Search Results - "Samankumara, Lalith P"

The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging by Abuteen, Akram, Zanganeh, Saeid, Akhigbe, Joshua, Samankumara, Lalith P, Aguirre, Andres, Biswal, Nrusingh, Braune, Marcel, Vollertsen, Anke, Röder, Beate, Brückner, Christian, Zhu, Quing

“…Six free base tetrapyrrolic chromophores, three quinoline-annulated porphyrins and three morpholinobacteriochlorins, that absorb light in the near-IR range and…”
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Efficient Asymmetric Synthesis of Structurally Diverse P-Stereogenic Phosphinamides for Catalyst Design by Han, Zhengxu S., Zhang, Li, Xu, Yibo, Sieber, Joshua D., Marsini, Maurice A., Li, Zhibin, Reeves, Jonathan T., Fandrick, Keith R., Patel, Nitinchandra D., Desrosiers, Jean-Nicolas, Qu, Bo, Chen, Anji, Rudzinski, DiAndra M., Samankumara, Lalith P., Ma, Shengli, Grinberg, Nelu, Roschangar, Frank, Yee, Nathan K., Wang, Guijun, Song, Jinhua J., Senanayake, Chris H.

“…The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a…”
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Syntheses of Bis‐Triazole Linked Carbohydrate Based Macrocycles and Their Applications for Accelerating Copper Sulfate Mediated Click Reaction by Chen, Anji, Samankumara, Lalith P., Dodlapati, Sanjeeva, Wang, Dan, Adhikari, Surya, Wang, Guijun

“…Macrocyclic compounds play an important role in many research fields including drug discovery and development, bioorganic chemistry, and materials sciences…”
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Stable isotope synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites by Latli, Bachir, Hrapchak, Matt J, Chevliakov, Maxim, Samankumara, Lalith P, Frutos, Rogelio P, Lee, Heewon

“…Stable isotope labeled Iclepertin (BI 425809, 1) and its major metabolites are needed as internal standards in bioanalytical studies. BI 425809 consists of two…”
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Synthesis of Chiral 1,2-Amino Alcohol-Containing Compounds Utilizing Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Unprotected α‑Ketoamines by Mangunuru, Hari P. R., Terrab, Leila, Janganati, Venumadhav, Kalikinidi, Nageswara Rao, Tenneti, Srinivasarao, Natarajan, Vasudevan, Shada, Arun D. R., Naini, Santhosh Reddy, Gajula, Praveen, Lee, Daniel, Samankumara, Lalith P., Mamunooru, Manasa, Jayaraman, Aravindan, Sahani, Rajkumar Lalji, Yin, Jinya, Hewa-Rahinduwage, Chathuranga C., Gangu, Aravind, Chen, Anji, Wang, Zhirui, Desai, Bimbisar, Yue, Tai Y., Wannere, Chaitanya S., Armstrong, Joseph D., Donsbach, Kai O., Sirasani, Gopal, Gupton, B. Frank, Qu, Bo, Senanayake, Chris H.

“…Herein, we disclose a facile synthetic strategy to access an important class of drug molecules that contain chiral 1,2-amino alcohol functionality utilizing…”
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Synthesis of Enantioenriched 2‑Alkyl Piperidine Derivatives through Asymmetric Reduction of Pyridinium Salts by Qu, Bo, Mangunuru, Hari P. R, Wei, Xudong, Fandrick, Keith R, Desrosiers, Jean-Nicolas, Sieber, Joshua D, Kurouski, Dmitry, Haddad, Nizar, Samankumara, Lalith P, Lee, Heewon, Savoie, Jolaine, Ma, Shengli, Grinberg, Nelu, Sarvestani, Max, Yee, Nathan K, Song, Jinhua J, Senanayake, Chris H

“…An Ir-catalyzed enantioselective hydrogenation of 2-alkyl-pyridines has been developed using ligand MeO-BoQPhos. High levels of enantioselectivities up to 93:7…”
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Bacteriochlorins with a Twist: Discovery of a Unique Mechanism to Red-Shift the Optical Spectra of Bacteriochlorins by Guberman-Pfeffer, Matthew J, Greco, Jordan A, Samankumara, Lalith P, Zeller, Matthias, Birge, Robert R, Gascón, José A, Brückner, Christian

“…Owing to their intense near infrared absorption and emission properties, to the ability to photogenerate singlet oxygen, or to act as photoacoustic imaging…”
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Indachlorins: Nonplanar Indanone-Annulated Chlorin Analogues with Panchromatic Absorption Spectra between 300 and 900 nm by Samankumara, Lalith P., Dorazio, Sarina J., Akhigbe, Joshua, Li, Ruoshi, Nimthong-Roldán, Arunpatcha, Zeller, Matthias, Brückner, Christian

“…Indaphyrins, pyrrole‐modified porphyrins containing a cleaved pyrrole β,β′‐bond and two annulated indanone moieties, possess unusually broadened and redshifted…”
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Indachlorins: Nonplanar Indanone-Annulated Chlorin Analogues with Panchromatic Absorption Spectra between 300 and 900nm by Samankumara, Lalith P, Dorazio, Sarina J, Akhigbe, Joshua, Li, Ruoshi, Nimthong-Roldan, Arunpatcha, Zeller, Matthias, Bruckner, Christian

“…Indaphyrins, pyrrole-modified porphyrins containing a cleaved pyrrole [beta],[beta]'-bond and two annulated indanone moieties, possess unusually broadened and…”
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Synthesis of BI 894416 and BI 1342561, two potent and selective spleen tyrosine kinase inhibitors, labeled with carbon 14 and with deuterium by Latli, Bachir, Hrapchak, Matt J., Samankumara, Lalith P., Fandrick, Daniel R., Pennino, Scott, Lee, Heewon, Song, Jinhua J.

“…(R)‐4‐((R)‐1‐((6‐(1‐[tert‐butyl]‐1H‐pyrazol‐4‐yl)‐2‐methyl‐2H‐pyrazolo[3,4‐d]pyridin‐4‐yl)oxy)ethyl)pyrrolidin‐2‐one (BI 894416, 1) and…”
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A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins by Qu, Bo, Samankumara, Lalith P., Ma, Shengli, Fandrick, Keith R., Desrosiers, Jean-Nicolas, Rodriguez, Sonia, Li, Zhibin, Haddad, Nizar, Han, Zhengxu S., McKellop, Keith, Pennino, Scott, Grinberg, Nelu, Gonnella, Nina C., Song, Jinhua J., Senanayake, Chris H.

“…Air‐stable P‐chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium‐catalyzed asymmetric…”
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Syntheses, structures, modification, and optical properties of meso-tetraaryl-2,3-dimethoxychlorin, and two isomeric meso-tetraaryl-2,3,12,13-tetrahydroxybacteriochlorins by Samankumara, Lalith P, Zeller, Matthias, Krause, Jeanette A, Brückner, Christian

“…The refined syntheses, modification, and first X-ray structural characterization of meso-tetraarylporphyrin-derived beta-tetraolbacteriochlorins are described…”
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Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer by LaPorte, Matthew G., Alverez, Celeste, Chatterley, Alexander, Kovaliov, Marina, Carder, Evan J., Houghton, Michael J., Lim, Chaemin, Miller, Eric R., Samankumara, Lalith P., Liang, Mary, Kerrigan, Kaylan, Yue, Zhizhou, Li, Shan, Tomaino, Francesca, Wang, Feng, Green, Neal, Stott, Gordon M., Srivastava, Apurva, Chou, Tsui-Fen, Wipf, Peter, Huryn, Donna M.

“…The AAA+ ATPase p97 (valosin-containing protein, VCP) is a master regulator of protein homeostasis and therefore represents a novel target for cancer therapy…”
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Development of New P‑Chiral P,π-Dihydrobenzooxaphosphole Hybrid Ligands for Asymmetric Catalysis by Sieber, Joshua D, Chennamadhavuni, Divya, Fandrick, Keith R, Qu, Bo, Han, Zhengxu S, Savoie, Jolaine, Ma, Shengli, Samankumara, Lalith P, Grinberg, Nelu, Lee, Heewon, Song, Jinhua J, Senanayake, Chris H

“…A new family of P-chiral P,π-hybrid ligands was prepared from the dihydrobenzooxaphosphole core. These new ligands were demonstrated to be both sterically and…”
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Synthesis of Pyridyl-dihydrobenzooxaphosphole Ligands and Their Application in Asymmetric Hydrogenation of Unfunctionalized Alkenes by Qu, Bo, Samankumara, Lalith P, Savoie, Jolaine, Fandrick, Daniel R, Haddad, Nizar, Wei, Xudong, Ma, Shengli, Lee, Heewon, Rodriguez, Sonia, Busacca, Carl A, Yee, Nathan K, Song, Jinhua J, Senanayake, Chris H

“…Synthesis of the electron-rich 2-substituted-6-(phenyl­sulfonyl)­pyridines is presented. A series of air-stable, tunable, P-chiral…”
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Expanded Bacteriochlorins by Samankumara, Lalith P., Wells, Sarah, Zeller, Matthias, Acuña, Alonso M., Röder, Beate, Brückner, Christian

“…Ruffled rings: Both pyrrolidine moieties in meso‐tetraaryl‐7,8,17,18‐tetrahydroxybacteriochlorins can be sequentially expanded into morpholine rings to give…”
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The breaking and mending of porphyrins: reductive coupling of secochlorin bisaldehydes by Akhigbe, Joshua, Samankumara, Lalith P., Brückner, Christian

“…Reaction of known secochlorin bisaldehyde–made from meso-tetraphenylporphyrin (TPP) by two-step oxidation–with hydrazine induces a reductive coupling reaction…”
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A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site by Burnett, James C, Lim, Chaemin, Peyser, Brian D, Samankumara, Lalith P, Kovaliov, Marina, Colombo, Raffaele, Bulfer, Stacie L, LaPorte, Matthew G, Hermone, Ann R, McGrath, Connor F, Arkin, Michelle R, Gussio, Rick, Huryn, Donna M, Wipf, Peter

“…The turnstile motion of two neighboring threonines sets up a dynamic side chain interplay that can accommodate both polar and apolar ligands in a small…”
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A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins by Qu, Bo, Samankumara, Lalith P., Ma, Shengli, Fandrick, Keith R., Desrosiers, Jean-Nicolas, Rodriguez, Sonia, Li, Zhibin, Haddad, Nizar, Han, Zhengxu S., McKellop, Keith, Pennino, Scott, Grinberg, Nelu, Gonnella, Nina C., Song, Jinhua J., Senanayake, Chris H.

“…Air‐stable P‐chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium‐catalyzed asymmetric…”
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Efficient Asymmetric Synthesis of Structurally Diverse P-Stereogenic Phosphinamides for Catalyst Design by Han, Zhengxu S., Zhang, Li, Xu, Yibo, Sieber, Joshua D., Marsini, Maurice A., Li, Zhibin, Reeves, Jonathan T., Fandrick, Keith R., Patel, Nitinchandra D., Desrosiers, Jean-Nicolas, Qu, Bo, Chen, Anji, Rudzinski, DiAndra M., Samankumara, Lalith P., Ma, Shengli, Grinberg, Nelu, Roschangar, Frank, Yee, Nathan K., Wang, Guijun, Song, Jinhua J., Senanayake, Chris H.

“…The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a…”
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