Search Results - "Samanen, James"

Mode of Action for Linear Peptide Inhibitors of HIV-1 gp120 Interactions by Biorn, Alyssa C, Cocklin, Simon, Madani, Navid, Si, Zhihai, Ivanovic, Tijana, Samanen, James, Van Ryk, Donald I, Pantophlet, Ralph, Burton, Dennis R, Freire, Ernesto, Sodroski, Joseph, Chaiken, Irwin M

“…The linear peptide 12p1 (RINNIPWSEAMM) was previously isolated from a phage display library and was found to inhibit interaction of HIV-1 gp120 with both CD4…”
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Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists by Miller, William H, Manley, Peter J, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Kwon, Chet, Ross, Stephen T, Samanen, James M, Takata, Dennis T, Uzinskas, Irene N, Yuan, Catherine C.K, Haltiwanger, R.Curtis, Gress, Catherine J, Lark, Michael W, Hwang, Shing-Mei, James, Ian E, Rieman, David J, Willette, Robert N, Yue, Tian-Li, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F

“…In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified…”
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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic by Miller, William H, Alberts, Doreen P, Bhatnagar, Pradip K, Bondinell, William E, Callahan, James F, Calvo, Raul R, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Keenan, Richard M, Kwon, Chet, Manley, Peter J, Newlander, Kenneth A, Ross, Stephen T, Samanen, James M, Uzinskas, Irene N, Venslavsky, Joseph W, Yuan, Catherine C.-K, Haltiwanger, R. Curtis, Gowen, Maxine, Hwang, Shing-Mei, James, Ian E, Lark, Michael W, Rieman, David J, Stroup, George B, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F

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Modulation of vitronectin receptor‐mediated osteoclast adhesion by Arg‐Gly‐Asp peptide analogs: A structure‐function analysis by Horton, Michael A., Dorey, Elaine L., Nesbitt, Stephen A., Samanen, James, Ali, Fadia E., Stadel, Jeffrey M., Nichols, Andrew, Greig, Russel, Helfrich, Miep H.

“…This study details the investigation of induction of retractile shape change in the osteoclast through inhibition of adhesion between osteoclasts and matrix…”
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Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids by Keenan, Richard M, Weinstock, Joseph, Finkelstein, Joseph A, Franz, Robert G, Gaitanopoulos, Dimitri E, Girard, Gerald R, Hill, David T, Morgan, Tina M, Samanen, James M

“…The further evolution of the imidazole-5-acrylic acid series of nonpeptide angiotensin II receptor antagonists is detailed (for Part 1, see: J. Med. Chem…”
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Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists by Samanen, James M, Ali, Fadia E, Barton, Linda S, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Wenting, Chen, Lichong, Erhard, Karl, Feuerstein, Giora, Heys, Richard, Hwang, Shing-Mei, Jakas, Dalia R, Keenan, Richard M, Ku, Thomas W, Kwon, Chet, Lee, Chao-Pin, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael, Peishoff, Catherine E, Rhodes, Gerald, Ross, Steven, Shu, Arthur, Simpson, Richard, Takata, Dennis, Yellin, Tobias O, Uzsinskas, Irene, Venslavsky, Joseph W, Yuan, Chuan-Kui, Huffman, William F

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Enantioselective routes to protected syn- and anti-.beta.-phenylcysteines by Lago, M. Amparo, Samanen, James, Elliott, John D

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Chemical Approaches to Improve the Oral Bioavailability of Peptidergic Molecules by SAMANEN, JAMES, WILSON, GLYNN, SMITH, PHILIP L., LEE, CHAO-PIN, BONDINELL, WILLIAM, KU, THOMAS, RHODES, GERALD, NICHOLS, ANDREW

“…This review discusses both tools and strategies that may be employed as approaches towards the pursuit of orally active compounds from peptidergic molecules…”
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Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore by Ku, Thomas W, Miller, William H, Bondinell, William E, Erhard, Karl F, Keenan, Richard M, Nichols, Andrew J, Peishoff, Catherine E, Samanen, James M, Wong, Angela S, Huffman, William F

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Discovery of Potent Nonpeptide Vitronectin Receptor (αVβ3) Antagonists by Keenan, Richard M, Miller, William H, Kwon, Chet, Ali, Fadia E, Callahan, James F, Calvo, Raul R, Hwang, Shing-Mei, Kopple, Kenneth D, Peishoff, Catherine E, Samanen, James M, Wong, Angela S, Yuan, Chuan-Kui, Huffman, William F

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The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists by Samanen, James M., Lee, Chao-Pin, Smith, Philip L., Bondinell, William E., Calvo, Raul R., Jakas, Dalia R., Newlander, Kenneth A., Parker, Michael, Uzinskas, Irene, Yellin, Tobias O., Nichols, Andrew J.

“…A series of potent, high affinity GPIIb/IIIa antagonists were evaluated for intestinal permeability in vitro using rabbit intestinal strips mounted in the…”
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The p-(methylsulfinyl)benzyl group: a trifluoroacetic acid (TFA)-stable carboxyl-protecting group readily convertible to a TFA-labile group by Samanen, James M, Brandeis, Ester

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Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist by Miller, William H., Ku, Thomas W., Ali, Fadia E., Bondinell, William E., Calvo, Raul R., Davis, Larry D., Erhard, Karl F., Hall, Leon B., Huffman, William F., Keenan, Richard M., Kwon, Chet, Newlander, Kenneth A., Ross, Stephen T., Samanen, James M., Takata, Dennis T., Yuan, Chuan-Kui

“…An enantiospecific synthesis of SB 214857, a potent, nonpeplide fibrinogen receptor antagonist, is reported. The synthetic route employs as a key step an…”
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Biogenetic-type approach to homoerythrina alkaloids by Marino, Joseph P, Samanen, James M

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The antithrombotic efficacy of lotrafiban (SB 214857) in canine models of acute coronary thrombosis by Toomey, John R, Samanen, James, Valocik, Richard E, Koster, Paul F, Barone, Frank C, Willette, Robert N

“…In patients with acute coronary syndromes, inhibition of platelet aggregation with parenteral alpha(IIb)/beta(III) antagonists has proven effective at…”
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The in vitro pharmacological profile of SK&F 106760, a novel GPIIB/IIIA antagonist by Nichols, A J, Vasko, J A, Valocik, R E, Kopaciewicz, L J, Storer, B L, Ali, F E, Romoff, T, Calvo, R, Samanen, J M

“…The properties of SK&F 106760 [N alpha-acetyl-cyclo(S,S)-cysteinyl-N alpha-methyl-arginyl-glycyl-aspartyl-penicillamine-amide] as a GPIIb/IIIa antagonist have…”
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Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionalized hexahydroisoindoles by Heerding, Dirk A., Takata, Dennis T., Kwon, Chet, Huffman, William F., Samanen, James

“…We show here the first example of a ruthenium catalyzed ene-yne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to efficiently form…”
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Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists by Keenan, Richard M, Callahan, James F, Samanen, James M, Bondinell, William E, Calvo, Raul R, Chen, Lichong, DeBrosse, Charles, Eggleston, Drake S, Haltiwanger, R. Curtis, Hwang, Shing Mei, Jakas, Dalia R, Ku, Thomas W, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael F, Southhall, Linda S, Uzinskas, Irene, Vasko-Moser, Janice A, Venslavsky, Joseph W, Wong, Angela S, Huffman, William F

“…Previously, we reported the direct design of highly potent nonpeptide 3-oxo-1,4-benzodiazepine fibrinogen receptor antagonists from a constrained,…”
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Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide by Ku, Thomas W, Ali, Fadia E, Barton, Linda S, Bean, John W, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Lichong

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Development of GPIIb/IIIa antagonists as antithrombotic drugs by Nichols, A J, Ruffolo, Jr, R R, Huffman, W F, Poste, G, Samanen, J

“…Thrombosis represents a major target for development of drugs to prevent and treat a variety of cardiovascular and cerebrovascular diseases, which are the…”
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