Search Results - "Samarut, Éric"

Zebrafish Is a Powerful Tool for Precision Medicine Approaches to Neurological Disorders by Ochenkowska, Katarzyna, Herold, Aveeva, Samarut, Éric

“…Personalized medicine is currently one of the most promising tools which give hope to patients with no suitable or no available treatment. Patient-specific…”
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A simplified method for identifying early CRISPR-induced indels in zebrafish embryos using High Resolution Melting analysis by Samarut, Éric, Lissouba, Alexandra, Drapeau, Pierre

“…The CRISPR/Cas9 system has become a regularly used tool for editing the genome of many model organisms at specific sites. However, two limiting steps arise in…”
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Epileptic Seizures: Glia–Neuron Interactions For Better or For Worse by Rosch, Richard E., Samarut, Éric

“…Investigations of the mechanisms generating epileptic seizures have primarily focused on neurons. However, more systemic research of brain circuits has…”
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Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development by Samarut, Eric, Rochette-Egly, Cécile

“…The vitamin A derivative, retinoic acid (RA), is essential for embryonic development through the activation of cognate nuclear receptors, RARs, which work as…”
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Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models by Choo, Brandon Kar Meng, Kundap, Uday Praful, Faudzi, Siti Munirah Mohd, Abas, Faridah, Shaikh, Mohd. Farooq, Samarut, Éric

“…Seizures are the outward manifestation of abnormally excessive or synchronous brain activity. While seizures can be somewhat symptomatically managed with…”
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γ‐Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment by Samarut, Éric, Swaminathan, Amrutha, Riché, Raphaëlle, Liao, Meijiang, Hassan‐Abdi, Rahma, Renault, Solène, Allard, Marc, Dufour, Liselotte, Cossette, Patrick, Soussi‐Yanicostas, Nadia, Drapeau, Pierre

“…Summary Objective In humans, mutations of the γ‐aminobutyric acid receptor subunit 1 (GABRA1) cause either mild or severe generalized epilepsy. Although these…”
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Single and Synergistic Effects of Cannabidiol and Δ-9-Tetrahydrocannabinol on Zebrafish Models of Neuro-Hyperactivity by Samarut, Éric, Nixon, Jessica, Kundap, Uday P, Drapeau, Pierre, Ellis, Lee D

“…In this study, we aimed to investigate the effect of the two main active cannabinoids extracted from cannabis: Δ-9-tetrahydrocannabinol (THC) and cannabidiol…”
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Targeted knockout of GABA-A receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae by Liao, Meijiang, Kundap, Uday, Rosch, Richard E, Burrows, Dominic R W, Meyer, Martin P, Ouled Amar Bencheikh, Bouchra, Cossette, Patrick, Samarut, Éric

“…Epilepsy is a common primary neurological disorder characterized by the chronic tendency of a patient to experience epileptic seizures, which are abnormal body…”
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ZebRA: An overview of retinoic acid signaling during zebrafish development by Samarut, Eric, Fraher, Daniel, Laudet, Vincent, Gibert, Yann

“…Retinoic acid (RA), the main active vitamin A derivative, is crucial for embryo development, regulating cellular processes, embryo patterning and…”
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Usage of Genetic Panels in an Adult Epilepsy Clinic by Li, Jimmy, Toffa, Dènahin Hinnoutondji, Lefèbvre, Maude, Tétreault, Martine, Cossette, Patrick, Samarut, Éric, Nguyen, Dang Khoa

“…There is limited data on the utility, yield, and cost efficiency of genetic testing in adults with epilepsy. We aimed to describe the yield and utility of…”
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Novel NALCN variant linked to temporal lobe epilepsy by Nguyen, Emmanuelle, Tétreault, Martine, Toffa, Dènahin Hinnoutondji, Cossette, Patrick, Samarut, Éric, Nguyen, Dang Khoa

“…The sodium leak channel (NALCN) gene encodes a sodium leak channel that plays an important role in the regulation of the resting membrane potential and the…”
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Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development by Swaminathan, Amrutha, Hassan-Abdi, Rahma, Renault, Solène, Siekierska, Aleksandra, Riché, Raphaëlle, Liao, Meijiang, de Witte, Peter A.M., Yanicostas, Constantin, Soussi-Yanicostas, Nadia, Drapeau, Pierre, Samarut, Éric

“…Mutations in DEPDC5 are causal factors for a broad spectrum of focal epilepsies, but the underlying pathogenic mechanisms are still largely unknown. To address…”
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Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish by Samarut, Eric, Chalopin, Domitille, Riché, Raphaëlle, Allard, Marc, Liao, Meijiang, Drapeau, Pierre

“…Glycine receptors (GlyRs) are ligand-gated chloride channels mediating inhibitory neurotransmission in the brain stem and spinal cord. They function as…”
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Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome by Efthymiou, Stephanie, Scala, Marcello, Nagaraj, Vini, Ochenkowska, Katarzyna, Komdeur, Fenne L, Liang, Robin A, Abdel-Hamid, Mohamed S, Sultan, Tipu, Barøy, Tuva, Van Ghelue, Marijke, Vona, Barbara, Maroofian, Reza, Zafar, Faisal, Alkuraya, Fowzan S, Zaki, Maha S, Severino, Mariasavina, Duru, Kingsley C, Tryon, Robert C, Brauteset, Lin Vigdis, Ansari, Morad, Hamilton, Mark, van Haelst, Mieke M, van Haaften, Gijs, Zara, Federico, Houlden, Henry, Samarut, Éric, Nichols, Colin G, Smeland, Marie F, McClenaghan, Conor

“…Loss-of-function mutation of ABCC9, the gene encoding the SUR2 subunit of ATP sensitive-potassium (KATP) channels, was recently associated with autosomal…”
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Functional Genomics of Epilepsy and Associated Neurodevelopmental Disorders Using Simple Animal Models: From Genes, Molecules to Brain Networks by Rosch, Richard, Burrows, Dominic R W, Jones, Laura B, Peters, Colin H, Ruben, Peter, Samarut, Éric

“…The genetic diagnosis of patients with seizure disorders has been improved significantly by the development of affordable next-generation sequencing…”
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X-Linked Bilateral Polymicrogyria With Epilepsy and Intellectual Disability Associated With a Novel KIF4A Variant by Laflamme, Naomi, Triassi, Valérie, Martineau, Laurence, Toffa, Dènahin Hinnoutondji, Létourneau-Guillon, Laurent, Laplante, Annie, Cossette, Patrick, Samarut, Éric, Tétreault, Martine, Nguyen, Dang Khoa

“…We studied three brothers and a maternal half-brother featuring global developmental delay, mild to moderate intellectual disability, epilepsy, microcephaly,…”
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Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish by Heylen, Lise, Pham, Duc-Hung, De Meulemeester, Ann-Sofie, Samarut, Éric, Skiba, Adrianna, Copmans, Daniëlle, Kazwiny, Youcef, Vanden Berghe, Pieter, de Witte, Peter A. M., Siekierska, Aleksandra

“…Epilepsy is a common disorder of the brain characterized by spontaneous recurrent seizures, which develop gradually during a process called epileptogenesis…”
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Zebrafish Ride the Danube's Wave for the 10th European Zebrafish Meeting by Samarut, Éric, Dona, Margo, Yoganantharjah, Prusothman

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A comprehensive assessment of palmatine as anticonvulsant agent – In vivo and in silico studies by Nieoczym, Dorota, Marszalek-Grabska, Marta, Szalak, Radoslaw, Kundap, Uday, Kaczor, Agnieszka A., Wrobel, Tomasz M., Kosheva, Nataliia, Komar, Malgorzata, Abram, Michal, Esguerra, Camila V., Samarut, Eric, Pieróg, Mateusz, Jakubiec, Marcin, Kaminski, Krzysztof, Kukula-Koch, Wirginia, Gawel, Kinga

“…Previously, we demonstrated that palmatine (PALM) – an isoquinoline alkaloid from Berberis sibrica radix, exerted antiseizure activity in the…”
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Genome-wide in Silico Identification of New Conserved and Functional Retinoic Acid Receptor Response Elements (Direct Repeats Separated by 5 bp) by Lalevée, Sébastien, Anno, Yannick N., Chatagnon, Amandine, Samarut, Eric, Poch, Olivier, Laudet, Vincent, Benoit, Gerard, Lecompte, Odile, Rochette-Egly, Cécile

“…The nuclear retinoic acid receptors interact with specific retinoic acid (RA) response elements (RAREs) located in the promoters of target genes to orchestrate…”
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