Study of Clinical Profile and Antibiotic Sensitivity Pattern in Culture-positive Typhoid Fever Cases

Study of Clinical Profile and Antibiotic Sensitivity Pattern in Culture-positive Typhoid Fever Cases

Salmonella enteric serotype Typhi has created a significant therapeutic problem as these strains have developed resistance to the commonly used antimicrobials for the treatment of typhoid fever. To assess the clinical profile and sensitivity patterns to anti-typhoid drugs. A retrospective analysis o...

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Bibliographic Details
Published in:Indian journal of community medicine Vol. 37; no. 4; pp. 256 - 258
Main Authors: Kumar, Ashwini, Pandit, Vinay, Shetty, Seema, Rao, Chythra R, Pattanshetty, Sanjay, Samarasinghe, Charmaine M
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-10-2012
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects:
Abdomen
Antibiotic sensitivity
Antibiotics
clinical profile
Complications and side effects
Dosage and administration
Drug resistance
Drug therapy
Fever
Health aspects
Patient outcomes
Risk factors
Salmonella
Short Communication
Teaching hospitals
Typhoid
Typhoid fever
India
typhoid fever
Antibiotic sensitivity
clinical profile
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Summary:Salmonella enteric serotype Typhi has created a significant therapeutic problem as these strains have developed resistance to the commonly used antimicrobials for the treatment of typhoid fever. To assess the clinical profile and sensitivity patterns to anti-typhoid drugs. A retrospective analysis of 106 culture-positive typhoid cases admitted in a tertiary care hospital during the years 2005-2008. Records of 106 patients were evaluated, 83 (78.3%) males and 23 (21.7%) females. Fever was present in all patients. Headache in 63 (59.4%) patients and generalized body ache in 53 (32.5%) patients were the most common symptoms, while spleenomegaly in 47 (44.3%) patients and hepatomegaly in 42 (39.6%) patients were the common presenting signs. A maximum sensitivity of 96.6% was observed with cephalosporins, whereas a resistance of 29.2% was seen with fluoroquinolones. A high degree of sensitivity was noted to chloramphenicol, ampicillin and sulphonamides, showing a trend of roll-back of sensitivity to conventional antibiotics.
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ISSN:0970-0218
1998-3581
DOI:10.4103/0970-0218.103475