Search Results - "Samantha A. Morris"

The evolving concept of cell identity in the single cell era by Morris, Samantha A

“…Fueled by recent advances in single cell biology, we are moving away from qualitative and undersampled assessments of cell identity, toward building…”
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Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development by VanHorn, Sadie, Morris, Samantha A.

“…Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and their progeny, have evolved rapidly over the last century. Lineage…”
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Direct lineage reprogramming via pioneer factors; a detour through developmental gene regulatory networks by Morris, Samantha A

“…Although many approaches have been employed to generate defined fate in vitro, the resultant cells often appear developmentally immature or incompletely…”
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Single-cell mapping of lineage and identity in direct reprogramming by Biddy, Brent A., Kong, Wenjun, Kamimoto, Kenji, Guo, Chuner, Waye, Sarah E., Sun, Tao, Morris, Samantha A.

“…Direct lineage reprogramming involves the conversion of cellular identity. Single-cell technologies are useful for deconstructing the considerable…”
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CellNet: Network Biology Applied to Stem Cell Engineering by Cahan, Patrick, Li, Hu, Morris, Samantha A., Lummertz da Rocha, Edroaldo, Daley, George Q., Collins, James J.

“…Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct conversions between differentiated cell lineages represent…”
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A blueprint for engineering cell fate： current technologies to reprogram cell identity by Morris, Samantha A, Daley, George Q

“…Human diseases such as heart failure, diabetes, neurodegenerative disorders, and many others result from the deficiency or dysfunction of critical cell types…”
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Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet by Morris, Samantha A., Cahan, Patrick, Li, Hu, Zhao, Anna M., San Roman, Adrianna K., Shivdasani, Ramesh A., Collins, James J., Daley, George Q.

“…Engineering clinically relevant cells in vitro holds promise for regenerative medicine, but most protocols fail to faithfully recapitulate target cell…”
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CellTag Indexing: genetic barcode-based sample multiplexing for single-cell genomics by Guo, Chuner, Kong, Wenjun, Kamimoto, Kenji, Rivera-Gonzalez, Guillermo C, Yang, Xue, Kirita, Yuhei, Morris, Samantha A

“…High-throughput single-cell assays increasingly require special consideration in experimental design, sample multiplexing, batch effect removal, and data…”
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Capybara: A computational tool to measure cell identity and fate transitions by Kong, Wenjun, Fu, Yuheng C., Holloway, Emily M., Garipler, Görkem, Yang, Xue, Mazzoni, Esteban O., Morris, Samantha A.

“…Measuring cell identity in development, disease, and reprogramming is challenging as cell types and states are in continual transition. Here, we present…”
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Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo by Zernicka-Goetz, Magdalena, Morris, Samantha A, Bruce, Alexander W

“…Key Points This Review aims to collate our current understanding of the molecular processes that govern the two necessary cell fate decisions made by the…”
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High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures by Minn, Kyaw Thu, Fu, Yuheng C, He, Shenghua, Dietmann, Sabine, George, Steven C, Anastasio, Mark A, Morris, Samantha A, Solnica-Krezel, Lilianna

“…During mammalian gastrulation, germ layers arise and are shaped into the body plan while extraembryonic layers sustain the embryo. Human embryonic stem cells,…”
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Developmental Plasticity Is Bound by Pluripotency and the Fgf and Wnt Signaling Pathways by Morris, Samantha A., Guo, Yu, Zernicka-Goetz, Magdalena

“…Plasticity is a well-known feature of mammalian development, and yet very little is known about its underlying mechanism. Here, we establish a model system to…”
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Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs by Cates, Kitra, McCoy, Matthew J., Kwon, Ji-Sun, Liu, Yangjian, Abernathy, Daniel G., Zhang, Bo, Liu, Shaopeng, Gontarz, Paul, Kim, Woo Kyung, Chen, Shawei, Kong, Wenjun, Ho, Joshua N., Burbach, Kyle F., Gabel, Harrison W., Morris, Samantha A., Yoo, Andrew S.

“…Cell-fate conversion generally requires reprogramming effectors to both introduce fate programs of the target cell type and erase the identity of starting cell…”
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Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo by Morris, Samantha A, Teo, Roy T.Y, Li, Huiliang, Robson, Paul, Glover, David M, Zernicka-Goetz, Magdalena

“…A crucial question in mammalian development is how cells of the early embryo differentiate into distinct cell types. The first decision is taken when cells…”
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The coding and long noncoding single-cell atlas of the developing human fetal striatum by Bocchi, Vittoria Dickinson, Conforti, Paola, Vezzoli, Elena, Besusso, Dario, Cappadona, Claudio, Lischetti, Tiziana, Galimberti, Maura, Ranzani, Valeria, Bonnal, Raoul J P, De Simone, Marco, Rossetti, Grazisa, He, Xiaoling, Kamimoto, Kenji, Espuny-Camacho, Ira, Faedo, Andrea, Gervasoni, Federica, Vuono, Romina, Morris, Samantha A, Chen, Jian, Felsenfeld, Dan, Pavesi, Giulio, Barker, Roger A, Pagani, Massimiliano, Cattaneo, Elena

“…Deciphering how the human striatum develops is necessary for understanding the diseases that affect this region. To decode the transcriptional modules that…”
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Anniversary reflections: Inspiring discoveries and the future of the field by Lancaster, Madeline, Morris, Samantha A, Takebe, Takanori, Qian, Li, Gao, Shaorong, Huch, Meritxell

“…Cell Stem Cell was launched in 2007, and this year marks its 15 anniversary. To recognize this occasion, we asked six advisory board members to reflect on…”
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Gene regulatory network reconfiguration in direct lineage reprogramming by Kamimoto, Kenji, Adil, Mohd Tayyab, Jindal, Kunal, Hoffmann, Christy M., Kong, Wenjun, Yang, Xue, Morris, Samantha A.

“…In direct lineage conversion, transcription factor (TF) overexpression reconfigures gene regulatory networks (GRNs) to reprogram cell identity. We previously…”
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Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis by Diaz, Miguel F, Li, Nan, Lee, Hyun Jung, Adamo, Luigi, Evans, Siobahn M, Willey, Hannah E, Arora, Natasha, Torisawa, Yu-Suke, Vickers, Dwayne A, Morris, Samantha A, Naveiras, Olaia, Murthy, Shashi K, Ingber, Donald E, Daley, George Q, García-Cardeña, Guillermo, Wenzel, Pamela L

“…Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that…”
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Human embryos cultured in vitro to 14 days by Morris, Samantha A.

“…We know a great deal about the development of the mammalian embryo until the time that the blastocyst implants into the uterus. With model organisms such as…”
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Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst by Meilhac, Sigolène M., Adams, Richard J., Morris, Samantha A., Danckaert, Anne, Le Garrec, Jean-François, Zernicka-Goetz, Magdalena

“…In the mouse blastocyst, some cells of the inner cell mass (ICM) develop into primitive endoderm (PE) at the surface, while deeper cells form the epiblast. It…”
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