Search Results - "Samaranch, L"

Axonal transport of adeno-associated viral vectors is serotype-dependent by Salegio, E A, Samaranch, L, Kells, A P, Mittermeyer, G, San Sebastian, W, Zhou, S, Beyer, J, Forsayeth, J, Bankiewicz, K S

“…We have previously shown that adeno-associated virus type 2 (AAV2) undergoes anterograde axonal transport in rat and non-human primate brain. We screened other…”
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Axonal transport of AAV9 in nonhuman primate brain by Green, F, Samaranch, L, Zhang, H S, Manning-Bog, A, Meyer, K, Forsayeth, J, Bankiewicz, K S

“…A pilot study in nonhuman primates was conducted, in which two Rhesus macaques received bilateral parenchymal infusions of adeno-associated virus serotype 9…”
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MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain by Samaranch, L, Blits, B, San Sebastian, W, Hadaczek, P, Bringas, J, Sudhakar, V, Macayan, M, Pivirotto, P J, Petry, H, Bankiewicz, K S

“…The present study was designed to characterize transduction of non-human primate brain and spinal cord with AAV5 viral vector after parenchymal delivery…”
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Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain by San Sebastian, W, Samaranch, L, Heller, G, Kells, A P, Bringas, J, Pivirotto, P, Forsayeth, J, Bankiewicz, K S

“…We recently demonstrated that axonal transport of adeno-associated virus (AAV) is serotype-dependent. Thus, AAV serotype 2 (AAV2) is anterogradely transported…”
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Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response by Samaranch, L, Hadaczek, P, Kells, A P, Bringas, J R, Stockinger, D, San Sebastian, W, Macayan, M, Samineni, S, Pivirotto, P, Forsayeth, J, Bankiewicz, K S

“…Adeno-associated virus serotype 2 (AAV2) has previously been reported to be a slowly uncoating virus in peripheral tissues, but persistence of intact vector in…”
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Memory decline evolves independently of disease activity in MS by Duque, B, Sepulcre, J, Bejarano, B, Samaranch, L, Pastor, P, Villoslada, P

“…Background The natural history of cognitive impairment in multiple sclerosis (MS) and its relationship with disease activity is not well known. In this study,…”
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SPG11 compound mutations in spastic paraparesis with thin corpus callosum by SAMARANCH, L, RIVEROL, M, MASDEU, J. C, LORENZO, E, VIDAL-TABOADA, J. M, IRIGOYEN, J, PASTOR, M. A, DE CASTRO, P, PASTOR, P

“…Autosomal recessive hereditary spastic paraparesis with thin corpus callosum (ARHSP-TCC) is being increasingly recognized as a variety of spastic paraplegia…”
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Forceps Minor Region Signal Abnormality "Ears of the Lynx": An Early MRI Finding in Spastic Paraparesis with Thin Corpus Callosum and Mutations in the Spatacsin Gene (SPG11) on Chromosome 15 by Riverol, M., Samaranch, L., Pascual, B., Pastor, P., Irigoyen, J., Pastor, M.A., De Castro, P., Masdeu, J.C.

“…ABSTRACT BACKGROUND AND PURPOSE A thin corpus callosum on magnetic resonance imaging (MRI) characterizes a type of autosomal recessive disorder with…”
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Lack of interaction of SNCA and MAPT genotypes in Parkinson's disease by Botta-Orfila, T., Ezquerra, M., Ríos, J., Fernández-Santiago, R., Cervantes, S., Samaranch, L., Pastor, P., Martí, M. J., Muñoz, E., Valldeoriola, F., Aguilar, M., Calopa, M., Hernández-Vara, J., Tolosa, E.

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Analysis of the GIGYF2 gene in familial and sporadic Parkinson disease in the Spanish population by Samaranch, L., Lorenzo, E., Pastor, M. A., Riverol, M., Luquin, M. R., Rodríguez-Oroz, M. C., Obeso, J. A., Pastor, P.

“…Background and purpose:  Linkage analysis in familial Parkinson’s disease (PD) identified a locus in 2q36‐37 (PARK11). Sequencing of GIGYF2 identified several…”
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Genes related to iron metabolism and susceptibility to Alzheimer's disease in Basque population by Blázquez, L, De Juan, D, Ruiz-Martínez, J, Emparanza, J.I, Sáenz, A, Otaegui, D, Sistiaga, A, Martínez-Lage, P, Lamet, I, Samaranch, L, Buiza, C, Etxeberria, I, Arriola, E, Cuadrado, E, Urdaneta, E, Yanguas, J, López de Munain, A

“…Abstract Alzheimer's disease (AD) is the most common dementing disorder and presents with a progressive and irreversible cognitive decline of gradual onset. To…”
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Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates by Samaranch, Lluis, Salegio, Ernesto A, San Sebastian, Waldy, Kells, Adrian P, Foust, Kevin D, Bringas, John R, Lamarre, Clementine, Forsayeth, John, Kaspar, Brian K, Bankiewicz, Krystof S

“…Widespread distribution of gene products at clinically relevant levels throughout the CNS has been challenging. Adeno-associated virus type 9 (AAV9) vector has…”
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Guided delivery of adeno-associated viral vectors into the primate brain by Salegio, Ernesto A., Samaranch, Lluis, Kells, Adrian P., Forsayeth, John, Bankiewicz, Krystof

“…In this review, we discuss recent developments in the delivery of adeno-associated virus-based vectors (AAV), particularly with respect to the role of axonal…”
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Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice by Ribé, Elena M., Pérez, Mar, Puig, Berta, Gich, Ignasi, Lim, Filip, Cuadrado, Mar, Sesma, Teresa, Catena, Silvia, Sánchez, Belén, Nieto, María, Gómez-Ramos, Pilar, Morán, M.Asunción, Cabodevilla, Felipe, Samaranch, Lluis, Ortiz, Lourdes, Pérez, Alberto, Ferrer, Isidro, Avila, Jesús, Gómez-Isla, Teresa

“…Even though the idea that amyloid β peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the…”
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Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain by Salegio, Ernesto A, Samaranch, Lluis, Jenkins, Russell W, Clarke, Christopher J, Lamarre, Clementine, Beyer, Janine, Kells, Adrian P, Bringas, John, Sebastian, Waldy San, Richardson, R Mark, Rosenbluth, Kate H, Hannun, Yusuf A, Bankiewicz, Krystof S, Forsayeth, John

“…Niemann-Pick disease is a lysosomal storage disorder resulting from inherited deficiency in acid sphingomyelinase (ASM). Use of adeno-associated virus serotype…”
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Mutational Screening of PARKIN Identified a 3′ UTR Variant (rs62637702) Associated with Parkinson’s Disease by de Mena, Lorena, Samaranch, LLuís, Coto, Eliecer, Cardo, Lucía F., Ribacoba, René, Lorenzo-Betancor, Oswaldo, Pastor, Pau, Wang, Li, Irigoyen, Jaione, Mata, Ignacio F., Díaz, Marta, Moris, Germán, Menéndez, Manuel, Corao, Ana I., Lorenzo, Elena, Alvarez, Victoria

“…PRKN mutations have been linked to Parkinson’s disease (PD). Most of the mutational screenings have focused on the coding exons. The 3′ untranslated region…”
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Lack of interaction of SNCA and MAPT genotypes in Parkinson's disease: LETTER TO THE EDITOR by Botta-Orfila, T., Ezquerra, M., Ríos, J., Fernández-Santiago, R., Cervantes, S., Samaranch, L., Pastor, P., Martí, M. J., Muñoz, E., Valldeoriola, F., Aguilar, M., Calopa, M., Hernández-Vara, J., Tolosa, E.

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