Search Results - "Samani, Nilesh J."

High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis by Tomaszewski, Maciej, White, Christobelle, Patel, Prashanth, Masca, Nicholas, Damani, Ravi, Hepworth, Joanne, Samani, Nilesh J, Gupta, Pankaj, Madira, Webster, Stanley, Adrian, Williams, Bryan

“…Non-adherence to therapy is an important cause of suboptimal blood pressure control but few practical tools exist to accurately and routinely detect it. We…”
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Genomic prediction of coronary heart disease by Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

“…Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such…”
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Mendelian randomization of blood lipids for coronary heart disease by Holmes, Michael V, Asselbergs, Folkert W, Palmer, Tom M, Drenos, Fotios, Lanktree, Matthew B, Nelson, Christopher P, Dale, Caroline E, Padmanabhan, Sandosh, Finan, Chris, Swerdlow, Daniel I, Tragante, Vinicius, van Iperen, Erik P A, Sivapalaratnam, Suthesh, Shah, Sonia, Elbers, Clara C, Shah, Tina, Engmann, Jorgen, Giambartolomei, Claudia, White, Jon, Zabaneh, Delilah, Sofat, Reecha, McLachlan, Stela, Doevendans, Pieter A, Balmforth, Anthony J, Hall, Alistair S, North, Kari E, Almoguera, Berta, Hoogeveen, Ron C, Cushman, Mary, Fornage, Myriam, Patel, Sanjay R, Redline, Susan, Siscovick, David S, Tsai, Michael Y, Karczewski, Konrad J, Hofker, Marten H, Verschuren, W Monique, Bots, Michiel L, van der Schouw, Yvonne T, Melander, Olle, Dominiczak, Anna F, Morris, Richard, Ben-Shlomo, Yoav, Price, Jackie, Kumari, Meena, Baumert, Jens, Peters, Annette, Thorand, Barbara, Koenig, Wolfgang, Gaunt, Tom R, Humphries, Steve E, Clarke, Robert, Watkins, Hugh, Farrall, Martin, Wilson, James G, Rich, Stephen S, de Bakker, Paul I W, Lange, Leslie A, Davey Smith, George, Reiner, Alex P, Talmud, Philippa J, Kivimäki, Mika, Lawlor, Debbie A, Dudbridge, Frank, Samani, Nilesh J, Keating, Brendan J, Hingorani, Aroon D, Casas, Juan P

“…To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental…”
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DNA methylation and body-mass index: a genome-wide analysis by Dick, Katherine J, PhD, Nelson, Christopher P, PhD, Tsaprouni, Loukia, PhD, Sandling, Johanna K, PhD, Aïssi, Dylan, MSc, Wahl, Simone, MSc, Meduri, Eshwar, PhD, Morange, Pierre-Emmanuel, Prof, Gagnon, France, PhD, Grallert, Harald, PhD, Waldenberger, Melanie, PhD, Peters, Annette, Prof, Erdmann, Jeanette, Prof, Hengstenberg, Christian, Prof, Cambien, Francois, Prof, Goodall, Alison H, Prof, Ouwehand, Willem H, Prof, Schunkert, Heribert, Prof, Thompson, John R, Prof, Spector, Tim D, FRCP, Gieger, Christian, PhD, Trégouët, David-Alexandre, PhD, Deloukas, Panos, Prof, Samani, Nilesh J, Prof

“…Summary Background Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although…”
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The clinical significance of interleukin‐6 in heart failure: results from the BIOSTAT‐CHF study by Markousis‐Mavrogenis, George, Tromp, Jasper, Ouwerkerk, Wouter, Devalaraja, Matt, Anker, Stefan D., Cleland, John G., Dickstein, Kenneth, Filippatos, Gerasimos S., Harst, Pim, Lang, Chim C., Metra, Marco, Ng, Leong L., Ponikowski, Piotr, Samani, Nilesh J, Zannad, Faiez, Zwinderman, Aeilko H., Hillege, Hans L., Veldhuisen, Dirk J., Kakkar, Rahul, Voors, Adriaan A., Meer, Peter

“…Aims Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)‐α were largely…”
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ANGPTL3 Deficiency and Protection Against Coronary Artery Disease by Stitziel, Nathan O., MD, PhD, Khera, Amit V., MD, Wang, Xiao, PhD, Bierhals, Andrew J., MD, MPH, Vourakis, A. Christina, BA, Sperry, Alexandra E., BA, Natarajan, Pradeep, MD, Klarin, Derek, MD, Emdin, Connor A., DPhil, Zekavat, Seyedeh M., BSc, Nomura, Akihiro, MD, Erdmann, Jeanette, PhD, Schunkert, Heribert, MD, Samani, Nilesh J., MD, Kraus, William E., MD, Shah, Svati H., MD, MPH, Yu, Bing, PhD, Boerwinkle, Eric, PhD, Rader, Daniel J., MD, Gupta, Namrata, PhD, Frossard, Philippe M., PhD, Rasheed, Asif, MBBS, Danesh, John, DPhil, Lander, Eric S., PhD, Gabriel, Stacey, PhD, Saleheen, Danish, MBBS, PhD, Musunuru, Kiran, MD, PhD, MPH, Kathiresan, Sekar, MD

“…Abstract Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by…”
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Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses by Sun, Luanluan, Pennells, Lisa, Kaptoge, Stephen, Nelson, Christopher P, Ritchie, Scott C, Abraham, Gad, Arnold, Matthew, Bell, Steven, Bolton, Thomas, Burgess, Stephen, Dudbridge, Frank, Guo, Qi, Sofianopoulou, Eleni, Stevens, David, Thompson, John R, Butterworth, Adam S, Wood, Angela, Danesh, John, Samani, Nilesh J, Inouye, Michael, Di Angelantonio, Emanuele

“…Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding…”
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Human metabolic individuality in biomedical and pharmaceutical research by Suhre, Karsten, Shin, So-Youn, Petersen, Ann-Kristin, Mohney, Robert P., Meredith, David, Wägele, Brigitte, Altmaier, Elisabeth, Deloukas, Panos, Erdmann, Jeanette, Grundberg, Elin, Hammond, Christopher J., de Angelis, Martin Hrabé, Kastenmüller, Gabi, Köttgen, Anna, Kronenberg, Florian, Mangino, Massimo, Meisinger, Christa, Meitinger, Thomas, Mewes, Hans-Werner, Milburn, Michael V., Prehn, Cornelia, Raffler, Johannes, Ried, Janina S., Römisch-Margl, Werner, Samani, Nilesh J., Small, Kerrin S., -Erich Wichmann, H., Zhai, Guangju, Illig, Thomas, Spector, Tim D., Adamski, Jerzy, Soranzo, Nicole, Gieger, Christian

“…Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the…”
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Risk Factors for Nonadherence to Antihypertensive Treatment by Gupta, Pankaj, Patel, Prashanth, Štrauch, Branislav, Lai, Florence Y, Akbarov, Artur, Marešová, Věra, White, Christobelle M J, Petrák, Ondřej, Gulsin, Gaurav S, Patel, Veena, Rosa, Ján, Cole, Richard, Zelinka, Tomáš, Holaj, Robert, Kinnell, Angela, Smith, Paul R, Thompson, John R, Squire, Iain, Widimský, Jr, Jiří, Samani, Nilesh J, Williams, Bryan, Tomaszewski, Maciej

“…Nonadherence to antihypertensive treatment is a critical contributor to suboptimal blood pressure control. There are limited and heterogeneous data on the risk…”
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Selenium and outcome in heart failure by Bomer, Nils, Grote Beverborg, Niels, Hoes, Martijn F., Streng, Koen W., Vermeer, Mathilde, Dokter, Martin M., IJmker, Jan, Anker, Stefan D., Cleland, John G.F., Hillege, Hans L., Lang, Chim C., Ng, Leong L., Samani, Nilesh J., Tromp, Jasper, Veldhuisen, Dirk J., Touw, Daan J., Voors, Adriaan A., Meer, Peter

“…Aims Severe deficiency of the essential trace element selenium can cause myocardial dysfunction although the mechanism at cellular level is uncertain. Whether,…”
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Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels by Emdin, Connor A., DPhil, Khera, Amit V., MD, Natarajan, Pradeep, MD, Klarin, Derek, MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Stitziel, Nathan O., MD, PhD, Nomura, Akihiro, MD, Zekavat, Seyedeh M., BSc, Bick, Alexander G., MD, Gupta, Namrata, PhD, Asselta, Rosanna, PhD, Duga, Stefano, PhD, Merlini, Piera Angelica, MD, Correa, Adolfo, MD, Kessler, Thorsten, MD, Wilson, James G., MD, Bown, Matthew J., MD, Hall, Alistair S., MD, Braund, Peter S., PhD, Samani, Nilesh J., MD, Schunkert, Heribert, MD, Marrugat, Jaume, MD, PhD, Elosua, Roberto, MD, PhD, McPherson, Ruth, MD, Farrall, Martin, PhD, Watkins, Hugh, MD, PhD, Willer, Cristen, PhD, Abecasis, Gonçalo R., PhD, Felix, Janine F., MD, PhD, Vasan, Ramachandran S., MD, Lander, Eric, PhD, Rader, Daniel J., MD, Danesh, John, MSc, DPhil, Ardissino, Diego, MD, Gabriel, Stacey, PhD, Saleheen, Danish, MD, Kathiresan, Sekar, MD

“…Abstract Background Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk…”
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Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis by Lai, Florence Y, Nath, Mintu, Hamby, Stephen E, Thompson, John R, Nelson, Christopher P, Samani, Nilesh J

“…Adult height is associated with risk of several diseases, but the breadth of such associations and whether these associations are primary or due to confounding…”
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Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study by Brouilette, Scott W, PhD, Moore, Jasbir S, MSc, McMahon, Alex D, PhD, Thompson, John R, Prof, Ford, Ian, Prof, Shepherd, James, Prof, Packard, Chris J, Prof, Samani, Nilesh J, Prof

“…Summary Background Inter-individual differences in biological ageing could affect susceptibility to coronary heart disease. Our aim was to determine whether…”
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The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits by Voight, Benjamin F, Kang, Hyun Min, Ding, Jun, Palmer, Cameron D, Sidore, Carlo, Chines, Peter S, Burtt, Noël P, Fuchsberger, Christian, Li, Yanming, Erdmann, Jeanette, Frayling, Timothy M, Heid, Iris M, Jackson, Anne U, Johnson, Toby, Kilpeläinen, Tuomas O, Lindgren, Cecilia M, Morris, Andrew P, Prokopenko, Inga, Randall, Joshua C, Saxena, Richa, Soranzo, Nicole, Speliotes, Elizabeth K, Teslovich, Tanya M, Wheeler, Eleanor, Maguire, Jared, Parkin, Melissa, Potter, Simon, Rayner, N William, Robertson, Neil, Stirrups, Kathleen, Winckler, Wendy, Sanna, Serena, Mulas, Antonella, Nagaraja, Ramaiah, Cucca, Francesco, Barroso, Inês, Deloukas, Panos, Loos, Ruth J F, Kathiresan, Sekar, Munroe, Patricia B, Newton-Cheh, Christopher, Pfeufer, Arne, Samani, Nilesh J, Schunkert, Heribert, Hirschhorn, Joel N, Altshuler, David, McCarthy, Mark I, Abecasis, Gonçalo R, Boehnke, Michael

“…Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related…”
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Waist‐to‐hip ratio and mortality in heart failure by Streng, Koen W., Voors, Adriaan A., Hillege, Hans L., Anker, Stefan D., Cleland, John G., Dickstein, Kenneth, Filippatos, Gerasimos, Metra, Marco, Ng, Leong L., Ponikowski, Piotr, Samani, Nilesh J., van Veldhuisen, Dirk J., Zwinderman, Aeilko H., Zannad, Faiez, Damman, Kevin, van der Meer, Peter, Lang, Chim C.

“…Aims A higher body mass index (BMI) is associated with better survival in heart failure (HF) patients, also known as the obesity paradox. However, BMI does not…”
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Reproducibility of telomere length assessment: an international collaborative study by Martin-Ruiz, Carmen M, Baird, Duncan, Roger, Laureline, Boukamp, Petra, Krunic, Damir, Cawthon, Richard, Dokter, Martin M, van der Harst, Pim, Bekaert, Sofie, de Meyer, Tim, Roos, Goran, Svenson, Ulrika, Codd, Veryan, Samani, Nilesh J, McGlynn, Liane, Shiels, Paul G, Pooley, Karen A, Dunning, Alison M, Cooper, Rachel, Wong, Andrew, Kingston, Andrew, von Zglinicki, Thomas

“…Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and…”
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Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease by Mäkinen, Ville-Petteri, Civelek, Mete, Meng, Qingying, Zhang, Bin, Zhu, Jun, Levian, Candace, Huan, Tianxiao, Segrè, Ayellet V, Ghosh, Sujoy, Vivar, Juan, Nikpay, Majid, Stewart, Alexandre F R, Nelson, Christopher P, Willenborg, Christina, Erdmann, Jeanette, Blakenberg, Stefan, O'Donnell, Christopher J, März, Winfried, Laaksonen, Reijo, Epstein, Stephen E, Kathiresan, Sekar, Shah, Svati H, Hazen, Stanley L, Reilly, Muredach P, Lusis, Aldons J, Samani, Nilesh J, Schunkert, Heribert, Quertermous, Thomas, McPherson, Ruth, Yang, Xia, Assimes, Themistocles L

“…The majority of the heritability of coronary artery disease (CAD) remains unexplained, despite recent successes of genome-wide association studies (GWAS) in…”
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Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease by SCHUNKERT, Heribert, GÖTZ, Anika, BLANKENBERG, Stefan, TIRET, Laurence, DUCIMETIERE, Pierre, KENIRY, Andrew, GHORI, Mohammed J. R, SCHREIBER, Stefan, EL MOKHTARI, Nour Eddine, HALL, Alistair S, DIXON, Richard J, GOODALL, Alison H, BRAUND, Peter, LIPTAU, Henrike, POLLARD, Helen, SCHWARZ, Daniel F, HOTHOM, Ludwig A, WICHMANN, H.-Erich, KÖNIG, Inke R, FISCHER, Marcus, MEISINGER, Christa, OUWEHAND, Willem, DELOUKAS, Panos, MCGINNIS, Ralph, THOMPSON, John R, ERDMANN, Jeanette, ZIEGLER, Andreas, SAMANI, Nilesh J, TREGOUET, David-Alexandre, MANGINO, Massimo, LINSEL-NITSCHKE, Patrick, CAMBIEN, Francois, HENGSTENBERG, Christian, STARK, Klaus

“…Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the…”
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Genomewide Association Analysis of Coronary Artery Disease by Samani, Nilesh J, Erdmann, Jeanette, Hall, Alistair S, Hengstenberg, Christian, Mangino, Massimo, Mayer, Bjoern, Dixon, Richard J, Meitinger, Thomas, Braund, Peter, Wichmann, H.-Erich, Barrett, Jennifer H, König, Inke R, Stevens, Suzanne E, Szymczak, Silke, Tregouet, David-Alexandre, Iles, Mark M, Pahlke, Friedrich, Pollard, Helen, Lieb, Wolfgang, Cambien, Francois, Fischer, Marcus, Ouwehand, Willem, Blankenberg, Stefan, Balmforth, Anthony J, Baessler, Andrea, Ball, Stephen G, Strom, Tim M, Brænne, Ingrid, Gieger, Christian, Deloukas, Panos, Tobin, Martin D, Ziegler, Andreas, Thompson, John R, Schunkert, Heribert

“…Using the technique of genomewide association analysis, the authors found a locus on chromosome 9 (9p21.3) that is strongly associated with familial coronary…”
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Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease by Waterworth, Dawn M, Ricketts, Sally L, Song, Kijoung, Chen, Li, Zhao, Jing Hua, Ripatti, Samuli, Aulchenko, Yurii S, Zhang, Weihua, Yuan, Xin, Lim, Noha, Luan, Jianʼan, Ashford, Sofie, Wheeler, Eleanor, Young, Elizabeth H, Hadley, David, Thompson, John R, Braund, Peter S, Johnson, Toby, Struchalin, Maksim, Surakka, Ida, Luben, Robert, Khaw, Kay-Tee, Rodwell, Sheila A, Loos, Ruth J.F, Boekholdt, S. Matthijs, Inouye, Michael, Deloukas, Panagiotis, Elliott, Paul, Schlessinger, David, Sanna, Serena, Scuteri, Angelo, Jackson, Anne, Mohlke, Karen L, Tuomilehto, Jaako, Roberts, Robert, Stewart, Alexandre, Kesäniemi, Y. Antero, Mahley, Robert W, Grundy, Scott M, McArdle, Wendy, Cardon, Lon, Waeber, Gérard, Vollenweider, Peter, Chambers, John C, Boehnke, Michael, Abecasis, Gonçalo R, Salomaa, Veikko, Järvelin, Marjo-Riitta, Ruokonen, Aimo, Barroso, Inês, Epstein, Stephen E, Hakonarson, Hakon H, Rader, Daniel J, Reilly, Muredach P, Witteman, Jacqueline C.M, Hall, Alistair S, Samani, Nilesh J, Strachan, David P, Barter, Philip, van Duijn, Cornelia M, Kooner, Jaspal S, Peltonen, Leena, Wareham, Nicholas J, McPherson, Ruth, Mooser, Vincent, Sandhu, Manjinder S

“…OBJECTIVE—Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a…”
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