deborah, Carson, Craig C, Trembath, Dimitri G, Tentler, John J, Eckhardt, S Gail, Kuan, Pei-Fen, Hamilton, Ronald L, Duncan, Lyn M, Miller, C Ryan, Nikolaishvili-Feinberg, Nana, Midkiff, Bentley R, Liu, Jing, Zhang, Weihe, Yang, Chao, Wang, Xiaodong, Frye, Stephen V, Earp, H Shelton, Shields, Janiel M, Graham, Douglas K

“…Metastatic melanoma is one of the most aggressive forms of cutaneous cancers. Although recent therapeutic advances have prolonged patient survival, the…”
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Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032 by Sambade, Maria J, Peters, Eldon C, Thomas, Nancy E, Kaufmann, William K, Kimple, Randall J, Shields, Janiel M

“…Abstract Purpose To assess the relative radiosensitivities of a large collection of melanoma cell lines and to determine whether pharmacologic inhibition of…”
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LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases by Van Swearingen, Amanda E. D., Siegel, Marni B., Deal, Allison M., Sambade, Maria J., Hoyle, Alan, Hayes, D. Neil, Jo, Heejoon, Little, Paul, Dees, Elizabeth Claire, Muss, Hyman, Jolly, Trevor, Zagar, Timothy M., Patel, Nirali, Miller, C. Ryan, Parker, Joel S., Smith, J. Keith, Fisher, Julie, Shah, Nikita, Nabell, Lisle, Nanda, Rita, Dillon, Patrick, Abramson, Vandana, Carey, Lisa A., Anders, Carey K.

“…Purpose HER2 + breast cancer (BC) is an aggressive subtype with high rates of brain metastases (BCBM). Two-thirds of HER2 + BCBM demonstrate activation of the…”
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Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer by Karginova, Olga, Siegel, Marni B, Van Swearingen, Amanda E D, Deal, Allison M, Adamo, Barbara, Sambade, Maria J, Bazyar, Soha, Nikolaishvili-Feinberg, Nana, Bash, Ryan, O'Neal, Sara, Sandison, Katie, Parker, Joel S, Santos, Charlene, Darr, David, Zamboni, William, Lee, Yueh Z, Miller, C Ryan, Anders, Carey K

“…Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple-negative breast cancer (TNBC)…”
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Examination and prognostic implications of the unique microenvironment of breast cancer brain metastases by Sambade, Maria J., Prince, Grace, Deal, Allison M., Trembath, Dimitri, McKee, Megan, Garrett, Amy, Keith, Kevin, Ramirez, Juanita, Midkiff, Bentley, Blackwell, Kimberly, Sammons, Sarah, Leone, Jose Pablo, Brufsky, Adam, Morikawa, Aki, Brogi, Edi, Seidman, Andrew, Ewend, Matthew, Carey, Lisa A., Moschos, Stergios J., Hamilton, Ronald L., Vincent, Benjamin, Anders, Carey

“…Purpose Brain metastases (BM) are a complication of advanced breast cancer (BC). Histology of melanoma BM offers prognostic value; however, understanding the…”
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Landscape and selection of vaccine epitopes in SARS-CoV-2 by Smith, Christof C, Olsen, Kelly S, Gentry, Kaylee M, Sambade, Maria, Beck, Wolfgang, Garness, Jason, Entwistle, Sarah, Willis, Caryn, Vensko, Steven, Woods, Allison, Fini, Misha, Carpenter, Brandon, Routh, Eric, Kodysh, Julia, O'Donnell, Timothy, Haber, Carsten, Heiss, Kirsten, Stadler, Volker, Garrison, Erik, Sandor, Adam M, Ting, Jenny P Y, Weiss, Jared, Krajewski, Krzysztof, Grant, Oliver C, Woods, Robert J, Heise, Mark, Vincent, Benjamin G, Rubinsteyn, Alex

“…Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4 T cell, and CD8 T cell…”
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Comprehensive Analysis of the Immunogenomics of Triple-Negative Breast Cancer Brain Metastases From LCCC1419 by Routh, Eric D., Van Swearingen, Amanda E. D., Sambade, Maria J., Vensko, Steven, McClure, Marni B., Woodcock, Mark G., Chai, Shengjie, Cuaboy, Luz A., Wheless, Amy, Garrett, Amy, Carey, Lisa A., Hoyle, Alan P., Parker, Joel S., Vincent, Benjamin G., Anders, Carey K.

“…Background Triple negative breast cancer (TNBC) is an aggressive variant of breast cancer that lacks the expression of estrogen and progesterone receptors (ER…”
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Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer by Van Swearingen, Amanda E D, Sambade, Maria J, Siegel, Marni B, Sud, Shivani, McNeill, Robert S, Bevill, Samantha M, Chen, Xin, Bash, Ryan E, Mounsey, Louisa, Golitz, Brian T, Santos, Charlene, Deal, Allison, Parker, Joel S, Rashid, Naim, Miller, C Ryan, Johnson, Gary L, Anders, Carey K

“…Triple-negative breast cancer (TNBC), lacking expression of hormone and human epidermal growth factor receptor 2 receptors, is an aggressive subtype that…”
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848 Predictions of endogenous neoantigens from varied genomic sources in a syngeneic murine cancer model by Beckabir, Wolfgang, Fini, Misha, Vensko, Steven, Alley, Jessica, Sambade, Maria, Truong, Andrew, Zhou, Mi, Kim, William, Vincent, Benjamin

“…BackgroundCurrent immune checkpoint inhibitor immunotherapy relies on the presence of a pool of pre-existing neoantigen-specific T cells that can be…”
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Evaluating the efficacy of a priming dose of cyclophosphamide prior to pembrolizumab to treat metastatic triple negative breast cancer by Anders, Carey K, Woodcock, Mark G, Van Swearingen, Amanda E D, Moore, Dominic T, Sambade, Maria J, Laurie, Sonia, Robeson, Alexander, Kolupaev, Oleg, Cuaboy, Luz A, Garrett, Amy L, McKinnon, Karen, Cowens, Kristen, Bortone, Dante, Calhoun, Benjamin C, Wilkinson, Alec D, Carey, Lisa, Jolly, Trevor, Muss, Hyman, Reeder-Hayes, Katherine, Kaltman, Rebecca, Jankowitz, Rachel, Gudena, Vinay, Olajide, Oludamilola, Perou, Charles, Dees, E Claire, Vincent, Benjamin G, Serody, Jonathan S

“…PurposeTriple negative breast cancer (TNBC) is characterized by the presence of immune cells in the tumor microenvironment, however, the response to…”
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Lapatinib in Combination With Radiation Diminishes Tumor Regrowth in HER2+ and Basal-Like/EGFR+ Breast Tumor Xenografts by Sambade, Maria J., Ph.D, Kimple, Randall J., M.D., Ph.D, Camp, J. Terese, B.S, Peters, Eldon, B.S, Livasy, Chad A., M.D, Sartor, Carolyn I., M.D, Shields, Janiel M., Ph.D

“…Purpose To determine whether lapatinib, a dual epidermal growth factor receptor (EGFR)/HER2 kinase inhibitor, can radiosensitize EGFR+ or HER2+ breast cancer…”
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Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf > MEK > ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK by Sambade, Maria J, Camp, J. Terese, Kimple, Randall J, Sartor, Carolyn I, Shields, Janiel M

“…Abstract Background and purpose We recently showed that lapatinib, an EGFR/HER2 inhibitor, radiosensitized breast cancer cells of the basal and HER2+ subtypes…”
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Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma by Jeck, William R., Parker, Joel, Carson, Craig C., Shields, Janiel M., Sambade, Maria J., Peters, Eldon C., Burd, Christin E., Thomas, Nancy E., Chiang, Derek Y., Liu, Wenjin, Eberhard, David A., Ollila, David, Grilley-Olson, Juneko, Moschos, Stergios, Neil Hayes, D., Sharpless, Norman E.

“…Summary Somatic sequencing of cancers has produced new insight into tumorigenesis, tumor heterogeneity, and disease progression, but the vast majority of…”
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Repair of Thalassemic Human β -globin mRNA in Mammalian Cells by Antisense Oligonucleotides by Sierakowska, Halina, Sambade, Maria J., Agrawal, Sudhir, Kole, Ryszard

“…In one form of β -thalassemia, a genetic blood disorder, a mutation in intron 2 of the β -globin gene (IVS2-654) causes aberrant splicing of β -globin pre-mRNA…”
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Efficacy and pharmacodynamics of niraparib in BRCA-mutant and wild-type intracranial triple-negative breast cancer murine models by Sambade, Maria J, Van Swearingen, Amanda E D, McClure, Marni B, Deal, Allison M, Santos, Charlene, Sun, Kaiming, Wang, Jing, Mikule, Keith, Anders, Carey K

“…Despite the poor prognosis of triple-negative breast cancer (TNBC) brain metastases, there are no approved systemic therapies. We explored the DNA-damaging…”
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Mechanisms of chromosomal instability in melanoma by Kaufmann, William K., Carson, Craig C., Omolo, Bernard, Filgo, Adam J., Sambade, Maria J., Simpson, Dennis A., Shields, Janiel M., Ibrahim, Joseph G., Thomas, Nancy E.

“…A systems biology approach was applied to investigate the mechanisms of chromosomal instability in melanoma cell lines. Chromosomal instability was quantified…”
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A Genomic Screen for Yeast Vacuolar Membrane ATPase Mutants by Sambade, Maria, Alba, Mercedes, Smardon, Anne M, West, Robert W, Kane, Patricia M

“…V-ATPases acidify multiple organelles, and yeast mutants lacking V-ATPase activity exhibit a distinctive set of growth defects. To better understand the…”
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A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines by Carson, Craig, Omolo, Bernard, Chu, Haitao, Zhou, Yingchun, Sambade, Maria J., Peters, Eldon C., Tompkins, Patrick, Simpson, Dennis A., Thomas, Nancy E., Fan, Cheng, Sarasin, Alain, Dessen, Philippe, Shields, Janiel M., Ibrahim, Joseph G., Kaufmann, William K.

“…Summary Melanoma cell lines and normal human melanocytes (NHM) were assayed for p53‐dependent G1 checkpoint response to ionizing radiation (IR)‐induced DNA…”
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The Yeast Vacuolar Proton-translocating ATPase Contains a Subunit Homologous to the Manduca sexta and Bovine e Subunits That Is Essential for Function by Sambade, Maria, Kane, Patricia M.

“…The yeast cwh36Δ mutant was identified in a screen for yeast mutants exhibiting a Vma- phenotype suggestive of loss of vacuolar proton-translocating ATPase…”
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478 Translation of a therapeutic neoantigen vaccine workflow to SARS-CoV-2 vaccine development by Smith, Christof, Entwistle, Sarah, Willis, Caryn, Vensko, Steven, Beck, Wolfgang, Garness, Jason, Sambade, Maria, Routh, Eric, Olsen, Kelly, Carpenter, Brandon, Gentry, Kaylee, Fadri, Maria, Fini, Misha, Washington, Amber, Kodysh, Julia, O’Donnell, Timothy, Haber, Carsten, Heiss, Kirsten, Stadler, Volker, Garrison, Erik, Grant, Oliver, Woods, Robert, Heise, Mark, Vincent, Benjamin, Rubinsteyn, Alexander

“…BackgroundThere is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for…”
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