Search Results - "Samarpita, Snigdha"

Leveraging Exosomes as the Next-Generation Bio-Shuttles: The Next Biggest Approach against Th17 Cell Catastrophe by Samarpita, Snigdha, Li, Xiaogang

“…In recent years, the launch of clinical-grade exosomes is rising expeditiously, as they represent a new powerful approach for the delivery of advanced…”
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Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug by Samarpita, Snigdha, Kim, Joo Young, Rasool, Mahaboob Khan, Kim, Kyoung Soo

“…Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid…”
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Majoon Chobchini attenuates arthritis disease severity and RANKL-mediated osteoclastogenesis in rheumatoid arthritis by Samarpita, Snigdha, Doss, Hari Madhuri, Ganesan, Ramamoorthi, Rasool, Mahaboobkhan

“…Majoon Chobchini, a polyherbal Unani compound, has been used holistically in India to treat rheumatoid arthritis. However, the potential mechanism underlying…”
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Selective blockade of IL-21 by myricetin impedes T follicular helper cell differentiation by negatively regulating the JAK/STAT/Bcl-6 pathway in a rheumatoid arthritis animal model by Jose, Ann Miriam, Samarpita, Snigdha, Panchal, Nagesh Kishan, Sabina, Evan Prince, Rasool, Mahaboobkhan

“…Interleukin (IL)-21 is a major lineage-defining factor that promotes Tfh cell differentiation. The current study investigated the molecular basis of myricetin,…”
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Majoon chobchini reinstates PDL-1 expression and blocks dendritic cell -T helper 17 pathogenic axis in rheumatoid arthritis animal model by Samarpita, Snigdha, Rasool, Mahaboobkhan

“…Dendritic cells (DCs) are the critical players in the puzzle of rheumatoid arthritis (RA) disease pathogenesis. Blockade of DC activation has been shown to…”
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Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis by Samarpita, Snigdha, Rasool, Mahaboobkhan

“…•Cyanidin, a potent inhibitor of IL-17 signaling associated pathogenesis in RA.•Cyanidin modulates IL-17A/IL-17RA interaction.•Cyanidin blocks IL-17A/p38 MAPK…”
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Cyanidin restores Th17/Treg balance and inhibits T follicular helper cell differentiation via modulation of ROCK2 signaling in an experimental model of rheumatoid arthritis by Samarpita, Snigdha, Rasool, Mahaboobkhan

“…•Cyanidin regulates Th17/Treg ratio and Tfh cell differentiation in RA.•Cyanidin reduced Tfh cell proportion and IgG levels in AIA rats.•Cyanidin upregulates…”
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Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis by Samarpita, Snigdha, Ganesan, Ramamoorthi, Rasool, Mahaboobkhan

“…The hyperplastic phenotype of fibroblast-like synoviocytes (FLSs) plays an important role for synovitis, chronic inflammation and joint destruction in…”
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Unleashing the pathological imprinting of cancer in autoimmunity: Is ZEB1 the answer? by Rithvik, Arulkumaran, Samarpita, Snigdha, Rasool, Mahaboobkhan

“…The intriguing scientific relationship between autoimmunity and cancer immunology have been traditionally indulged to throw spotlight on novel pathological…”
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Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-κB signalling pathway by Doss, Hari Madhuri, Samarpita, Snigdha, Ganesan, Ramamoorthi, Rasool, Mahaboobkhan

“…Bone erosion induced by enhanced osteoclast formation is a debilitating pathological phenomenon in rheumatoid arthritis (RA). Recent finding has revealed that…”
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Interleukin 17 under hypoxia mimetic condition augments osteoclast mediated bone erosion and expression of HIF-1α and MMP-9 by Samarpita, Snigdha, Doss, Hari Madhuri, Ganesan, Ramamoorthi, Rasool, Mahaboobkhan

“…•IL-17 and hypoxia promotes osteoclast mediated bone resorption in vitro.•IL-17 synergise with hypoxia to augment the expression of HIF-1α, MMP-9 and…”
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CYT387 Inhibits the Hyperproliferative Potential of Fibroblast-like Synoviocytes via Modulation of IL-6/JAK1/STAT3 Signaling in Rheumatoid Arthritis by Srivastava, Susmita, Samarpita, Snigdha, Ganesan, Ramamoorthi, Rasool, Mahaboobkhan

“…Fibroblast-like synoviocytes (FLS) are the critical effector cells primarily involved in rheumatoid arthritis (RA) disease pathogenesis. Interleukin (IL)-6, a…”
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Therapeutic Blocking of IL-17A Binding to IL-17RA Diminishes PD-L1 Expression Is a Novel Therapeutic Approach for ADPKD: TH-PO409 by Samarpita, Snigdha, Li, Xiaoyan, Agborbesong, Ewud, Zhou, Xia, Torres, Vicente E., Li, Xiaogang

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IL-17A/IL-17RA interaction blockade sensitizes synovial macrophages to efferocytosis and PD-L1 signaling via rewiring STAT-3/ADAM17/MERTK axis in rheumatoid arthritis animal model by Samarpita, Snigdha, Srivastava, Susmita, Srikanth, Manupati, Miriam Jose, Ann, Rithvik, Arulkumaran, Rasool, Mahaboobkhan

“…•Disruption of IL-17A interaction with IL-17RA restored efferocytosis in an adjuvant model of RA.•IL-17A suppressed efferocytosis via ADAM17 mediated cleavage…”
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Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-?B signalling pathway by Doss, Hari Madhuri, Samarpita, Snigdha, Ganesan, Ramamoorthi, Rasool, Mahaboobkhan

“…Aims Bone erosion induced by enhanced osteoclast formation is a debilitating pathological phenomenon in rheumatoid arthritis (RA). Recent finding has revealed…”
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8-Shogaol inhibits rheumatoid arthritis through targeting TAK1 by Jo, Seongin, Samarpita, Snigdha, Lee, Ji Su, Lee, Yong Joon, Son, Joe Eun, Jeong, Minju, Kim, Jae Hwan, Hong, Seungpyo, Yoo, Seung-Ah, Kim, Wan-Uk, Rasool, Mahaboobkhan, Byun, Sanguine

“…Rheumatoid arthritis (RA) is a chronic immune-mediated disorder, mainly characterized by synovial inflammation and joint damage. If insufficiently treated, RA…”
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PdCl2-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor by Thirupataiah, B., Mounika, Guntipally, Reddy, Gangireddy Sujeevan, Kumar, Jetta Sandeep, Hossain, Kazi Amirul, Medishetti, Raghavender, Samarpita, Snigdha, Rasool, Mahaboobkhan, Mudgal, Jayesh, Mathew, Jessy E., Shenoy, Gautham G., Rao, C. Mallikarjuna, Chatti, Kiranam, Parsa, Kishore V.L., Pal, Manojit

“…While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor…”
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Targeting next-generation PDE4 inhibitors in search of potential management of rheumatoid arthritis and psoriasis by Bhuktar, Harshavardhan, Thirupataiah, B., Mounika, Guntipally, Samarpita, Snigdha, Rithvik, Arulkumaran, Sasi Priya, S.V.S., Naskar, Roumi, Medishetti, Raghavender, Jagadish, P.C., Parsa, Kishore V.L., Rasool, Mahaboobkhan, Chakraborty, Sandipan, Pal, Manojit

“…The in silico, in vitro and in vivo evaluation of a new class of isoquinolone derivatives afforded compound 1l as the next-generation PDE4 inhibitor that can…”
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Fe(III)-catalyzed regioselective and faster synthesis of isocoumarins with 3-oxoalkyl moiety at C-4: Identification of new inhibitors of PDE4 by Thirupataiah, B., Bhuktar, Harshavardhan, Mounika, Guntipally, Reddy, Gangireddy Sujeevan, Kumar, Jetta Sandeep, Shukla, Sharda, Hossain, Kazi Amirul, Medishetti, Raghavender, Samarpita, Snigdha, Rasool, Mahaboobkhan, Jagadish, P.C., Shenoy, Gautham G., Parsa, Kishore V.L., Pal, Manojit

“…[Display omitted] •The inexpensive FeCl3 afforded regioselective and faster synthesis of isocoumarins.•Isocoumarins with 3-oxoalkyl moiety at C-4 showed potent…”
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PdCl 2 -catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor by Thirupataiah, B, Mounika, Guntipally, Reddy, Gangireddy Sujeevan, Kumar, Jetta Sandeep, Hossain, Kazi Amirul, Medishetti, Raghavender, Samarpita, Snigdha, Rasool, Mahaboobkhan, Mudgal, Jayesh, Mathew, Jessy E, Shenoy, Gautham G, Rao, C Mallikarjuna, Chatti, Kiranam, Parsa, Kishore V L, Pal, Manojit

“…While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor…”
Get full text