Search Results - "Samayoa, Josue"

LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates by Purcell, James W, Tanlimco, Sonia G, Hickson, Jonathan, Fox, Melvin, Sho, Mien, Durkin, Lisa, Uziel, Tamar, Powers, Rick, Foster, Kelly, McGonigal, Thomas, Kumar, Subashri, Samayoa, Josue, Zhang, Dong, Palma, Joann P, Mishra, Sasmita, Hollenbaugh, Diane, Gish, Kurt, Morgan-Lappe, Susan E, Hsi, Eric D, Chao, Debra T

“…Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with…”
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Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA) by Danaher, Patrick, Warren, Sarah, Lu, Rongze, Samayoa, Josue, Sullivan, Amy, Pekker, Irena, Wallden, Brett, Marincola, Francesco M, Cesano, Alessandra

“…The Tumor Inflammation Signature (TIS) is an investigational use only (IUO) 18-gene signature that measures a pre-existing but suppressed adaptive immune…”
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Genetic Landscape of the Childhood Cancer Medulloblastoma by Parsons, D. Williams, Li, Meng, Zhang, Xiaosong, Jones, Siân, Leary, Rebecca J, Lin, Jimmy Cheng-Ho, Boca, Simina M, Carter, Hannah, Samayoa, Josue, Bettegowda, Chetan, Gallia, Gary L, Jallo, George I, Binder, Zev A, Nikolsky, Yuri, Hartigan, James, Smith, Doug R, Gerhard, Daniela S, Fults, Daniel W, VandenBerg, Scott, Berger, Mitchel S, Marie, Suely Kazue Nagahashi, Shinjo, Sueli Mieko Oba, Clara, Carlos, Phillips, Peter C, Minturn, Jane E, Biegel, Jaclyn A, Judkins, Alexander R, Resnick, Adam C, Storm, Phillip B, Curran, Tom, He, Yiping, Rasheed, B. Ahmed, Friedman, Henry S, Keir, Stephen T, McLendon, Roger, Northcott, Paul A, Taylor, Michael D, Burger, Peter C, Riggins, Gregory J, Karchin, Rachel, Parmigiani, Giovanni, Bigner, Darell D, Yan, Hai, Papadopoulos, Nick, Vogelstein, Bert, Kinzler, Kenneth W, Velculescu, Victor E

“…Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number…”
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A balance score between immune stimulatory and suppressive microenvironments identifies mediators of tumour immunity and predicts pan-cancer survival by Turan, Tolga, Kongpachith, Sarah, Halliwill, Kyle, Roelands, Jessica, Hendrickx, Wouter, Marincola, Francesco M., Hudson, Thomas J., Jacob, Howard J., Bedognetti, Davide, Samayoa, Josue, Ceccarelli, Michele

“…Background The balance between immune-stimulatory and immune-suppressive mechanisms in the tumour microenvironment is associated with tumour rejection and can…”
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Correction: A balance score between immune stimulatory and suppressive microenvironments identifies mediators of tumour immunity and predicts pan-cancer survival by Turan, Tolga, Kongpachith, Sarah, Halliwill, Kyle, Roelands, Jessica, Hendrickx, Wouter, Marincola, Francesco M., Hudson, Thomas J., Jacob, Howard J., Bedognetti, Davide, Samayoa, Josue, Ceccarelli, Michele

“…A Correction to this paper has been published: https://doi.org/10.1038/s41416-020-01193-w…”
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Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM) by Carter, Hannah, Samayoa, Josue, Hruban, Ralph H., Karchin, Rachel

“…Over 20,000 genes were recently sequenced in a series of 24 pancreatic cancers. We applied CHASM (Cancer-specific High-throughput Annotation of Somatic…”
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Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response by Roelands, Jessica, Hendrickx, Wouter, Zoppoli, Gabriele, Mall, Raghvendra, Saad, Mohamad, Halliwill, Kyle, Curigliano, Giuseppe, Rinchai, Darawan, Decock, Julie, Delogu, Lucia G, Turan, Tolga, Samayoa, Josue, Chouchane, Lotfi, Ballestrero, Alberto, Wang, Ena, Finetti, Pascal, Bertucci, Francois, Miller, Lance D, Galon, Jerome, Marincola, Francesco M, Kuppen, Peter J K, Ceccarelli, Michele, Bedognetti, Davide

“…BackgroundAn immune active cancer phenotype typified by a T helper 1 (Th-1) immune response has been associated with increased responsiveness to immunotherapy…”
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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop by Bedognetti, Davide, Ceccarelli, Michele, Galluzzi, Lorenzo, Lu, Rongze, Palucka, Karolina, Samayoa, Josue, Spranger, Stefani, Warren, Sarah, Wong, Kwok-Kin, Ziv, Elad, Chowell, Diego, Coussens, Lisa M, De Carvalho, Daniel D, DeNardo, David G, Galon, Jérôme, Kaufman, Howard L, Kirchhoff, Tomas, Lotze, Michael T, Luke, Jason J, Minn, Andy J, Politi, Katerina, Shultz, Leonard D, Simon, Richard, Thórsson, Vésteinn, Weidhaas, Joanne B, Ascierto, Maria Libera, Ascierto, Paolo Antonio, Barnes, James M, Barsan, Valentin, Bommareddy, Praveen K, Bot, Adrian, Church, Sarah E, Ciliberto, Gennaro, De Maria, Andrea, Draganov, Dobrin, Ho, Winson S, McGee, Heather M, Monette, Anne, Murphy, Joseph F, Nisticò, Paola, Park, Wungki, Patel, Maulik, Quigley, Michael, Radvanyi, Laszlo, Raftopoulos, Harry, Rudqvist, Nils-Petter, Snyder, Alexandra, Sweis, Randy F, Valpione, Sara, Zappasodi, Roberta, Butterfield, Lisa H, Disis, Mary L, Fox, Bernard A, Cesano, Alessandra, Marincola, Francesco M

“…Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a…”
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Immune oncology, immune responsiveness and the theory of everything by Turan, Tolga, Kannan, Deepti, Patel, Maulik, Matthew Barnes, J, Tanlimco, Sonia G, Lu, Rongze, Halliwill, Kyle, Kongpachith, Sarah, Kline, Douglas E, Hendrickx, Wouter, Cesano, Alessandra, Butterfield, Lisa H, Kaufman, Howard L, Hudson, Thomas J, Bedognetti, Davide, Marincola, Francesco, Samayoa, Josue

“…Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent…”
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Murinization and H Chain Isotype Matching of the Anti-GITR Antibody DTA-1 Reduces Immunogenicity-Mediated Anaphylaxis in C57BL/6 Mice by Belmar, Nicole A, Chan, Sarah W, Fox, Melvin I, Samayoa, Josue A, Stickler, Marcia M, Tran, Ninian N, Akamatsu, Yoshiko, Hollenbaugh, Diane, Harding, Fiona A, Alvarez, Hamsell M

“…Recent advances in immuno-oncology have shown that the immune system can be activated to induce long-term, durable antitumor responses. For immuno-oncology…”
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Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development by Berzofsky, Jay A, Koch, Lauren Gerard, Britton, Steven L, Chen, Shaochen, Zhu, Wei, Ma, Xuanyi, Comuzzie, Anthony G, Devy-Dimanche, Laetitia, Feaver, Ryan, Grimm, Jan, Hock, Christoph, Nitsch, Roger M, Hoying, James B, Lusis, Aldons J, Marincola, Francesco, Samayoa, Josue, Turan, Tolga, Pearce, David A, Nurmi, Antti, Huhtala, Tuulia, Shatillo, Artem, Puoliväli, Jukka, Heikkinen, Taneli, Bragge, Timo, Lehtimäki, Kimmo, Sanyal, Arun J, Strange, Kevin, Taylor, D. Lansing, Miedel, Mark, Jia, Shanhang, Soto-Guterriez, Alex, Stern, Andrew, Gough, Albert

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Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop by Bedognetti, Davide, Ceccarelli, Michele, Galluzzi, Lorenzo, Lu, Rongze, Palucka, Karolina, Samayoa, Josue, Spranger, Stefani, Warren, Sarah, Wong, Kwok-Kin, Ziv, Elad, Chowell, Diego, Coussens, Lisa M, De Carvalho, Daniel D, DeNardo, David G, Galon, Jérôme, Kaufman, Howard L, Kirchhoff, Tomas, Lotze, Michael T, Luke, Jason J, Minn, Andy J, Politi, Katerina, Shultz, Leonard D, Simon, Richard, Thórsson, Vésteinn, Weidhaas, Joanne B, Ascierto, Maria Libera, Ascierto, Paolo Antonio, Barnes, James M, Barsan, Valentin, Bommareddy, Praveen K, Bot, Adrian, Church, Sarah E, Ciliberto, Gennaro, De Maria, Andrea, Draganov, Dobrin, Ho, Winson S, McGee, Heather M, Monette, Anne, Murphy, Joseph F, Nisticò, Paola, Park, Wungki, Patel, Maulik, Quigley, Michael, Radvanyi, Laszlo, Raftopoulos, Harry, Rudqvist, Nils-Petter, Snyder, Alexandra, Sweis, Randy F, Valpione, Sara, Zappasodi, Roberta, Butterfield, Lisa H, Disis, Mary L, Fox, Bernard A, Cesano, Alessandra, Marincola, Francesco M

“…Following publication of the original article [1], the author reported that an author name, Roberta Zappasodi, was missed in the authorship list…”
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The STEMI reperfusion status in Guatemala: An unanswered question by Gil-Salazar, Mariana, Ramos-Castro, Magda I, Samayoa-Ruano, Josué F, Anleu-De León, Elisa M, Overall-Salazar, Paola, Cornejo-Guerra, José A

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Genomic analysis and prediction of therapeutic vulnerabilities of small cell lung cancer from rovalpituzumab tesirine phase III trial (MERU) by Zhao, Weilong, McLaughlin, Robert Tyler, Masica, David, Huntzicker, Erik, Uziel, Tamar, Flister, Michael, Bankovich, Alex, Samayoa, Josue, French, Dorothy, Zhao, Xi

“…8577 Background: Predicting variable therapeutic responses that are driven by the genetic and transcriptomic heterogeneity of Small Cell Lung Cancer (SCLC)…”
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Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity by Ho, Sun K, Xu, Zhenghai, Thakur, Archana, Fox, Melvin, Tan, Siu Sze, DiGiammarino, Enrico, Zhou, Li, Sho, Mien, Cairns, Belinda, Zhao, Vivian, Xiong, Mengli, Samayoa, Josue, Forsyth, Charles M, Powers, David B, Chao, Debra T, Hollenbaugh, Diane, Alvarez, Hamsell M, Akamatsu, Yoshiko

“…CD137 (TNFRSF9, 4-1BB) agonist antibodies (mAb) have demonstrated potent antitumor activity with memory response while causing hepatotoxicity in mouse models…”
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Identification of prokaryotic small proteins using a comparative genomic approach by Samayoa, Josue, Yildiz, Fitnat H., Karplus, Kevin

“…Motivation: Accurate prediction of genes encoding small proteins (on the order of 50 amino acids or less) remains an elusive open problem in bioinformatics…”
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Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-L1 treatment by Laubach, Kyra, Turan, Tolga, Mathew, Rebecca, Wilsbacher, Julie, Engelhardt, John, Samayoa, Josue

“…The development of immune checkpoint blockade (ICB) therapies has been instrumental in advancing the field of immunotherapy. Despite the prominence of these…”
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CTLA4-Ig-Based Bifunctional Costimulation Inhibitor Blocks CD28 and ICOS Signaling to Prevent T Cell Priming and Effector Function by Goenka, Radhika, Xu, Zhenghai, Samayoa, Josue, Banach, David, Beam, Christine, Bose, Sahana, Dooner, Gerri, Forsyth, Charles M, Lu, Xiaoqing, Medina, Limary, Sadhukhan, Ramkrishna, Sielaff, Bernhard, Sousa, Silvino, Tao, Qingfeng, Touw, Debra, Wu, Fei, Kingsbury, Gillian A, Akamatsu, Yoshiko

“…CTLA4-Ig/abatacept dampens activation of naive T cells by blocking costimulation via CD28. It is an approved drug for rheumatoid arthritis but failed to…”
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Abstract 2551: Harness the power of real-world-data for oncology target and biomarker research: A case study by applying clinic-genomics data for 2,659 lung cancer patients and beyond by Wu, Si, Zhao, Weilong, Choi, Christy, Cai, Mona, Ansell, Peter, Liede, Alexander, Chen, Rong, Zhao, Xi, Samayoa, Josue

“…Abstract Randomized controlled trials (RCTs) are the gold standard for evaluating drug safety and efficacy in controlled settings, but they have limited…”
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iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type-Specific Markers of Immune-Cell Infiltration by Turan, Tolga, Kongpachith, Sarah, Halliwill, Kyle, McLaughlin, Robert T, Binnewies, Mikhail, Reddy, Dhemath, Zhao, Xi, Mathew, Rebecca, Ye, Shiming, Jacob, Howard J, Samayoa, Josue

“…The development of immune checkpoint-based immunotherapies has been a major advancement in the treatment of cancer, with a subset of patients exhibiting…”
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