Effects of Bemiparin, Dalteparin, and Unfractionated Heparin on Platelet Interaction With Human Subendothelium Under Flow Conditions

Effects of Bemiparin, Dalteparin, and Unfractionated Heparin on Platelet Interaction With Human Subendothelium Under Flow Conditions

We compared the effects of the low-molecular-weight heparin (LMWH), bemiparin, and dalteparin with unfractionated heparin (UFH) on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, although the e...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences Vol. 107; no. 1; pp. 103 - 106
Main Authors: González-Correa, Jose Antonio, Arrebola, María Monsalud, Mérida, Francisco, Navas, María Dolores, López-Villodres, Juan Antonio, Samanes, Felisa, De La Cruz, José Pedro
Format: Journal Article
Language:English
Published: Japan Elsevier B.V 2008
The Japanese Pharmacological Society
Elsevier
Subjects:
Adult
Anticoagulants - pharmacology
bemiparin
Blood Platelets - drug effects
Cell Adhesion - drug effects
Cells, Cultured
Dalteparin - pharmacology
Endothelial Cells - drug effects
Heparin - pharmacology
Heparin, Low-Molecular-Weight - pharmacology
Humans
Male
platelet
Platelet Adhesiveness - drug effects
Pulsatile Flow
Stress, Mechanical
subendothelium
platelet
bemiparin
subendothelium
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Summary:We compared the effects of the low-molecular-weight heparin (LMWH), bemiparin, and dalteparin with unfractionated heparin (UFH) on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, although the effect of LMWH was greater than that of UFH. Subendothelial matrix covered with platelet structures greater than 100 square microns was significantly reduced by all three compounds; the effect of bemiparin tended to be greater than that of the other two heparins.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.08018SC