Search Results - "Samanta, Jayshree"

Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation by Samanta, Jayshree, Kessler, John A

“…Bone morphogenetic protein (BMP) signaling inhibits the generation of oligodendroglia and enhances generation of astrocytes by neural progenitor cells both in…”
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Myelination: Actin Disassembly Leads the Way by Samanta, Jayshree, Salzer, James L.

“…The mechanisms that drive the spiral wrapping of the myelin sheath around axons are poorly understood. Two papers in this issue of Developmental Cell…”
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Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain by Radecki, Daniel Z, Samanta, Jayshree

“…Oligodendrogenesis is essential for replacing worn-out oligodendrocytes, promoting myelin plasticity, and for myelin repair following a demyelinating injury in…”
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Transcriptomic analysis of loss of Gli1 in neural stem cells responding to demyelination in the mouse brain by Samanta, Jayshree, Silva, Hernandez Moura, Lafaille, Juan J., Salzer, James L.

“…In the adult mammalian brain, Gli1 expressing neural stem cells reside in the subventricular zone and their progeny are recruited to sites of demyelination in…”
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Isolation and culture of neural stem cells from adult mouse subventricular zone for genetic and pharmacological treatments with proliferation analysis by Radecki, Daniel Z., Samanta, Jayshree

“…Neural stem cells (NSCs) from the subventricular zone (SVZ) of the mouse brain can be expanded in vitro and grown as neurospheres, which can be stored…”
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LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells by Bonaguidi, Michael A, McGuire, Tammy, Hu, Min, Kan, Lixin, Samanta, Jayshree, Kessler, John A

“…Bone morphogenetic protein (BMP) and leukemia inhibitory factor (LIF) signaling both promote the differentiation of neural stem/progenitor cells into glial…”
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Immunofluorescence assay for demyelination, remyelination, and proliferation in an acute cuprizone mouse model by Clawson, Elizabeth D., Radecki, Daniel Z., Samanta, Jayshree

“…Here, we present a protocol to assess demyelination in the corpus callosum of an acute cuprizone mouse model, which is routinely used to induce demyelination…”
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Noggin Protects Against Ischemic Brain Injury in Rodents by SAMANTA, Jayshree, ALDEN, Tord, GOBESKE, Kevin, KAN, Lixin, KESSLER, John A

“…Bone morphogenetic proteins and their receptors are expressed in adult brains, and their expression levels increase after cerebral ischemia. The brain also…”
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BMPR1a Signaling Determines Numbers of Oligodendrocytes and Calbindin-Expressing Interneurons in the Cortex by Samanta, Jayshree, Burke, Gordon M, McGuire, Tammy, Pisarek, Anna J, Mukhopadhyay, Abhishek, Mishina, Yuji, Kessler, John A

“…Progenitor cells that express the transcription factor olig1 generate several neural cell types including oligodendrocytes and GABAergic interneurons in the…”
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Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo by Guha, Udayan, Gomes, William A, Samanta, Jayshree, Gupta, Meenakshi, Rice, Frank L, Kessler, John A

“…The role of target-derived BMP signaling in development of sensory ganglia and the sensory innervation of the skin was examined in transgenic animals that…”
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Activated microglia drive demyelination via CSF1R signaling by Marzan, Dave E., Brügger‐Verdon, Valérie, West, Brian L., Liddelow, Shane, Samanta, Jayshree, Salzer, James L.

“…Microgliosis is a prominent pathological feature in many neurological diseases including multiple sclerosis (MS), a progressive auto‐immune demyelinating…”
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Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination by Samanta, Jayshree, Grund, Ethan M., Silva, Hernandez M., Lafaille, Juan J., Fishell, Gord, Salzer, James L.

“…A subset of adult neural stem cells, responsive to sonic hedgehog, are more effective at remyelination when the transcription factor Gli1 is inhibited…”
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Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture by Zotter, Brendan, Dagan, Or, Brady, Jacob, Baloui, Hasna, Samanta, Jayshree, Salzer, James L

“…Peripheral nerves are organized into discrete compartments. Axons, Schwann cells (SCs), and endoneurial fibroblasts (EFs) reside within the endoneurium and are…”
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Wobbly hedgehog syndrome- a progressive neurodegenerative disease by Doss, Grayson A., Radecki, Daniel Z., Kethireddy, Arya, Reilly, Madelyn J., Pohly, Andrea E., August, Benjamin K., Duncan, Ian D., Samanta, Jayshree

“…Wobbly hedgehog syndrome (WHS) has been long considered to be a myelin disease primarily affecting the four-toed hedgehog. In this study, we have shown for the…”
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Relative Levels of Gli1 and Gli2 Determine the Response of Ventral Neural Stem Cells to Demyelination by Radecki, Daniel Z., Messling, Heather M., Haggerty-Skeans, James R., Bhamidipati, Sai Krishna, Clawson, Elizabeth D., Overman, Christian A., Thatcher, Madison M., Salzer, James L., Samanta, Jayshree

“…Enhancing repair of myelin is an important therapeutic goal in many neurological disorders characterized by demyelination. In the healthy adult brain, ventral…”
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Regulation of neural lineage commitment by bone morphogenetic protein four by Samanta, Jayshree

“…Bone morphogenetic protein (BMP) signaling inhibits the generation of oligodendroglia by neural progenitor cells both in vitro and in vivo. This study examined…”
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