Search Results - "Samant, Manoj"

Novel exenatide analogs with peptidic albumin binding domains: potent anti-diabetic agents with extended duration of action by Levy, Odile E, Jodka, Carolyn M, Ren, Shijun Steven, Mamedova, Lala, Sharma, Abhinandini, Samant, Manoj, D'Souza, Lawrence J, Soares, Christopher J, Yuskin, Diane R, Jin, Li Jenny, Parkes, David G, Tatarkiewicz, Krystyna, Ghosh, Soumitra S

“…The design, synthesis and pharmacology of novel long-acting exenatide analogs for the treatment of metabolic diseases are described. These molecules display…”
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Novel Analogues of Degarelix Incorporating Hydroxy-, Methoxy-, and Pegylated-Urea Moieties at Positions 3, 5, 6 and the N-Terminus. Part III by Samant, Manoj P, Hong, Doley J, Croston, Glenn, Rivier, Catherine, Rivier, Jean

“…Novel degarelix (Fe200486) analogues were screened for antagonism of GnRH-induced response (IC50) in a reporter gene assay. Inhibition of luteinizing hormone…”
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Norcystine, a New Tool for the Study of the Structure−Activity Relationship of Peptides by Samant, Manoj P, Rivier, Jean E

“…Norcysteine (Ncy) is an unnatural amino acid possessing an electronegative sulfur atom directly attached to the α-carbon atom. We describe the synthesis of…”
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Structure−Activity Relationship Studies of Gonadotropin-Releasing Hormone Antagonists Containing S-Aryl/Alkyl Norcysteines and Their Oxidized Derivatives by Samant, Manoj P, White, Richard, Hong, Doley J, Croston, Glenn, Conn, P. Michael, Janovick, Jo Ann, Rivier, Jean

“…A series of acyline analogues incorporating l- and d-isomers of S-arylated/alkylated norcysteines [Ncy(R), where R is 2-naphthyl, methyl, and isopropyl] at…”
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Synthesis of protected norcysteines for SPPS compatible with Fmoc strategy by Samant, Manoj P., Rivier, Jean E.

“…We report the synthesis of racemic Alloc-Ncy(Tmob)–OH, the resolution of its methyl ester and demonstrate its application to form a norcystine bridge in…”
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Iterative Approach to the Discovery of Novel Degarelix Analogues:  Substitutions at Positions 3, 7, and 8. Part II by Samant, Manoj P, Gulyas, Jozsef, Hong, Doley J, Croston, Glenn, Rivier, Catherine, Rivier, Jean

“…Degarelix (FE200486, Ac-d-2Nal-d-4Cpa-d-3Pal-Ser-4Aph(l-Hor)-d-4Aph(Cbm)-Leu-ILys-Pro-d-Ala-NH2) is a potent and very long acting antagonist of…”
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Novel gonadotropin-releasing hormone antagonists with substitutions at position 5 by Samant, Manoj P., Hong, Doley J., Croston, Glenn, Rivier, Catherine, Rivier, Jean

“…Gonadotropin‐releasing hormone (GnRH) antagonists with high potency and improved duration of action are needed for potential clinical applications. We…”
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Synthesis, in vivo and in vitro biological activity of novel azaline B analogs by Samant, Manoj P., Gulyas, Jozsef, Hong, Doley J., Croston, Glenn, Rivier, Catherine, Rivier, Jean

“…[Display omitted] Several azaline B analogs ( 2– 10) were synthesized and evaluated for their ability to antagonize GnRH in vitro and for duration of action in…”
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Self-Assembling, Cystine-Derived, Fused Nanotubes Based on Spirane Architecture:  Design, Synthesis, and Crystal Structure of Cystinospiranes by Ranganathan, Darshan, Samant, Manoj P, Karle, Isabella L

“…A novel family of cystine-based spirobicyclic peptides (cystinospiranes) has been synthesized by a single-step procedure involving condensation of…”
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Efficacy and safety of mavrilimumab in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial by Cid, Maria C, Unizony, Sebastian H, Blockmans, Daniel, Brouwer, Elisabeth, Dagna, Lorenzo, Dasgupta, Bhaskar, Hellmich, Bernhard, Molloy, Eamonn, Salvarani, Carlo, Trapnell, Bruce C, Warrington, Kenneth J, Wicks, Ian, Samant, Manoj, Zhou, Teresa, Pupim, Lara, Paolini, John F

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is implicated in pathogenesis of giant cell arteritis. We evaluated the efficacy of the GM-CSF…”
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Design, synthesis and membrane ion transport properties of cystine- and serine-based cyclo -4-oxa-heptane-1,7-bisamides by Ranganathan, Darshan, Samant, Manoj P, Nagaraj, R, Bikshapathy, E

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Abstract 12057: Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and mRNA Vaccinations: Experience From Phase 3 Rhapsody Long-Term Extension by brucato, antonio, Trotta, Lucia, Arad, Michael, Cremer, Paul C, Gaddam, Eliyazar, Insalaco, Antonella, Klutstein, Marc W, Lewinter, Martin M, Lin, David, Luis, Sushil A, Wasserstrum, Yishay, Plummer, Emily, Samant, Manoj, Zou, Liangxing, Klein, Allan L, Imazio, Massimo, Paolini, John F

“…IntroductionRare cardiac complications of COVID-19 and COVID-19 mRNA vaccination include pericarditis and myocarditis. Patients with recurrent pericarditis may…”
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Abstract 11653: Prolonged Rilonacept Treatment in Rhapsody Long-Term Extension Provided Persistent Reduction of Pericarditis Recurrence Risk by Imazio, Massimo, Klein, Allan L, Abbate, Antonio, Arad, Michael, brucato, antonio, Cremer, Paul C, Gaddam, Eliyazar, Insalaco, Antonella, Lewinter, Martin M, Lewis, Basil, Lin, David, Luis, Sushil A, Nicholls, Stephen J, Sutej, Paul, Wasserstrum, Yishay, Samant, Manoj, Zou, Liangxing, Fang, Fang, Paolini, John F

“…IntroductionRilonacept reduced pericarditis recurrence in the phase 3 trial RHAPSODY. The long-term extension (LTE) enabled further insights into efficacy,…”
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NOAA National Water Level Observation Network Recapitalization by Loesch, Robert, Edwing, Richard, Teng, Chung-Chu, Ache, Brent, Licate, Louis, Samant, Manoj, Mowery, Scott

“…This paper describes the recently developed plan to systematically recapitalize the entire National Oceanic and Atmospheric Administration (NOAA) National…”
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Pseudoprogression (PsP) in Patients with Peripheral T-Cell Lymphoma (PTCL) Treated with the Novel Stapled Peptide ALRN-6924, a Dual Inhibitor of MDMX and MDM2 by Shustov, Andrei R., Mehta, Amitkumar, Sokol, Lubomir, Carvajal, Luis A., Guerlavais, Vincent, Samant, Manoj, Narasimhan, Narayana, Sutton, David, Annis, D. Allen, Pinchasik, Dawn, Aivado, Manuel, Korn, Ronald

“…Background: ALRN-6924, an α-helical stapled p53 peptide, is the first-in-class and only dual inhibitor of MDMX and MDM2 currently in clinical trials for both,…”
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Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins) by Erchegyi, Judit, Wang, Lixin, Gulyas, Jozsef, Samant, Manoj, Perrin, Marilyn H, Lewis, Kathy, Miller, Charleen, Vaughan, Joan, Donaldson, Cynthia, Fischer, Wolfgang, Low, William, Yakabi, Seiichi, Karasawa, Hiroshi, Taché, Yvette, Rivier, Catherine, Rivier, Jean

“…CRF mediates numerous stress-related endocrine, autonomic, metabolic, and behavioral responses. We present the synthesis and chemical and biological properties…”
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Abstract CT109: First-in-class first-in-human phase 1 trial and translational study of the mono(ADP-ribose) polymerase-7 (PARP7) inhibitor RBN-2397 in patients with selected advanced solid tumors by Yap, Timothy A., Cervantes, Andres, Falchook, Gerald S., Patel, Manish R., Juric, Dejan, Waqar, Saiama N., Schenk, Erin L., Shapiro, Geoffrey, Boni, Valentina, Perez, Cesar A., Burtness, Barbara, Najjar, Yana G., Racca, Fabricio, Rojas, Katerin, Kuplast-Barr, Kristy, McEachern, Kristen, Samant, Manoj, Bozón, Viviana, Parasuraman, Sudha, Johnson, Melissa

“…Abstract Background: PARP7 is a stress-induced monoART that suppresses the cellular type I interferon (IFN) response following cytosolic nucleic acid sensing…”
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Ring Size of Somatostatin Analogues (ODT-8) Modulates Receptor Selectivity and Binding Affinity by Erchegyi, Judit, Grace, Christy Rani R, Samant, Manoj, Cescato, Renzo, Piccand, Veronique, Riek, Roland, Reubi, Jean Claude, Rivier, Jean E

“…The synthesis, biological testing, and NMR studies of several analogues of H-c[Cys3-Phe6-Phe7-DTrp8-Lys9-Thr10-Phe11-Cys14]-OH (ODT-8, a pan-somatostatin…”
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Ring Size in Octreotide Amide Modulates Differently Agonist versus Antagonist Binding Affinity and Selectivity by Grace, Christy Rani R, Erchegyi, Judit, Samant, Manoj, Cescato, Renzo, Piccand, Veronique, Riek, Roland, Reubi, Jean Claude, Rivier, Jean E

“…H-DPhe2-c[Cys3-Phe7-DTrp8-Lys9-Thr10-Cys14]-Thr15-NH2 (1) (a somatostatin agonist, SRIF numbering) and H-Cpa2-c[DCys3-Tyr7-DTrp8-Lys9-Thr10-Cys14]-Nal15-NH2…”
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Novel Exenatide Analogs with Peptidic Albumin Binding Domains: Potent Anti-Diabetic Agents with Extended Duration of Action: e87704 by Levy, Odile E, Jodka, Carolyn M, Ren, Shijun Steven, Mamedova, Lala, Sharma, Abhinandini, Samant, Manoj, D'Souza, Lawrence J, Soares, Christopher J, Yuskin, Diane R, Jin, Li Jenny

“…The design, synthesis and pharmacology of novel long-acting exenatide analogs for the treatment of metabolic diseases are described. These molecules display…”
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