Search Results - "Samama, Philippe"

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins by Lefkowitz, R J, Cotecchia, S, Samama, P, Costa, T

“…Adrenoceptors are prototypic members of the superfamily of seven transmembrane domain, G protein-coupled receptors. Study of the properties of several…”
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Ligand-induced overexpression of a constitutively active β2-adrenergic receptor: Pharmacological creation of a phenotype in transgenic mice by Samama, Philippe, Bond, Richard A., Rockman, Howard A., Milano, Carmelo A., Lefkowitz, Robert J.

“…Transgenic overexpression (40- to 100-fold) of the wild-type human β 2 -adrenergic receptor in the hearts of mice leads to a marked increase in cardiac…”
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A mutation-induced activated state of the β2-adrenergic receptor : extending the ternary complex model by SAMAMA, P, COTECCHIA, S, COSTA, T, LEFKOWITZ, R. J

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Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor by Koch, Walter J., Rockman, Howard A., Samama, Philippe, Hamilton, RaeAnn, Bond, Richard A., Milano, Carmelo A., Lefkowitz, Robert J.

“…Transgenic mice were created with cardiac-specific overexpression of the β-adrenergic receptor kinase-1 (βARK1) or a βARK inhibitor. Animals overexpressing…”
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The melanocortin receptor MCR4 controls fat consumption by Samama, Philippe, Rumennik, Leonid, Grippo, Joseph F.

“…Melanocortins mediate the effects of leptin in the central nervous system (CNS) and regulate energy balance through the MCR3 and MCR4 receptors. Here, we…”
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A Constitutively Active Mutant β2-Adrenergic Receptor is Constitutively Desensitized and Phosphorylated by Pei, Gang, Samama, Philippe, Lohse, Martin, Wang, Mei, Codina, Juan, Lefkowitz, Robert J.

“…The β2-adrenergic receptor (β2AR) can be constitutively activated by mutations in the third intracellular loop. Whereas the wild-type receptor exists…”
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Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists by Ho, Koc-Kan, Auld, Douglas S., Bohnstedt, Adolph C., Conti, Paolo, Dokter, Wim, Erickson, Shawn, Feng, Daming, Inglese, Jim, Kingsbury, Celia, Kultgen, Steven G., Liu, Rong-Qiang, Masterson, Christopher M., Ohlmeyer, Michael, Rong, Yajing, Rooseboom, Martijn, Roughton, Andrew, Samama, Philippe, Smit, Martin-Jan, Son, Ellen, van der Louw, Jaap, Vogel, Gerard, Webb, Maria, Wijkmans, Jac, You, Ming

“…Imidazolylpyrimidine based CXCR2 chemokine receptor antagonist was optimized for potency, in vitro metabolic stability, and oral bioavailability. Potent and…”
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Chemokine Receptor−Ligand Interactions Measured Using Time-Resolved Fluorescence by Inglese, James, Samama, Philippe, Patel, Sanjay, Burbaum, Jonathan, Stroke, Ilana L, Appell, Kenneth C

“…Two G protein-coupled receptor subtypes (CXCR1 and CXCR2) mediate Interleukin-8 (IL8) action in cells. A nonradioactive lanthanide−chelate derivatized IL8…”
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Combinatorial gene expression using multiple episomal vectors by Horlick, Robert A., Schilling, Adriane E., Samama, Philippe, Swanson, Robert N., Fitzpatrick, V.Danial, Robbins, Alan K., Damaj, Bassam

“…Episomal vectors offer a powerful alternative to integrative recombination for transgene expression in mammalian cells. In this study, various combinations of…”
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Rat brain glutamic acid decarboxylase sequence deduced from a cloned cDNA by Julien, J F, Samama, P, Mallet, J

“…A cDNA clone complementary to the rat brain glutamic acid decarboxylase mRNA was isolated from a rat brain cDNA expression library using an antibody specific…”
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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a betaARK inhibitor by Koch, Walter J, Rockman, Howard A, Samama, Philippe, Hamilton, RaeAnn

“…Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (betaARK1) or a betaARK inhibitor. Because increased…”
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Development of a fluorescent ligand-binding assay using the AcroWell filter plate by Valenzano, K J, Miller, W, Kravitz, J N, Samama, P, Fitzpatrick, D, Seeley, K

“…One of the most powerful tools for receptor research and drug discovery is the use of receptor-ligand affinity screening of combinatorial libraries. Early work…”
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A constitutively active mutant (beta2)-adrenergic receptor is constitutively desensitized and phosphorylated by Samama, Philippe, Lohse, Martin, Codina, Juan, Lefkowitz, Robert J

“…It was shown that not only is the mutant beta2-adrenergic receptor constitutively active, it is also constitutively desensitized and down-regulated. In an…”
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Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice by Samama, P, Bond, R A, Rockman, H A, Milano, C A, Lefkowitz, R J

“…Transgenic overexpression (40- to 100-fold) of the wild-type human beta2-adrenergic receptor in the hearts of mice leads to a marked increase in cardiac…”
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Ligand-Induced Overexpression of a Constitutively Active β 2-adrenergic Receptor: Pharmacological Creation of a Phenotype in Transgenic Mice by Samama, Philippe, Bond, Richard A., Rockman, Howard A., Milano, Carmelo A., Lefkowitz, Robert J.

“…Transgenic overexpression (40- to 100-fold) of the wild-type human β 2-adrenergic receptor in the hearts of mice leads to a marked increase in cardiac…”
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Cardiac function in mice overexpressing the Beta-adrenergic receptor kinase or a BataARK inhibitor. (Beta-adrenergic receptor kinase) by Koch, Walter J, Rockman, Howard A, Samama, Philippe, Hamilton, RaeAnn, Bond, Richard A, Milano, Carmelo A, Lefkowitz, Robert J

“…Transgenic mice were created with cardiac-specific overexpression of the [beta]-adrenergic receptor kinase-1 ([beta]ARK1) or a PARK inhibitor. Animals…”
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Bioamine receptors: evolutionary and functional variations of a structural leitmotiv by Vernier, P, Philippe, H, Samama, P, Mallet, J

“…Bioamines act as neurohormonal messengers through their binding to receptors which belong to the largest membrane protein family known so far: the seven…”
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