Search Results - "Samanta, Ajoy K"

Janus kinase 2: a critical target in chronic myelogenous leukemia by Samanta, Ajoy K, Lin, Hui, Sun, Tong, Kantarjian, Hagop, Arlinghaus, Ralph B

“…The Bcr-Abl tyrosine kinase is the causative factor in most chronic myelogenous leukemia (CML) patients. We have shown that Bcr-Abl is associated with a…”
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MEKK3 expression correlates with nuclear factor κ B activity and with expression of antiapoptotic genes in serous ovarian carcinoma by Samanta, Ajoy K., Huang, Helen J., Le, Xiao‐Feng, Mao, Weiqun, Lu, Karen H., Bast, Robert C., Liao, Warren S.‐L.

“…BACKGROUND: Constitutively activated nuclear factor κ B (NFκB) contributes to the development of cancer by regulating the expression of genes involved in cell…”
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Destabilization of Bcr-Abl/Jak2 Network by a Jak2/Abl Kinase Inhibitor ON044580 Overcomes Drug Resistance in Blast Crisis Chronic Myelogenous Leukemia (CML) by Samanta, Ajoy K, Chakraborty, Sandip N, Wang, Yan, Schlette, Ellen, Reddy, E Premkumar, Arlinghaus, Ralph B

“…Bcr-Abl is the predominant therapeutic target in chronic myeloid leukemia (CML), and tyrosine kinase inhibitors (TKIs) that inhibit Bcr-Abl have been…”
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A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition by Jatiani, Shashidhar S, Cosenza, Stephen C, Reddy, M V Ramana, Ha, Ji Hee, Baker, Stacey J, Samanta, Ajoy K, Olnes, Matthew J, Pfannes, Loretta, Sloand, Elaine M, Arlinghaus, Ralph B, Reddy, E Premkumar

“…Here we report the discovery of ON044580, an α-benzoyl styryl benzyl sulfide that possesses potent inhibitory activity against two unrelated kinases, JAK2 and…”
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The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation by Reddy, Shrikanth A.G, Lin, Yu-Feng, Huang, Helen J, Samanta, Ajoy K, Liao, Warren S.-L

“…Interleukin-1 (IL-1) binds to its type I receptors (IL-1R), which in complex with IL-1R accessory protein (IL-1R AcP) induces various intracellular signaling…”
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Enhanced Jak2 Activation Correlates with β Chain Expression Leading to Phosphorylation of Tyrosine 177 of Bcr-Abl by Tao, Wenjing, Samanta, Ajoy K., Priebe, Waldemar, Arlinghaus, Ralph B.

“…Abstract 2170 Poster Board II-147 We have previously published that NIH 3T3 cells, which are known to be resistant to Bcr-Abl transformation, are greatly…”
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Binding of Escherichia coli heat-stable enterotoxin and rise of cyclic GMP in COLO 205 human colonic carcinoma cells by Bhattacharya, Jayanta, Ghosh Chaudhuri, Alok, Sinha, Ajoy K., Samanta, Ajoy K., Chakrabarti, Manoj K.

“…Abstract Escherichia coli heat-stable enterotoxin (STa) was found to bind on the surface of human colonic (COLO 205) cells. The binding of [125I]STa to cell…”
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Jak2 Regulates Bcr-Abl In CD34+ Cells From Imatinib Mesylate-Resistant CML Patients by Samanta, Ajoy K., Perazzona, Bastianella, Chakraborty, Sandip N., Sun, Xiaoping, Modi, Hardik, Bhatia, Ravi, Arlinghaus, Ralph B.

“…Abstract 1220 Despite the success of imatinib mesylate (IM), complete molecular remission is difficult to achieve in IM-treated CML patients. After continuing…”
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Jak2 Phosphorylates Tyr 177 of Bcr-Abl Activating the Ras and PI-3 Kinase Pathways and Maintains Functional Levels of Bcr-Abl in Chronic Myelogenous Leukemia by Samanta, Ajoy K., Chakraborty, Sandip N., Sun, Xiaoping, Schlette, Ellen, Priebe, Waldemar, Arlinghaus, Ralph B.

“…Abstract 39 We have shown that Jak2 is activated in Bcr-Abl+ hematopoietic cells. Our findings indicate that Jak2 kinase inhibition overcomes drug-resistance…”
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Overexpression of MEKK3 Confers Resistance to Apoptosis through Activation of NFκB by Samanta, Ajoy K., Huang, Helen J., Bast, Robert C., Liao, Warren S.-L.

“…Many cancers have constitutively activated NFκB, the elevation of which contributes to cancer cell resistance to chemotherapeutic agent-induced apoptosis…”
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Disruption of the Bcr-Abl/Jak2/HSP90 Network Complex Leading to Induction of Apoptosis in Drug-Resistant CML Cells by a New Compound WP1193 by Samanta, Ajoy K., Chakraborty, Sandip N., Samanta, Susmita, Wang, Yan, Sun, Xiaoping, Schlette, E., Priebe, Waldemar, Arlinghaus, Ralph B.

“…In chronic myelogenous leukemia (CML), treatment of early stage disease has been significantly improved with the discovery of imatinib mesylate (IM, Gleevec),…”
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Oncogenic Transformation of NIH 3T3 Fibroblasts by BCR-ABL Oncoprotein Requires the IL-3 Receptor by Tao, Wenjing, Lin, Hui, Sun, Tong, Samanta, Ajoy K., Arlinghaus, Ralph B.

“…Bcr-Abl is a leukemia-inducing protein, which causes oncogenic transformation of myeloid progenitors in Philadelphia chromosome (Ph)-positive chronic myeloid…”
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Jak2 Regulates Lyn Tyrosine Kinase through Interference with the SET/PP2A/Shp1 Pathway and Inhibition of Jak2 Induced Apoptosis in BCR-ABL+ Imatinib-Sensitive and Resistant CML Cells by Samanta, Ajoy K., Chakravorty, Sandip, Wang, Yan, Cortes, Jorge, Kantarjian, Hagop, Champlin, Richard E., Perrotti, Danilo, Arlinghaus, Ralph B.

“…Chronic myelogenous leukemia (CML) patients treated with imatinib mesylate (IM) results in drug resistance in accelerated and blast crisis stages predominantly…”
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Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1α by interferon-β by Zang, Ying C.Q., Halder, Jyotsnabaran B., Samanta, Ajoy K., Hong, Jian, Rivera, Victor M., Zhang, Jingwu Z.

“…Trafficking of inflammatory T cells into the brain is associated with interactions of certain chemokines with their receptors, which plays an important role in…”
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Jak2: A Potential Therapeutic Target for Chronic Myelogenous Leukemia (CML) by Samanta, Ajoy K., Lin, Hui, Sun, Tong, Kantarjian, Hagop, Arlinghaus, Ralph B.

“…In most CML patients Bcr-Abl, a constitutively active tyrosine kinase derived from the Philadelphia chromosome, is highly expressed and is the causative factor…”
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Aberrant T cell migration toward RANTES and MIP-1α in patients with multiple sclerosis. Overexpression of chemokine receptor CCR5 by ZANG, Y. C. Q, SAMANTA, A. K, HALDER, J. B, JIAN HONG, TEJADA-SIMON, M. V, RIVERA, V. M, ZHANG, J. Z

“…Trafficking of inflammatory T cells into the central nervous system (CNS) plays an important role in the pathogenesis of multiple sclerosis. The directional…”
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Modulation of interleukin-8 receptor expression by lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) in human peripheral monocytes--a preliminary study by Bishayi, Biswadev, Samanta, Ajoy K

“…Interleukin-8, a monocyte derived neutrophil chemotactic agent is known to play as a key mediator in the pathogenesis of a large number of neutrophil driven…”
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Overexpression of MEKK3 Confers Resistance to Apoptosis through Activation of NFκB by Ajoy K. Samanta, Helen J. Huang, Robert C. Bast, Jr, Warren S.-L. Liao

“…Many cancers have constitutively activated NFκB, the elevation of which contributes to cancer cell resistance to chemotherapeutic agent-induced apoptosis…”
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Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB by Samanta, Ajoy K, Huang, Helen J, Bast, Jr, Robert C, Liao, Warren S-L

“…Many cancers have constitutively activated NFkappaB, the elevation of which contributes to cancer cell resistance to chemotherapeutic agent-induced apoptosis…”
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MEKK3 EXPRESSION CORRELATES WITH NFκB ACTIVITY AND WITH EXPRESSION OF ANTI-APOPTOTIC GENES IN SEROUS OVARIAN CARCINOMA by Samanta, Ajoy K., Huang, Helen J., Le, Xiao-Feng, Mao, Weiqun, Lu, Karen H., Bast, Robert C., Liao, Warren S.-L.

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